WHAT IS EPITALON ?
21September 21, 2022
What is Epitalon? A Look at Its Anti-Aging Effects and Uses
Epitalon is a synthetic version of the polypeptide Epithalamin naturally produced in the pineal gland in animal test subjects.
It was first discovered in Russia in the 1980s by a scientist, Professor Vladimir Khavinson. He conducted studies on mice and found that epitalon had potential anti-aging properties due to telomerase activation and elongation of telomeres, which may slow down the aging process.
Epitalon is available in lyophilized powder form and sold in 10 mg vials.
At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy epitalon for sale for research purposes only and not for human consumption.
WHAT IS EPITALON?
Epitalon (Epithalon or Epithalone) is a synthetic tetrapeptide consisting of four amino acids (Alanine, Glutamic acid, Aspartic acid, and Glycine). It is identical to the natural peptide called Epithalamin, a hormone produced by the pineal gland in animal test subjects.
It regulates the level of melatonin in the body of research animals, improving the circadian rhythm. It also has anti-aging effects and inhibits the spread of cancer cells in the breasts, colon, prostate, e.t.c. Epitalon is also involved in peptide regulation, influencing various biological processes through its interaction with DNA and histone proteins.
STRUCTURE OF EPITALON AND ITS RELATION TO THE PINEAL GLAND
Molecular Formula: C14H22N4O9
Molecular weight: 390.35g/mol
CAS number: 307297-39-8
IUPAC name: (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
MECHANISM OF ACTION AND TELOMERASE ACTIVITY
Epitalon has been shown in studies to increase the production of telomerase, a natural enzyme that helps human cells reproduce telomeres. This activity is particularly significant in human stem cells, where telomerase activation can enhance cellular longevity and function.
It is the protective component of DNA and prevents the loss of genetic information.
If telomerase is activated, cells can potentially exceed their time limit and may reverse the mechanism of aging.
THE SCIENCE BEHIND EPITALON PEPTIDE
EPITALON EFFECTS ON THE AGING PROCESS
As a result of Epitalon’s effect on telomerase production, its potential benefits include:
Increasing life expectancy
Improving the quality of sleep
Preventing age-related conditions, including dementia, cancer, heart disease, e.t.c.
May act as an antioxidant
Improving skin health and appearance
Accelerating wound healing
Boosts energy and reduces stress
In cell culture studies, Epitalon has been shown to influence gene expression levels in various cell types.
These effects have been observed in different cell cultures, including human gingival mesenchymal stem cells (hGMSCs).
Research on gingival mesenchymal stem cells (hGMSCs) has shown that Epitalon can upregulate neurogenic differentiation markers.
Additionally, Epitalon has been found to influence neuronal differentiation gene expression, enhancing the differentiation of stem cells into neuronal cells.
OPTIMAL EPITALON DOSAGE FOR ANTI-AGING BENEFITS
Determining the right Epitalon dosage is crucial for achieving effective anti-aging benefits. Research suggests that a range of dosages can influence the peptide’s efficacy in extending telomere length and enhancing overall health. Factors such as individual health status, age, and specific goals play a significant role in determining the appropriate Epitalon dose.
Subcutaneous injections are a common method of administration, allowing the peptide to be absorbed directly into the bloodstream. The frequency of administration also impacts its effectiveness, with protocols often recommending a course of treatment over a specified period. Typically, the optimal dosage of Epitalon for anti-aging benefits ranges from 5-10 mg per day. However, this may vary depending on individual factors, and it is essential to consult with a healthcare professional before starting Epitalon therapy.
Epitalon’s effects on telomerase activity and telomere elongation are dose-dependent, with higher doses leading to more significant increases in telomerase activity. The peptide’s ability to stimulate gene expression and protein synthesis in human somatic cells is also dose-dependent. Further research is needed to determine the optimal dosage of Epitalon for specific anti-aging benefits.
EPITALON SIDE EFFECTS AND CANCER PREVENTION
An interesting note about epitalon is that there are hardly any reported side effects in clinical or experimental trials.
However, one of the most astounding side effects researchers noticed is that the animal test subjects live longer than those not exposed to Epitalon. Some test subjects have decreased mortality rates compared to their counterparts exposed to placebos.
FORMS OF EPITALON AVAILABLE
Epitalon is available in several forms, with subcutaneous injection being the most common method of administration. This ensures optimal absorption and bioavailability of the peptide. While Epitalon is also available in oral form, its bioavailability and efficacy may be lower compared to subcutaneous injection.
The peptide can be administered in various dosages and frequencies, tailored to individual needs and goals. Epitalon is available in different molecular forms, each with unique properties and potential applications. Despite these variations, the amino acid sequence of Epitalon, Ala-Glu-Asp-Gly, remains consistent across all forms, ensuring its effects on telomerase activity and telomere elongation.
The availability of Epitalon in different forms allows for flexibility in treatment protocols and individualized approaches to anti-aging therapy. The peptide’s forms and dosages can be customized to address specific needs, such as cancer prevention or general anti-aging benefits. Further research is needed to determine the optimal form and dosage of Epitalon for specific applications, but its availability in various forms has significantly expanded its potential uses in the field of anti-aging medicine.
LOOKING FOR WHERE TO BUY EPITALON ONLINE
When searching for research peptides online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research.
Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy Epitalon for sale.
Visit our website or contact us today to buy Epitalon online.
References:
Khavinson V.K. Peptides and aging. Neuroendocrine. Lett. 2002;23:11–144. [PubMed] [Google Scholar]
Khavinson V.K., Linkova N.S., Tarnovskaya S.I. Short Peptides Regulate Gene Expression. Bull. Exp. Biol. Med. 2016;162:288–292. doi: 10.1007/s10517-016-3596-7. [PubMed] [CrossRef] [Google Scholar]
Anisimov V.N., Khavinson V.K. Peptide bioregulation of aging: Results and prospects. Biogerontology. 2010;11:139–149. doi: 10.1007/s10522-009-9249-8. [PubMed] [CrossRef] [Google Scholar]
Khavinson V.K., Bondarev I.E., Butyugov A.A. Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bull. Exp. Biol. Med. 2003;135:590–592. doi: 10.1023/A:1025493705728. [PubMed] [CrossRef] [Google Scholar]
