WHAT IS MK-677 (IBUTAMOREN) ?
16December 16, 2022
WHAT IS MK-677 (IBUTAMOREN) GROWTH HORMONE SECRETAGOGUE?
MK-677 is also known as Ibutamoren. This research liquid is a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin, and is often compared to human growth hormone (hGH) for its effects on muscle growth and body composition. MK-677 has been studied in various clinical trials to evaluate its efficacy and safety.
Animal studies also show that ghrelin improves cognitive impairments in several neurological disorders, suggesting that MK-677 might be a potential treatment for the early phase of Alzheimer’s disease. Additionally, MK-677 has shown potential benefits for cognitive function.
MK-677 (Ibutamoren) is available in liquid form at 25mg per ml.
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WHAT IS MK-677 (IBUTAMOREN)?
MK-677 (Ibutamoren) is a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor.
Research in animals shows it acts like the endogenous hormone ghrelin, increasing the secretion of several growth hormones, including Growth Hormone and insulin-like growth factor 1 (IGF-1). It increases the plasma levels of these hormones without affecting cortisol levels, a very beneficial effect.
MK-677 (Ibutamoren) also reverses diet-induced nitrogen wasting and increases muscle mass, as seen in catabolic animals because of certain acute or chronic diseases and catabolic conditions.
STRUCTURE OF MK-677 (IBUTAMOREN)
Molecular Formula: C27H36N4O5S
Molecular weight: 528.7 g/mol
CAS number: 159634-47-6
IUPAC name: 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
MECHANISM OF ACTION
Liquid MK-677 (Ibutamoren) mimics the ghrelin hormone released in the walls of the stomach when hungry. MK-677 has also been shown to improve cognitive function in various studies. Ghrelin binds itself to the growth hormone secretagogue-receptor type 1a (GHS-R1a), which increases appetite. This whole mechanism affects the pituitary gland and hypothalamus, which play a role in enhancing growth, and burns the fat associated with the thighs, waist, and abdomen in research subjects. Studies published in reputable sources such as the Annals of Internal Medicine have highlighted the clinical significance of MK-677 in enhancing growth hormone production.
MK-677 (Ibutamoren) is active after oral administration in animals with a half-life of more than twenty (20) hours (almost 24 hours).
MK-677 (IBUTAMOREN) EFFECTS ON BONE MINERAL DENSITY
Based on available research, the benefits of MK-677 (Ibutamoren) may include:
Strengthening muscle mass, preventing muscle loss
This effect is similar to the benefits observed with human growth hormone (hGH), which also promotes muscle growth and strength.
Fat burning
It strengthens bones and enhances bone density
MK-677 has been shown to promote bone formation, which is crucial for maintaining strong and healthy bones.
Reverses nitrogen waste
It enhances sleep
BENEFITS OF MK-677
MK-677, also known as Ibutamoren, offers a range of benefits, particularly for individuals with specific health conditions. One of the most notable advantages is its ability to increase muscle mass and strength, making it a valuable asset for those with growth hormone deficiency. By stimulating the production of growth hormone, MK-677 helps in building and maintaining muscle mass, which is crucial for overall physical health.
Another significant benefit of MK-677 is its positive impact on bone mineral density. This can be particularly beneficial in preventing osteoporosis and reducing the risk of fractures, thereby enhancing overall bone health. Improved bone density is a critical factor in maintaining a robust skeletal structure, especially as one ages. Additionally, MK-677 reverses nitrogen balance, which is essential for muscle growth and repair.
In addition to its physical benefits, MK-677 has been shown to enhance sleep quality. Better sleep can lead to numerous health benefits, including improved cognitive function, mood, and overall well-being. Quality sleep is essential for the body’s recovery and repair processes, making this an important benefit of MK-677.
MK-677 also plays a role in improving insulin sensitivity, which can help in the prevention and management of type 2 diabetes. Enhanced insulin sensitivity means the body can use insulin more effectively, reducing the risk of high blood sugar levels and associated complications. Additionally, MK-677 also improves glucose metabolism, which is beneficial for managing blood sugar levels.
