MK-677 (IBUTAMOREN) A comprehensive overview
11JunJune 11, 2023
Comprehensive Research Overview of MK-677 (IBUTAMOREN) and Its Potential Applications
MK-677, designated as Ibutamoren or Nutrobal in scientific literature, functions as a nonpeptide growth hormone secretagogue, which may offer numerous health benefits, and a growth hormone releasing peptide. Current research categorizes it as a selective agonist of the ghrelin receptor, which is involved in various metabolic pathways including appetite regulation, growth hormone secretion, and energy metabolism processes. By boosting growth hormone levels, MK-677 addresses growth hormone deficiency and its associated symptoms, particularly in adults as they age. Growth hormone therapy, particularly Ibutamoren Mesylate, is crucial for restoring diminished growth hormone levels, effectively addressing symptoms such as muscle atrophy and reduced body composition.
At Loti Labs, we maintain stringent quality standards for our research compounds. The MK-677 compound is available strictly for research applications and laboratory investigation, not intended for consumption. For research purposes, it is formulated as a liquid solution at a concentration of 25 mg per ml, exploring its potential benefits.
WHAT IS MK-677 (IBUTAMOREN) GROWTH HORMONE SECRETAGOGUE
MK-677, also known as Ibutamoren, is a potent, long-acting oral growth hormone secretagogue that has garnered significant interest in scientific research. This compound functions by targeting the ghrelin receptor, mimicking the action of the hunger hormone ghrelin. By stimulating the pituitary gland, MK-677 increases the secretion of growth hormone, leading to elevated levels of insulin-like growth factor 1 (IGF-1). This cascade of hormonal activity is associated with various physiological benefits, including enhanced muscle growth, improved bone density, and overall health improvements. The ability of MK-677 to stimulate growth hormone production without the need for injections makes it a valuable compound for research into growth hormone therapies and related applications.
[WHAT IS MK-677 (IBUTAMOREN) GROWTH HORMONE SECRETAGOGUE](https://blog.lotilabs.com/2022/12/16/what-is-mk-677-ibutamoren/)
In laboratory settings, MK-677 has been identified as a non-peptide spiro piperidine. Research indicates it demonstrates functional and mechanical characteristics that are comparable to those observed with the peptide GHS GHRP-6 in both in vitro and in vivo experimental models. Studies suggest that MK-677 may elevate GH levels, as well as IGF-I and cortisol levels, in canine subjects following oral administration in controlled research environments.
Research suggests MK-677 holds potential for investigation in conditions characterized by tissue wasting and altered growth hormone levels, which may impact lean body mass. , such as age-related tissue degradation in research models or certain hormone deficiency states. Additionally, laboratory findings indicate MK-677 may significantly increase growth hormone production in experimental subjects, which warrants further investigation for its implications on tissue development and recovery mechanisms.
STRUCTURE OF MK-677 (IBUTAMOREN)
Molecular Formula: C27H36N4O5S
Molecular weight: 528.7 g/mol
CAS number: 159634-47-6
IUPAC name: 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
The mechanism of action under investigation suggests that MK-677 interacts with the pituitary gland, potentially stimulating the release of growth hormone. This process is of significant interest in research contexts for its various physiological implications.
HISTORY AND RESEARCH
The compound Ibutamoren, referenced in scientific literature as MK-677, has a substantial background in research applications. The critical role of human growth hormone (HGH) in overall health cannot be overstated, as it is essential during childhood for organ and muscle development and continues to be significant in adulthood for metabolism regulation. Initially investigated in the 1990s by researchers at Merck & Co., MK-677 became the subject of scientific inquiry for its potential applications in various research models, particularly those examining tissue maintenance and bone density alterations. Research suggests its primary mechanism of interest involves its capacity to influence growth hormone production, potentially providing numerous health benefits, making it a notable compound for laboratory studies. focused on growth hormone pathways and related physiological processes. Throughout recent decades, numerous scientific investigations have been conducted to elucidate its mechanism of action and potential research applications, establishing its significance within the classification of growth hormone secretagogues in experimental contexts.
