MK-677 is also known as Ibutamoren. This research liquid is a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.

Animal studies also show that ghrelin improves cognitive impairments in several neurological disorders, suggesting that MK-677 might be a potential treatment for the early phase of Alzheimer’s disease.

MK-677 (Ibutamoren) is available in liquid form at 25mg per ml.

At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy MK-677 (Ibutamoren) for sale for research purposes only and not for human consumption.

WHAT IS MK-677 (IBUTAMOREN)?

MK-677 (Ibutamoren) is a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor. 

Research in animals shows it acts like the endogenous hormone ghrelin increasing the secretion of several hormones, including Growth Hormone and insulin-like growth factor 1 (IGF-1). It increases the plasma levels of these hormones without affecting cortisol levels, a very beneficial effect.

MK-677 (Ibutamoren) also reverses diet-induced nitrogen wasting and increases muscle mass, as seen in catabolic animals because of certain acute or chronic diseases.

STRUCTURE OF MK-677 (IBUTAMOREN)

Molecular Formula: C₂₇H₃₆N₄O₅S

Molecular weight: 528.7 g/mol

CAS number: 159634-47-6

IUPAC name: 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide

MECHANISM OF ACTION

Liquid MK-677 (Ibutamoren) mimics the ghrelin hormone released in the walls of the stomach when hungry. Ghrelin binds itself to the growth hormone secretagogue-receptor type 1a (GHS-R1a), which increases appetite. This whole mechanism affects the pituitary and hypothalamus, which play a role in enhancing growth, and burns the fat associated with the thighs, waist, and abdomen in research subjects.

MK-677 (Ibutamoren) is active after oral administration in animals with a half-life of more than twenty (20) hours (almost 24 hours).

MK-677 (IBUTAMOREN) EFFECTS

Based on available research, the benefits of MK-677 (Ibutamoren) may include:

• Strengthening muscle mass, preventing muscle loss
• Fat burning
• It strengthens bones and enhances bone density
• Reverses nitrogen waste
• It enhances sleep

MK-677 (IBUTAMOREN) SIDE EFFECTS

Below are what researchers noticed during clinical trials with MK-677 (Ibutamoren) use in animal test studies.

• water retention and swelling
• reduced insulin sensitivity and increased hunger
• joint and muscle pain
• headaches and migraines
• increased anxiety
• lethargy

LOOKING FOR WHERE TO BUY MK-677 (IBUTAMOREN) ONLINE

When searching for research peptides online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research. 

Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy MK-677 (Ibutamoren) for sale. 

Visit our website or contact us today to buy MK-677 (Ibutamoren) online.

References:

1. Jeong YO, Shin SJ, Park JY, Ku BK, Song JS, Kim JJ, Jeon SG, Lee SM, Moon M. MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer’s Disease. Int J Mol Sci. 2018 Jun 18;19(6):1800. doi: 10.3390/ijms19061800. PMID: 29912176; PMCID: PMC6032329.

2. Copinschi G, Van Onderbergen A, L’Hermite-Baleriaux M, et al. 1996 Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men. J Clin. Endocrinol. Metab. 81:2776–2782.

1.  Patchett AA, Nargund RP, Tata JR, et al. 1995 Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue. Proc Natl Acad Sci USA. 92:7001–7005.