GROWTH HORMONE RELEASING PEPTIDE-2
05December 5, 2022
GROWTH HORMONE RELEASING PEPTIDE-2
Definition and Classification
GHRP-2, also known as Growth Hormone Releasing Peptide-2, is a synthetic agonist of ghrelin, a gut peptide that binds to the growth hormone secretagogue receptor (GHSR). It is a member of the growth hormone releasing peptide family, which includes other peptides such as GHRP-6 and ipamorelin. GHRP-2 is classified as a growth hormone secretagogue, a class of compounds that stimulate the release of growth hormone from the pituitary gland. This classification underscores its role in enhancing growth hormone secretion, making it a valuable tool in research focused on growth hormone dynamics.
A BRIEF INTRODUCTION OF GHRPs
Growth hormone-releasing peptides-2 GHRPs are synthetic, non-natural peptides with potent stimulatory effects on Growth hormone secretion in animal test subjects. They have no structural resemblance with Growth Hormone-Releasing Hormone and act through specific receptors present at the pituitary or hypothalamic level in animals.
The GH-releasing activity of GHRPs is noticeable and dose-related after intravenous subcutaneous intranasal and oral administration.
Though the way GHRPs work is still a blur, available data postulates that they could act by counteracting somatostatinergic activity both at the pituitary and hypothalamic level and partially through a GHRH-mediated mechanism.
Recently, GHRP-2 was synthesized and is also available for animal studies. Growth Hormone Releasing Peptide-2 (GHRP-2) is a potent member of the Growth Hormone Releasing Peptide family, closely related to GHRP-6, a hexapeptide of an earlier generation.
GHRP-2 is available in lyophilized powder form and sold in 5 mg vials.
At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy GHRP-2 for sale for research purposes only and not for human consumption.
WHAT IS GROWTH HORMONE RELEASING PEPTIDE-2
Growth Hormone Releasing Peptide-2, also referred to as Pralmorelin or KP-102, is a new 2nd generation synthetic hexapeptide containing six amino acids, D-Alanyl-3-(2-naphthalenyl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide.
GHRP-2 studies in animals show its functionality as a growth hormone secretagogue (GHS). Studies have shown that GHRP-2 is effective in promoting the secretion of human growth hormone (hGH), which has significant implications for treating hormone deficiencies. It is a synthetic agonist of the hormone ghrelin, a newly-discovered gut peptide that binds to the growth hormone secretagogue receptor).
Ghrelin has two unique effects, stimulating both GH secretion and appetite initiation.
MECHANISM OF ACTION
The mechanism of action of GHRP-2 on GH release was investigated in experimental animals. GHRP-2’s mechanism of action involves interactions with growth hormone secretagogues and gh releasing hormone, which play crucial roles in regulating food intake and hormonal responses.
GHRP-2 was found to stimulate GH release from rat pituitary cells via the same receptor, with a slight variation when compared to GHRP-6. GHRP-2 increases intracellular adenosine 3,5-monophosphate cAMP concentration like that of Growth Releasing Factor (GRF) while GHRP-6 causes a decrease in cAMP levels.
Binding to GHSR Receptors
GHRP-2 binds to the GHSR receptor, which is a G-protein coupled receptor that is expressed in the pituitary gland and other tissues. The binding of GHRP-2 to the GHSR receptor activates a signaling cascade that ultimately leads to the release of growth hormone from the pituitary gland. The GHSR receptor is also activated by ghrelin, a natural peptide hormone that is produced in the stomach and plays a role in regulating food intake and energy balance. This interaction highlights the dual role of GHRP-2 in both growth hormone release and the regulation of appetite.
Stimulating Growth Hormone Release
GHRP-2 stimulates the release of growth hormone from the pituitary gland by activating the GHSR receptor. This leads to an increase in serum GH levels, which can have a number of effects on the body, including increased muscle mass, bone density, and fat loss. GHRP-2 has been shown to be effective in stimulating GH release in both healthy individuals and those with GH deficiency. This makes it a significant focus of research for understanding and potentially treating conditions related to growth hormone deficiency.
GROWTH HORMONE RELEASING PEPTIDE-2 EFFECTS
The theoretical benefits of GHRP-2 on animal test subjects show that it:
Increases lipolysis
Increases muscle mass
Speeds up wound healing
Promotes heart health
Decreases inflammation of the liver
Pain relief
Improves lung injury
Improves sleep
Increases bone density
Improves immunity
GHRP-2 has been shown to significantly enhance GH secretion, which contributes to its various beneficial effects on animal test subjects.
RESEARCH STUDIES
J Clin Endocrinol Metab Studies on GHRP-2
Several studies have been published in the Journal of Clinical Endocrinology and Metabolism (J Clin Endocrinol Metab) on the effects of GHRP-2 on growth hormone release and food intake. One study found that GHRP-2 infusion increased food intake in healthy men, with a significant increase in energy intake and a trend towards increased fat intake. Another study found that GHRP-2 administration increased serum GH levels in healthy men, with a peak GH response occurring 15-30 minutes after administration. A third study found that GHRP-2 infusion increased GH release in obese men, with a significant increase in serum GH levels and a trend towards increased insulin-like growth factor-1 (IGF-1) levels.
These studies demonstrate the effectiveness of GHRP-2 in stimulating GH release and increasing food intake, and suggest that it may be a useful tool for investigating the effects of ghrelin on eating behavior and GH secretion in humans. However, further research is needed to fully understand the effects of GHRP-2 on GH release and food intake, and to determine its potential therapeutic applications.
GHRP-2 SIDE EFFECTS
Some of its theoretical side effects are:
Water retention
Elevated levels of cortisol and prolactin
A feeling of lethargy and tiredness
Decreased insulin sensitivity
Tingling and numbness
As a growth hormone releasing hexapeptide, GHRP-2 may have several theoretical side effects, including water retention and elevated levels of cortisol and prolactin.
LOOKING FOR WHERE TO BUY GHRP-2 ONLINE
When searching for research peptides online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research. Loti Labs offers a variety of gh releasing peptides, including GHRP-2, for research purposes.
Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy GHRP-2 for sale.
Visit our website or contact us today to buy GHRP-2 online.
References:
Argente J, García-Segura LM, Pozo J, Chowen JA. Growth hormone-releasing peptides: clinical and basic aspects. Horm Res. 1996;46(4-5):155–159. doi:10.1159/000185015
Ghigo E, Arvat E, Muccioli G, Camanni F. Growth hormone-releasing peptides. Eur J Endocrinol. 1997;136(5):445–460. doi:10.1530/eje.0.1360445
Peroni CN, Hayashida CY, Nascimento N, et al. Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient little mice. Clinics (Sao Paulo). 2012;67(3):265–272. doi:10.6061/clinics/2012(03)11
Liu C, Huang J, Li H, et al. Ghrelin accelerates wound healing through GHS-R1a-mediated MAPK-NF-κB/GR signaling pathways in combined radiation and burn injury in rats. Sci Rep. 2016;6:27499. Published 2016 Jun 7. doi:10.1038/srep27499