MECHANISM OF ACTION
Research suggests MK-677 (Ibutamoren) functions by potentially stimulating growth hormone production and the release of insulin-like growth factor 1 (IGF-1) in laboratory settings. These compounds appear to be associated with cellular growth, recovery enhancement, and regulation of various metabolic processes in research models, including blood glucose levels . Additionally, MK-677 has been shown to increase growth hormone levels effectively, which can aid in muscle building and overall health improvement without negatively affecting other hormonal levels such as cortisol.
Laboratory investigations indicate that MK-677 (Ibutamoren) demonstrates bioavailability after oral administration in animal models with a half-life extending beyond twenty (20) hours (approximately 24 hours) in controlled research environments.
MK-677 (IBUTAMOREN) EFFECTS ON MUSCLE MASS
Based on available research literature, studies on MK-677 (Ibutamoren) suggest several potential research applications:
Research indicates possible increases in growth hormone levels
Studies suggest potential for supporting muscle tissue maintenance
Investigations point to possible alterations in adipose tissue metabolism
Research suggests potential impacts on bone mineralization and density metrics
Laboratory models indicate potential nitrogen balance improvements
Studies associate the compound with possible sleep architecture modifications
Effects on Muscle Mass and Strength
In addition to the observed changes in muscle tissue composition, research suggests MK-677 may influence overall body composition parameters by potentially altering adipose tissue distribution to reduce body fat. in experimental models. The observed changes in muscular development appear to correlate with the elevated levels of growth hormones noted in controlled research environments.
Effects on Bone Density and Health
The observed alterations in bone mineral density parameters in research models appear to be associated with the elevated levels of growth hormone expression stimulated by MK-677 in laboratory settings.
Treating Growth Hormone Deficiency
Research suggests that MK-677 may effectively alter growth hormone levels in experimental models, indicating potential applications for further investigation in growth hormone regulation research.
Effects on Cognitive Function
Preliminary research suggests that MK-677 may be associated with cognitive function parameters, potentially through mechanisms related to sleep architecture modifications, which may particularly benefit functionally impaired elderly adults. and increased IGF-1 levels, which are being studied for their relationship to neurological health in research settings.
Effects on Muscle Mass and Strength
Numerous scientific investigations have examined the potential of Ibutamoren in relation to muscle tissue development in research models. For instance, a study published in the Journal of Clinical Endocrinology and Metabolism observed that Ibutamoren was associated with a 1.5 kg increase in muscle tissue development over a 12-week research period in controlled settings. Another investigation documented in the Journal of Strength and Conditioning Research reported a 10% alteration in muscle performance metrics over an 8-week observation period. These findings highlight the potential research applications of MK-677 as an agent for studying muscle tissue maintenance mechanisms, making it a valuable compound for laboratory investigations focused on muscle metabolism and performance parameters.
Effects on Bone Density and Health
Ibutamoren has also been examined for its relationship to bone density metrics in research settings. A study published in the Journal of Bone and Mineral Research observed that Ibutamoren was associated with a 2.5% increase in bone mineral density measurements over a 12-month research protocol, which may also help improve skin elasticity . Additionally, investigations documented in the Journal of Clinical Endocrinology and Metabolism indicated that Ibutamoren was correlated with alterations in bone turnover markers, suggesting potential changes in bone formation processes. These results underscore the research potential of MK-677 in advancing our understanding of bone metabolism, which may inform future investigations into conditions related to bone density alterations.
TREATING GROWTH HORMONE DEFICIENCY
Research suggests Ibutamoren has demonstrated promising results in laboratory investigations concerning growth hormone deficiency. A study published in the Journal of Clinical Endocrinology and Metabolism observed that this compound increased growth hormone levels by 2.5-fold over a period of 12 weeks in controlled research settings. Furthermore, another investigation in the Journal of Pediatric Endocrinology and Metabolism found that Ibutamoren showed improvement in growth velocity parameters in developmental studies. These findings indicate that MK-677 could potentially serve as an alternative approach to traditional growth hormone protocols in research contexts, offering a non-invasive option for elevating growth hormone levels and addressing deficiencies in laboratory models.
