MK-677 is a potent, orally available non-peptide Growth Hormone -secretagogue mimetic, which binds to the ghrelin receptor and stimulates the secretion of GH

At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy MK-677 for sale only for research purposes and not for human consumption. It is available in liquid form at 25 mg per ml.

WHAT IS MK-677 (IBUTAMOREN)

MK-677 is a non-peptide spiropiperidine previously shown to be functionally and mechanically indistinguishable in vitro and in vivo from the potent peptide GHS GHRP-6. MK-677 elevates GH levels, as well as IGF-I and cortisol levels, in dogs after oral administration.

STRUCTURE OF MK-677 (IBUTAMOREN)

Molecular Formula: C₂₇H₃₆N₄O₅S

Molecular weight: 528.7 g/mol

CAS number: 159634-47-6

IUPAC name: 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide

MECHANISM OF ACTION

Liquid MK-677 (Ibutamoren) mimics the ghrelin hormone released in the stomach lining when hungry. Ghrelin binds itself to the growth hormone secretagogue-receptor type 1a (GHS-R1a), which increases appetite. This whole mechanism affects the pituitary and hypothalamus, which enhances growth and burns the fat associated with the thighs, waist, and abdomen in research subjects.

MK-677 (Ibutamoren) is active after oral administration in animals with a half-life of more than twenty (20) hours (almost 24 hours).

MK-677 (IBUTAMOREN) EFFECTS

Based on available research, the benefits of MK-677 (Ibutamoren)include:

• Strengthening muscle mass, preventing muscle loss
• Fat burning
• It strengthens bones and enhances bone density
• Reverses nitrogen waste
• It enhances sleep

MK-677 (IBUTAMOREN) SIDE EFFECTS

Below are what researchers noticed during clinical trials with MK-677 (Ibutamoren) use in animal test studies.

• water retention and swelling
• reduced insulin sensitivity and increased hunger
• joint and muscle pain
• headaches and migraines
• increased anxiety
• lethargy

LOOKING FOR WHERE TO BUY MK-677 (IBUTAMOREN) ONLINE

When searching for research peptides online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research. 

Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy MK-677 (Ibutamoren) for sale. 

Visit our website or contact us today to buy MK-677 (Ibutamoren) online.

References:

1. Murphy MG, Plunkett LM, Gertz BJ, He W, Wittreich J, Polvino WM, Clemmons DR. MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. J Clin Endocrinol Metab. 1998 Feb;83(2):320-5. doi: 10.1210/jcem.83.2.4551. PMID: 9467534.

2. The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture J. Am. Geriatr. Soc. (2004)

3. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretagogue (MK-677) in healthy elderly subjects J. Clin. Endocrinol. Metab.(1996)

1. Lee J, Kwon A, Chae HW, Lee WJ, Kim TH, Kim HS. Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats. Yonsei Med J. 2018 Dec;59(10):1174-1180. doi: 10.3349/ymj.2018.59.10.1174. PMID: 30450851; PMCID: PMC6240568.