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Liothyronine Sodium is a type of synthetic thyroid hormone that is used to enhance the metabolic rate, and impact the overall process of protein synthesis.

Chemically, Liothyronine Sodium is similar to triiodothyronine (T3). It works by targeting thyroid hormone receptor alpha and beta-one and works by increasing the body’s sensitivity towards catecholamines through permissiveness.

The compound has a molecular weight of 672.96 and should be stored at -20 degrees Celsius, ideally.

Chemical Mechanisms

Liothyronine Sodium is a synthetic formulation of the active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds itself to the nuclear thyroid hormone receptors. Subsequently, this leads to the binding of thyroid response elements, also known as TREs, in target genes.

This receptor binding along with the recruited coactivators result in maximal transcriptional activation, and repression of gene transcription.

According to various medical findings, Liothyronine Sodium plays an important role in the development and regulation of multiple metabolic processes responsible for functional homeostasis. When administered in high doses, it can lead to mild enzyme elevations.

Research Related to T3 (Liothyronine Sodium)

Levo-thyroxine is recommended to treat the causes of hypothyroidism. This is because it is deduced that deiodinase can help in restoring the T3 production and compensate for the lack of T3 that is normally produced by the thyroid gland. Clinical studies conducted on thyroidectomized rates have revealed that minimally reduced plasma T3 levels can play a vital role in dampening the TH signaling.

There are also pieces of evidence that suggest that TH signaling might not be fully normalized in patients treated with LT-4 hypothyroid.

The use of Liothyronine along with LT4 to improve the symptoms of hypothyroidism is not frequent, but it is highly preferred. (Reference 1)

Liothyronine Sodium Uses

Based on the studies conducted on animals, Liothyronine Sodium plays an important role in treating underactive thyroid, a condition which is also known as hypothyroidism. Liothyronine Sodium works by replacing thyroid hormones produced by the thyroid gland.

Additionally, the compound is also found to be effective against various other types of thyroid problems including thyroid cancer and goiter. In various cases, it is also used to treat infertility caused due to low thyroid hormone levels.

Liothyronine Sodium for Sale

You can explore a range of options when it comes to buying Liothyronine Sodium online. However, the clinical results and findings can be impacted if you buy Liothyronine Sodiumfrom an unauthentic source. It is important to ensure that you buy high-quality Liothyronine Sodium to get the desired results.

Loti Labs Liothyronine Sodiumgoes through a rigorous quality check process to ensure that it contributes to the findings in your research.

Other Liothyronine Sodium Uses

In addition to treating the conditions related to hypothyroidism, Liothyronine Sodium, in combination with other compounds, is used to treat the symptoms of obesity.

Depending on the circumstances, it might also be administered to treat fibromyalgia, fatigue, and depressive symptoms.

Liothyronine Sodium Effects

Various animal-based findings have revealed that the Liothyronine Sodium can lead to temporary hair loss during the first few months of consumption. The symptoms of too much thyroid hormone could also become pronounced. The related conditions include headache, sweating, mood changes, menstrual changes, sensitivity to heat, and diarrhea.

Buy Liothyronine Sodium for research by visiting Loti Labs!


Werneck de Castro JP, Fonseca TL, Ueta CB, McAninch EA, Abdalla S, Wittmann G, et al. Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest. (2015) 125:769–81. doi: 10.1172/JCI77588

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