WHAT IS CLENBUTEROL? RESEARCH INFORMATION
Clenbuterol is a long-acting adrenergic beta-2 receptor agonist developed as a bronchodilator chemical, observed during research with animal models. Later in the 1980s, scientists discovered that the research chemical could decrease body fat and increase muscle mass in certain mammals.
STRUCTURE OF CLENBUTEROL
MECHANISM OF ACTION
Clenbuterol belongs to the beta-II adrenergic receptor agonists, which cause decreased airway obstruction and smooth bronchial muscle relaxation. This activation of the receptors (beta-2 adrenergic receptors) on adipose tissues and skeletal muscles is responsible for the lipolytic and anabolic properties of the clenbuterol drug.
Liquid Clenbuterol stimulates the central nervous system and heart in animal test subjects.
Based on research on test subjects, clenbuterol’s excretion out of the body is via urine. It has a half-life of 26 hours and is detected in the blood after 48 hours.
In animal studies, clenbuterol demonstrated the potential to prevent muscle atrophy and increase muscle growth. It also showed increased metabolism by utilizing fat as the only energy source and reducing its storage in the body.
CLENBUTEROL AND BRONCHODILATION
Clenbuterol is a potent beta-agonist that can act as a strong bronchodilator. These research chemicals benefit scientific studies involving animals with lung disorders such as asthma, COPD (chronic obstructive pulmonary disease), lung infections, and emphysema.
Clenbuterol increases the diameter of the narrowed passages and airways to accomplish smooth muscle relaxation.
Clenbuterol can cause these long and short-term side effects:
Short-term side effects:
- Increased blood pressure
- Increased heart rate
- Nervousness and jitters
- Sweating and shaking
- Difficulty sleeping
- Dry mouth and thirstiness
- Cramping and diarrhea
Long-term side effects:
- Increased risk of heart disease and stroke
- Kidney damage
- Liver damage
- Muscle weakness
- Anxiety and depression
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- Hinkle RT, Hodge KMB, Cody DB, Sheldon RJ, Kobilka BK, Isfort RJ. Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the β2-adrenergic receptor. Muscle Nerve. 2002;25(5):729-734. https://doi.org/10.1002/mus.10092
- MacLennan PA, Edwards RH. Effects of clenbuterol and propranolol on muscle mass. Evidence that clenbuterol stimulates muscle β-adrenoceptors to induce hypertrophy. Biochem J. 1989;264(2):573-579. https://doi.org/10.1042/bj2640573
- Petrou M, Wynne DG, Boheler KR, Yacoub MH. Clenbuterol induces hypertrophy of the latissimus dorsi muscle and heart in the rat with molecular and phenotypic changes. Circulation. 1995;92(9):483-489. https://doi.org/10.1161/01.CIR.92.9.483
- Thevis M, Geyer L, Geyer H, et al. Adverse analytical findings with clenbuterol among U-17 soccer players attributed to food contamination issues. Drug Test Anal. 2013;5(5):372-376. https://doi.org/10.1002/dta.1471