MK-677, known as Ibutamoren or Nutrobal, is a non-peptide growth hormone secretagogue. It is often classified as a selective agonist of the ghrelin receptor, a hormone receptor involved in regulating appetite, growth hormone secretion, and energy metabolism.
At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy MK-677 for sale only for research purposes and not for human consumption. It is available in liquid form at 25 mg per ml.
MK-677 is a non-peptide spiro piperidine previously shown to be functionally and mechanically indistinguishable in vitro and in vivo from the potent peptide GHS GHRP-6. MK-677 elevates GH levels, as well as IGF-I and cortisol levels, in dogs after oral administration.
MK-677 is used primarily as a potential treatment for conditions characterized by muscle wasting and impaired growth hormone levels, such as age-related muscle loss or certain hormone deficiencies.
STRUCTURE OF MK-677 (IBUTAMOREN)
Molecular Formula: C27H36N4O5S
Molecular weight: 528.7 g/mol
CAS number: 159634-47-6
IUPAC name: 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
MECHANISM OF ACTION
MK-677 (Ibutamoren) stimulates the release of growth hormone and insulin-like growth factor 1 (IGF-1) in the body. These hormones promote muscle growth, enhance recovery, and regulate several metabolic processes.
MK-677 (Ibutamoren) is active after oral administration in animals with a half-life of more than twenty (20) hours (almost 24 hours).
MK-677 (IBUTAMOREN) EFFECTS
Based on available research, the benefits of MK-677 (Ibutamoren) include:
- Increases growth hormone levels
- Strengthening muscle mass, preventing muscle loss
- Fat burning
- It strengthens bones and enhances bone density
- Reverses nitrogen waste
- It enhances sleep
MK-677 (IBUTAMOREN) SIDE EFFECTS
Below are what researchers noticed during clinical trials with MK-677 (Ibutamoren) use in animal test studies.
- water retention and swelling
- reduced insulin sensitivity and increased hunger
- joint and muscle pain
- headaches and migraines
- increased anxiety
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Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy MK-677 (Ibutamoren) for sale.
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- Murphy MG, Plunkett LM, Gertz BJ, He W, Wittreich J, Polvino WM, Clemmons DR. MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. J Clin Endocrinol Metab. 1998 Feb;83(2):320-5. doi: 10.1210/jcem.83.2.4551. PMID: 9467534.
- The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture J. Am. Geriatr. Soc. (2004)
- Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretagogue (MK-677) in healthy elderly subjects J. Clin. Endocrinol. Metab.(1996)
- Lee J, Kwon A, Chae HW, Lee WJ, Kim TH, Kim HS. Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats. Yonsei Med J. 2018 Dec;59(10):1174-1180. doi: 10.3349/ymj.2018.59.10.1174. PMID: 30450851; PMCID: PMC6240568.