Review of Clenbuterol – Buy Clenbuterol Liquid 200mcg per ml (30ml)Admin
Clenbuterol is a long-acting adrenergic beta-2 receptor agonist associated with increased skeletal muscle growth in certain mammals.
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Clenbuterol belongs to a class of beta-2 agonists. It is also known as Spiropent, Dilaterol, and Ventipulmin.
Clenbuterol also behaves like salbutamol and epinephrine, but it provides a more pronounced and long-lasting effect.
STRUCTURE OF CLENBUTEROL
Molecular formula: C12H18Cl2N2O
Molecular weight: 277.19g/mol
CAS number: 37148-27-9
IUPAC name: 1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol
MECHANISM OF ACTION
Clenbuterol is a substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low concentrations. It is similar in some structural respects to salbutamol. Agonism of the beta(2) receptor stimulates adenylyl cyclase activity, which leads to smooth muscle relaxation in the bronchioles.
Research shows that clenbuterol has a half-life of 26 hours and is detected in the blood after 48 hours of administration to test subjects. It is excreted in the urine.
Clenbuterol animal research has shown that it works by increasing the production of noradrenaline and epinephrine, leading to the effects listed below:
- It causes bronchodilation and decongestion in the upper respiratory tract of animal test subjects.
- It causes increased energy.
- Increased lipolysis (fat oxidation).
- It is effective in inducing weight loss by increasing body metabolism.
- It also helps in enhancing body strength and retaining muscle mass.
CLENBUTEROL SIDE EFFECTS
Various animal-based findings have revealed that clenbuterol in high doses can lead to
- Increased heart rate
- Rapid breathing
- Chest pain
- Heart palpitations
- Electrolyte imbalance
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- Hinkle RT, Hodge KMB, Cody DB, Sheldon RJ, Kobilka BK, Isfort RJ. Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the β2-adrenergic receptor. Muscle Nerve. 2002;25(5):729-734. https://doi.org/10.1002/mus.10092
- MacLennan PA, Edwards RH. Effects of clenbuterol and propranolol on muscle mass. Evidence that clenbuterol stimulates muscle β-adrenoceptors to induce hypertrophy. Biochem J. 1989;264(2):573-579. https://doi.org/10.1042/bj2640573
- Petrou M, Wynne DG, Boheler KR, Yacoub MH. Clenbuterol induces hypertrophy of the latissimus dorsi muscle and heart in the rat with molecular and phenotypic changes. Circulation. 1995;92(9):483-489. https://doi.org/10.1161/01.CIR.92.9.483
- Thevis M, Geyer L, Geyer H, et al. Adverse analytical findings with clenbuterol among U-17 soccer players attributed to food contamination issues. Drug Test Anal. 2013;5(5):372-376. https://doi.org/10.1002/dta.1471