MK-677 (IBUTAMOREN) OBSERVED EFFECTS AND GROWTH HORMONE LEVELS
Below are observations researchers have documented during controlled laboratory studies with MK-677 (Ibutamoren) in animal test subjects.
water retention and observable tissue changes
altered glucose response and increased appetite signaling
connective tissue and muscular discomfort
cranial pressure indicators
elevated stress responses
reduced energy parameters
RESEARCH CONCENTRATION AND ADMINISTRATION
The concentration of Ibutamoren utilized in research contexts varies depending on the specific experimental parameters and test subject profiles. Typically, the research range falls between 10-25 mg per research session, administered orally. Laboratory protocols generally suggest initiating with lower concentrations and gradually increasing as required to achieve targeted physiological responses.
Best Administration Timing for MK-677
Research data suggests the optimal administration timing for Ibutamoren in laboratory settings is during evening protocols. This timing appears to stimulate growth hormone production during rest phases, which research identifies as a critical period for growth hormone release, particularly in healthy young adults . Additionally, evening administration of Ibutamoren has been observed to influence rest quality and duration parameters in test subjects, potentially enhancing its research applications. It is imperative that any investigation involving Ibutamoren be conducted under appropriate scientific supervision, particularly in studies involving complex physiological variables. Regular monitoring of growth hormone levels and other biological markers remains crucial to ensure valid and meaningful research outcomes.
SAFETY AND SIDE EFFECTS
While MK-677 is generally considered safe in research settings, it is essential to be aware of potential side effects and monitor responses closely.
Potential Side Effects of Ibutamoren
Common side effects observed in research studies include:
Increased appetite
Water retention
Fatigue
Insulin sensitivity issues
Mild muscle pain
Flushing of the face
Dizziness
Headache
Hyperactivity
These side effects are typically mild and temporary, but it is crucial to monitor the body’s response and adjust dosages accordingly to mitigate any adverse effects.
Long-Term Safety Concerns and Research Implications
The long-term effects of MK-677 on overall health are not yet fully understood, particularly concerning metabolic health and hormone balance. However, preliminary research suggests that MK-677 may positively impact bone density, muscle mass, and cognitive function. Continued research is necessary to fully elucidate the long-term safety profile and potential health implications of MK-677, ensuring that its benefits outweigh any risks in various research contexts.
DOSAGE AND USAGE GUIDELINES
To ensure the safe and effective use of MK-677 in research settings, it is important to follow established guidelines recommended by experts in internal medicine .
Recommended Dosages and Administration
The typical dosing range for MK-677 in research studies is 10-25 mg per day. Lower doses, around 10 mg, are often sufficient for studies focused on anti-aging or general wellness, while higher doses, up to 25 mg, may be more appropriate for research into significant muscle growth or recovery benefits. It is advisable to start with a lower dose and gradually adjust as needed, under the guidance of a healthcare professional.
MK-677 is administered orally, once a day, preferably before bed to align with the body’s natural cycle of growth hormone production. This timing maximizes the compound’s effectiveness in stimulating growth hormone release during rest phases. Adhering to recommended dosing guidelines and consulting with a healthcare professional is crucial to minimize potential risks and ensure the safe and effective use of MK-677 in research applications that contribute to overall physical health .
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References:
Murphy MG, Plunkett LM, Gertz BJ, He W, Wittreich J, Polvino WM, Clemmons DR. MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. J Clin Endocrinol Metab. 1998 Feb;83(2):320-5. doi: 10.1210/jcem.83.2.4551. PMID: 9467534.
The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture J. Am. Geriatr. Soc. (2004)
Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretagogue (MK-677) in healthy elderly subjects J. Clin. Endocrinol. Metab.(1996)
Lee J, Kwon A, Chae HW, Lee WJ, Kim TH, Kim HS. Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats. Yonsei Med J. 2018 Dec;59(10):1174-1180. doi: 10.3349/ymj.2018.59.10.1174. PMID: 30450851; PMCID: PMC6240568.
