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GROWTH HORMONE RELEASING PEPTIDE-2

GROWTH HORMONE RELEASING PEPTIDE-2

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GROWTH HORMONE RELEASING PEPTIDE-2

A BRIEF INTRODUCTION OF GHRPs

Growth hormone-releasing peptides-2 GHRPs are synthetic, non-natural peptides with potent stimulatory effects on Growth hormone secretion in animal test subjects. They have no structural resemblance with Growth Hormone-Releasing Hormone and act through specific receptors present at the pituitary or hypothalamic level in animals. 

The GH-releasing activity of GHRPs is noticeable and dose-related after intravenous subcutaneous intranasal and oral administration.

Though the way GHRPs work is still a blur, available data postulates that they could act by counteracting somatostatinergic activity both at the pituitary and hypothalamic level and partially through a GHRH-mediated mechanism.

Recently, GHRP-2 was synthesized and is also available for animal studies. Growth Hormone Releasing Peptide-2 (GHRP-2) is a potent member of the Growth Hormone Releasing Peptide family, closely related to GHRP-6, a hexapeptide of an earlier generation.

GHRP-2 is available in lyophilized powder form and sold in 5 mg vials.

At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy GHRP-2 for sale for research purposes only and not for human consumption.

WHAT IS GROWTH HORMONE RELEASING PEPTIDE-2

Growth Hormone Releasing Peptide-2, also referred to as Pralmorelin or KP-102, is a new 2nd generation synthetic hexapeptide containing six amino acids, D-Alanyl-3-(2-naphthalenyl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide.

GHRP-2 studies in animals show its functionality as a growth hormone secretagogue (GHS). It is a synthetic agonist of the hormone ghrelin, a newly-discovered gut peptide that binds to the growth hormone secretagogue receptor). 

Ghrelin has two unique effects, stimulating both GH secretion and appetite initiation.

MECHANISM OF ACTION

The mechanism of action of GHRP-2 on GH release was investigated in experimental animals. 

GHRP-2 was found to stimulate GH release from rat pituitary cells via the same receptor, with a slight variation when compared to GHRP-6. GHRP-2 increases intracellular adenosine 3,5-monophosphate cAMP concentration like that of Growth Releasing Factor (GRF) while GHRP-6 causes a decrease in cAMP levels.

GROWTH HORMONE RELEASING PEPTIDE-2 EFFECTS

The theoretical benefits of GHRP-2 on animal test subjects show that it:

  • Increases lipolysis
  • Increases muscle mass
  • Speeds up wound healing
  • Promotes heart health
  • Decreases inflammation of the liver
  • Pain relief
  • Improves lung injury
  • Improves sleep
  • Increases bone density
  • Improves immunity

GHRP-2 SIDE EFFECTS

Some of its theoretical side effects are:

  • Water retention
  • Elevated levels of cortisol and prolactin
  • A feeling of lethargy and tiredness
  • Decreased insulin sensitivity
  • Tingling and numbness

LOOKING FOR WHERE TO BUY GHRP-2 ONLINE

When searching for research peptides online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research. 

Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy GHRP-2 for sale. 

Visit our website or contact us today to buy GHRP-2 online.

References:

  1. Argente J, García-Segura LM, Pozo J, Chowen JA. Growth hormone-releasing peptides: clinical and basic aspects. Horm Res. 1996;46(4-5):155–159. doi:10.1159/000185015
  1. Ghigo E, Arvat E, Muccioli G, Camanni F. Growth hormone-releasing peptides. Eur J Endocrinol. 1997;136(5):445–460. doi:10.1530/eje.0.1360445
  1. Peroni CN, Hayashida CY, Nascimento N, et al. Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient little mice. Clinics (Sao Paulo). 2012;67(3):265–272. doi:10.6061/clinics/2012(03)11
  1. Liu C, Huang J, Li H, et al. Ghrelin accelerates wound healing through GHS-R1a-mediated MAPK-NF-κB/GR signaling pathways in combined radiation and burn injury in rats. Sci Rep. 2016;6:27499. Published 2016 Jun 7. doi:10.1038/srep27499

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