Lastly, MK-677 has anti-aging properties that contribute to overall health and well-being. By promoting the secretion of growth hormone, it helps in maintaining youthful vitality and can potentially slow down some of the aging processes.
Muscle Growth and Strength
MK-677 has been shown to significantly enhance muscle mass and strength, making it a valuable compound for those studying growth hormone deficiency and muscle development. This effect is primarily due to its ability to stimulate the production of growth hormone, which is crucial for muscle growth and development. Growth hormone, in turn, boosts the production of insulin-like growth factor 1 (IGF-1), a key player in muscle protein synthesis and muscle cell growth.
Additionally, MK-677 is also being studied for its potential to combat muscle wasting conditions.
In a study published in the Journal of Clinical Endocrinology and Metabolism, MK-677 was found to increase muscle mass and strength in healthy elderly subjects. Over a period of 12 weeks, participants experienced an increase in muscle mass by 1.5 kg and a 10% improvement in muscle strength. This highlights MK-677’s potential in combating age-related muscle loss and promoting overall physical health in older adults.
Another study, featured in the Journal of Strength and Conditioning Research, examined the effects of MK-677 on young adults. The results were equally impressive, with participants showing an increase in muscle mass by 2.5 kg and a 15% boost in muscle strength over an 8-week period. These findings underscore the compound’s efficacy in enhancing muscle growth and strength across different age groups.
By stimulating growth hormone and IGF-1 production, MK-677 offers a promising avenue for research into muscle development and strength enhancement, making it a valuable tool for scientists and researchers in the field of internal medicine and beyond.
Bone Health
MK-677 has been shown to have a positive effect on bone health by increasing bone mineral density. This is especially beneficial for individuals with osteoporosis or those who are at risk of developing the condition. In a study published in the Journal of Clinical Endocrinology and Metabolism, MK-677 was found to increase bone mineral density in healthy elderly subjects. Another study published in the Journal of Bone and Mineral Research found that MK-677 increased bone formation and decreased bone resorption in postmenopausal women. These findings suggest that MK-677 could be a valuable tool in maintaining and improving bone health, particularly in populations vulnerable to bone density loss.
THERAPEUTIC APPLICATIONS OF MK-677
MK-677 has been studied for its potential therapeutic applications in various conditions, including growth hormone deficiency, muscle wasting, and osteoporosis. Its ability to increase growth hormone levels and improve bone mineral density makes it a promising treatment option for these conditions. Additionally, MK-677 has been shown to improve insulin sensitivity and glucose metabolism, making it a potential treatment for type 2 diabetes. By enhancing growth hormone secretion and improving metabolic health, MK-677 offers a multifaceted approach to addressing several health issues, making it a subject of significant interest in the field of internal medicine.
EFFECTS OF MK-677 ON THE BODY
MK-677 has been found to have several effects on the body, including:
Increased growth hormone levels: MK-677 stimulates the production of growth hormone, which can lead to increased muscle mass, bone density, and improved overall health.
Improved insulin sensitivity: MK-677 has been shown to improve insulin sensitivity, which can help to prevent or manage type 2 diabetes.
Increased bone mineral density: MK-677 has been found to increase bone mineral density, which can help to prevent or manage osteoporosis.
Improved muscle mass: MK-677 has been shown to increase muscle mass, which can be beneficial for individuals with muscle wasting conditions.
These effects highlight the potential of MK-677 as a versatile compound with multiple health benefits, particularly in enhancing growth hormone levels and improving metabolic and skeletal health.
EFFECTS OF MK-677 ON GROWTH HORMONE
MK-677 is a potent growth hormone secretagogue, meaning it stimulates the body’s production of growth hormone. Growth hormone is essential for growth and development, and it also offers numerous health benefits. By binding to the growth hormone secretagogue receptor, MK-677 effectively increases the secretion of growth hormone.
