Review of Exemestane – Buy Exemestane Liquid 25mg per ml (30ml)
27March 27, 2023
Review of Exemestane – Buy Exemestane Liquid 25mg per ml (30ml)
Exemestane is a highly specific steroidal aromatase inhibitor that stops the in vivo conversion of androstenedione to oestrone (aromatization). It is the newest agent in this class.
At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy exemestane (Aromasin) for sale only for research purposes and not for human consumption. It is available in liquid form at 25 mg per ml.
[What is Exemestane? Benefits, Uses, and Side Effects of This Aromatase Inhibitor Explained](https://blog.lotilabs.com/2023/02/13/what-is-exemestane-buy-exemestane-25mg-per-ml/)
Exemestane belongs to the class of antiestrogens known as aromatase inhibitors. Exemestane effectively inhibits human placental aromatase activity, demonstrating its potential impact on estrogen production. It irreversibly binds to the active site of the enzyme and this property has resulted in its use in the adjuvant treatment of hormonally-responsive breast cancer in postmenopausal rats. The potency of exemestane is highlighted by its low Ki value, indicating its effectiveness in inhibiting aromatase activity.
STRUCTURE OF EXEMESTANE
Molecular Formula: C20H24O2
Molecular weight: 296.4 g/mol
CAS number: 107868-30-4
IUPAC name: (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
Exemestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the peripheral aromatization of androgens, including androstenedione and testosterone, to estrogens. This lowers estrogen levels in blood circulation.
Exemestane appeared to be more rapidly absorbed in the rats with breast cancer than in the healthy rats.
EXEMESTANE USES AND APPLICATIONS
Exemestane is a versatile medication with various uses and applications, primarily in the treatment of breast cancer. As an aromatase inhibitor, it plays a crucial role in reducing estrogen levels in the body, which can help slow the growth of certain types of breast tumors. By inhibiting the enzyme aromatase, exemestane effectively decreases the synthesis of estrogen, making it a valuable tool in managing hormone-receptor-positive breast cancer. This medication is particularly beneficial for postmenopausal individuals, as it helps to prevent the recurrence of cancer by maintaining lower estrogen levels. Additionally, exemestane is used in research settings to study its effects on estrogen synthesis and its potential applications in other hormone-related conditions.
EXEMESTANE EFFECTS ON BREAST CANCER
Exemestane’s benefits include the following:
Decreasing the amount of estrogen the body makes helps to slow or reverse the growth of these breast cancers.
Treatment of certain types of breast cancer (such as hormone-receptor-positive breast cancer) in menopausal animals
Prevention of a recurrence of cancer.
EXEMESTANE SIDE EFFECTS
The side effects of exemestane include:
Headache
Nausea
Fatigue
Hot flashes
Sweating
Insomnia
Joint pain
LOOKING FOR WHERE TO BUY EXEMESTANE ONLINE
When searching for research liquids online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research.
When taking exemestane, it is important to follow prescribed guidelines and consult with healthcare professionals.
Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy exemestane for sale.
Visit our website or contact us today to buy exemestane online.
Coombes RC, Kilburn LS, Snowdon CF, Paridaens R, Coleman RE, Jones SE, Jassem J, Van de Velde CJ, Delozier T, Alvarez I, Del Mastro L, Ortmann O, Diedrich K, Coates AS, Bajetta E, Holmberg SB, Dodwell D, Mickiewicz E, Andersen J, Lonning PE, Cocconi G, Forbes J, Castiglione M, Stuart N, Stewart A, Fallowfield LJ, Bertelli G, Hall E, Bogle RG, Carpentieri M, Colajori E, Subar M, Ireland E, Bliss JM: Survival and safety of exemestane versus tamoxifen after 2-3 years’ tamoxifen treatment (Intergroup Exemestane Study): a randomized controlled trial. Lancet. 2007 Feb 17;369(9561):559-70. [Article]
Robinson A: A review of the use of exemestane in early breast cancer. Ther Clin Risk Manag. 2009 Feb;5(1):91-8. Epub 2009 Mar 26. [Article]
Untch M, Jackisch C: Exemestane in early breast cancer: a review. Ther Clin Risk Manag. 2008 Dec;4(6):1295-304. [Article]
Abrial C, Durando X, Mouret-Reynier MA, Thivat E, Bayet-Robert M, Nayl B, Dubray P, Pomel C, Chollet P, Penault-Llorca F: Role of neo-adjuvant hormonal therapy in the treatment of breast cancer: a review of clinical trials. Int J Gen Med. 2009 Jul 30;2:129-40. [Article]
