Review of LGD-4033 (LIGANDROL)


Review of LGD-4033 (LIGANDROL)

LGD-4033, also known as  Ligandrol, is an investigational selective androgen receptor modulator (SARM) currently being studied for its potential to treat conditions such as muscle wasting and osteoporosis.

Buy LGD-4033 from Loti Labs, your trusted source for research liquids. It is sold in liquid form in 10 mg per ml vials and is intended as a research chemical, not for human consumption.

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LGD-4033 is a novel nonsteroidal, oral SARM that binds to androgen receptors with high affinity and selectivity. 

In animal models, LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and a robust selectivity for muscle versus prostate.

Unlike anabolic androgenic steroids, selective androgen receptor modulators (SARMs) have tissue-selective activities. They express anabolic effects in the bone and muscle tissues without causing androgenic side effects such as acne and prostate enlargement.


IUPAC Name: 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Molecular Formula: C14H12F6N2O

Molecular weight: 338.25 g/mol

CAS number: 1165910-22-4


LGD-4033 acts as a ligand that enters the cell by diffusion and attaches to the androgen receptor in the cytoplasm, forming a receptor/ligand complex that translocates to the nucleus, where it binds the DNA and acts as a transcriptional regulator of androgen-responsive genes.

It causes dose-dependent suppression of total testosterone, sex hormone–binding globulin, high-density lipoprotein cholesterol, and triglyceride levels after administration. Follicle-stimulating hormone and free testosterone showed significant suppression at 1 mg dose only.

LGD-4033 has a prolonged elimination half-life (24–36 hours).


LGD-4033 benefits include:

  • Increased lean body mass
  • Improved physical function
  • Treating muscle wasting
  • Suppressing HDL cholesterol
  • Decrease in Triglyceride levels
  • Increasing bone mineral density, periosteal bone formation, and femur bending strength in preclinical models


Common side of effects of LGD-4033 include:

  • Liver toxicity – diffuse itching, jaundice, acholic stool, intermittent abdominal pain that was associated with nausea, weight loss
  • Affecting blood lipid levels
  • Increasing the risk of heart attack
  • Stroke


When searching for research liquids online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research. 

Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy LGD-4033 for sale. 

Visit our website or contact us today to buy LGD-4033 online.


  1. Basaria S, Collins L, Dillon EL, Orwoll K, Storer TW, et al. (Jan 2013). “The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men”. J Gerontol A Biol Sci Med Sci. 68 (1): 87–95. doi:10.1093/gerona/gls078. PMC 4111291. PMID 22459616.
  1. “Ligand Presents New Preclinical Data on its Lead SARM Molecule LGD-4033 at the Gerontological Society of America Annual Meeting” (Press release). San Diego: Ligand Pharmaceuticals. November 20, 2009. Archived from the original on November 23, 2014. Retrieved November 23, 2014.
  1. Barbara M, Dhingra S, Mindikoglu AL. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J. 2020 Jun 11;7(6):e00370. doi: 10.14309/crj.0000000000000370. PMID: 32637435; PMCID: PMC7304490.

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