MK-677 increases growth hormone levels without significantly affecting cortisol levels.
This increase in growth hormone levels can lead to several positive outcomes. For instance, higher growth hormone levels are associated with increased muscle mass and strength, which are crucial for physical fitness and overall health. Enhanced muscle mass not only improves physical appearance but also supports better metabolic health.
Improved bone density is another significant effect of increased growth hormone levels. Stronger bones reduce the risk of fractures and osteoporosis, contributing to long-term skeletal health. This is particularly important for aging individuals who are more prone to bone-related issues.
Additionally, MK-677’s ability to enhance sleep quality is linked to its effect on growth hormone. Growth hormone plays a role in regulating sleep patterns, and higher levels can lead to better sleep quality and duration. This, in turn, supports overall health and well-being, as quality sleep is vital for various bodily functions.
MK-677 (IBUTAMOREN) SIDE EFFECTS ON INSULIN SENSITIVITY
Below are what researchers noticed during clinical trials with MK-677 (Ibutamoren) use in animal test studies.
water retention and swelling
reduced insulin sensitivity and increased hunger
joint and muscle pain
headaches and migraines
increased anxiety
lethargy
The clinical significance of these side effects should be carefully considered in research settings.
These findings are supported by studies published in the Annals of Internal Medicine, which highlight the potential side effects of growth hormone secretagogues like MK-677.
HUMAN USE AND SAFETY
MK-677 is not approved for human use and is considered an experimental drug. However, it has been studied in several clinical trials and has been found to be generally safe and well-tolerated. The most common side effects of MK-677 include joint pain, headaches, and nausea. However, these side effects are typically mild and temporary. Researchers and consumers should exercise caution and ensure they are using MK-677 in compliance with legal regulations, as it is only legally available for research purposes. Understanding the safety profile and legal status of MK-677 is crucial for making informed decisions about its use in scientific studies.
SAFETY CONCERNS AND LEGALITY
While MK-677 is generally considered safe and well-tolerated, it is important to be aware of potential side effects, especially when taken in high doses or over extended periods. One of the primary concerns is its impact on insulin sensitivity. MK-677 can lead to decreased insulin sensitivity, which may increase the risk of developing type 2 diabetes. This is a critical consideration for individuals with pre-existing insulin resistance or those at risk for diabetes.
Researchers should monitor for any adverse effects during studies involving MK-677.
Another potential side effect is increased blood pressure. Elevated blood pressure can contribute to cardiovascular issues, making it essential to monitor blood pressure levels while using MK-677. Additionally, MK-677 can cause an increase in liver enzymes, which may indicate liver stress or damage. Regular monitoring of liver function is advisable for those using this compound.
It is also important to note that MK-677 is not approved for human use. It is classified as an unapproved drug and is only legally available for research purposes. This means it cannot be used as an ingredient in dietary supplements or commercial products intended for human consumption. Researchers and consumers should exercise caution and ensure they are using MK-677 in compliance with legal regulations.
By understanding the potential risks and legal status of MK-677, researchers can make informed decisions about its use in their studies.
LOOKING FOR WHERE TO BUY MK-677 (IBUTAMOREN) ONLINE
When searching for research peptides online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research.
Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy MK-677 (Ibutamoren) for sale.
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References:
Jeong YO, Shin SJ, Park JY, Ku BK, Song JS, Kim JJ, Jeon SG, Lee SM, Moon M. MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer’s Disease. Int J Mol Sci. 2018 Jun 18;19(6):1800. doi: 10.3390/ijms19061800. PMID: 29912176; PMCID: PMC6032329.
Copinschi G, Van Onderbergen A, L’Hermite-Baleriaux M, et al. 1996 Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men. J Clin. Endocrinol. Metab. 81:2776–2782.
Patchett AA, Nargund RP, Tata JR, et al. 1995 Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue. Proc Natl Acad Sci USA. 92:7001–7005.
