How does Epitalon reverse aging in animal test studies?


How does Epitalon reverse aging in animal test studies?

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Epitalon is a peptide studied for its potential anti-aging effect. Most of its research is conducted in animals, so its potential health benefits and safety profile to humans is speculative. Studies show that epitalon may normalize age-related changes in the hormones, metabolism, and immunity, consequently slowing down the genetic program of aging. It may also be effective in preventing cancer.


Epitalon is also known as Epithalon or Epithalamine, a synthetic pineal tetrapeptide because it consists of four amino acids (Alanine, Glutamic acid, Aspartic acid, Glycine). It is identical to the natural peptide called Epithalamin, a hormone produced by the pineal gland.

It plays a role in metabolism, increasing the sensitivity of the hypothalamus to its natural hormone influences regulating the level of melatonin in the body of animal test subjects, which is responsible for improving the circadian rhythm. In testing epitalon has shown positive results in the areas of anti-aging, extending life expectancy and even in the inhibition of the proliferation of cancer cells (breast,colon and prostate).


Epitalon increases the production of telomerase, a natural enzyme that helps cells reproduce telomeres, which are the protective components of DNA and prevent the loss of genetic information resulting in the chromosome-shortening, which occurs in cell division. Telomeres get shorter every time a cell divides, and this is closely linked to age-related diseases, such as cardiovascular diseases, and ultimately death in elderly subjects.

If telomerase can be activated, cells can potentially exceed their time limit and continue to replicate reversing the mechanism of aging because the longer the telomere strand is, the better cell health and replication they provide. Therefore epitalon plays a vital role in decreasing the aging process and  may even extend longevity.


Studies show that scientists were able to tweak a gene to partially reverse age-related degeneration in mice. Before we delve further it is important to understand the concept of aging.


Cells perform specific roles in the body that are determined by their DNA. They have limited lifespans and leak toxins in their surroundings as they age. To protect the body, the aged cells undergo apoptosis, also known as programmed cell death. However, sometimes the aged cells, instead of dying, silently promote diseases in other tissues such as in the heart, liver, kidney, brains, etc. Scientists suspect that these cells may cause aging.


The research was carried out on genetically engineered mice that were altered to age prematurely, making them equivalent to 80-year-old humans and were ready to pass away. The animals had short, dysfunctional telomeres and suffered a range of age-related problems, such as atrophied spleens, damaged intestines, impaired sense of smell, shrunken brain, etc. The researchers hypothesized that early aging could be treated by boosting the activity of telomerase, an enzyme that makes small units of DNA (known as telomeres) which seal the tips of chromosomes preventing the genes inside them from unraveling.

The researchers administered epitalon to the mice, and a month later, the treated mice showed surprising signs of rejuvenation. Overall, their telomeres had lengthened, and the levels of telomerase increased. This made organs begin to function better. The treated mice regained their sense of smell, their spleen grew, the dormant brain stem cells produced new neurons, and also increased in size.

After the experiment, the treated mice were the physiological equivalent of young adults having a longer lifespan.

Clinical trials of the epitalon have demonstrated beneficial effects reflected by the improvement of the conditions of respective organs.


This breakthrough discovery shows that epitalon is a peptide that increases telomerase production and telomere strand length, which are primary factors with the potential to reverse aging.


You can purchase epitalon from Loti Labs. Buy peptides which are USA-made for the integrity of your research. It is tested through HPLC and Mass spectrometry to ensure quality. Epitalon is commonly sold in 10mg vials. It is available in lyophilized powder form.


  1. Callaway, E. Telomerase reverses aging process. Nature (2010).
  1. Khavinson, V.K., Bondarev, I.E. & Butyugov, A.A. Bulletin of Experimental Biology and Medicine (2003) 135: 590.
  1. Anisimov VN, Khavinson VKh, Alimova IN, Semchenko AV, Yashin AI. Epithalon decelerates aging and suppresses the development of breast adenocarcinomas in transgenic her-2/neu mice. Bull Exp Biol Med. 2002;134(2):187–190. doi:10.1023/a:1021104819170
  1. Khavinson VKh. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11–144.

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