Liothyronine is a therapeutic formulation of the endogenous thyroid hormone triiodothyronine (or T3). 

It is sold in liquid form in 100mcg per ml vials for research and analytical purposes.

At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy liothyronine for sale for research purposes only and not for human consumption.

WHAT IS LIOTHYRONINE T3 ?

Liothyronine is a synthetic form of the thyroid hormone triiodothyronine (or T3).

T3 is present in various tissues in animal test subjects, such as the hypothalamus, adipose tissue, and skeletal muscles, and has many physiological functions.

PHYSIOLOGIC ROLE OF T3 

• T3 regulates glucose metabolism. 
• It is also associated with the metabolism of cholesterol.
• It plays a role in the adaptation to cold through the T3 receptors-alpha and -beta. 
• T3 also regulates heat production in brown adipose tissue and skeletal muscle.

Liothyronine exerts all the effects of the endogenous thyroid T3 hormone, and in hormonal replacement in animal studies, it proved to be more potent when compared to levothyroxine.

STRUCTURE OF LIOTHYRONINE

Molecular Formula: C₁₅H₁₂I₃NO₄

Molecular weight: 650.97g/mol

CAS number: 15785-49-6

IUPAC name: (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid

MECHANISM OF ACTION

Liothyronine replaces endogenous thyroid hormone and exerts its physiologic effects by controlling DNA transcription and protein synthesis. 

When it binds to the thyroid receptors attached to DNA, it behaves like the endogenous thyroid T3 hormone. Hence, it accelerates cellular oxidation, stimulating growth, maturation, and metabolism of the body tissues.

It aids in the myelination of nerves and develops synaptic processes in the nervous system. It also enhances carbohydrate and protein metabolism based on available animal studies.

The half-life of liothyronine is between 1 and 2 days.

LIOTHYRONINE EFFECTS

Based on the studies conducted on animals, liothyronine may play a role in treating the following:

• Symptoms of obesity
• Fibromyalgia, fatigue, and depressive symptoms
• An underactive thyroid, a condition which is also known as hypothyroidism
• Thyroid cancer and goiter
• Infertility due to low thyroid hormone levels
• Myxedema coma

LIOTHYRONINE SIDE EFFECTS

The side effects of Liothyronine seen in animal test subjects include:

• Weight loss
• Headache
• Stomach cramps, vomiting, and diarrhea
• Anxiety, nervousness, tremors, and irritability
• Insomnia
• Excessive sweating
• Increased appetite
• Fever and heat sensitivity
• Changes in the menstrual cycle
• Arrhythmias and heart failure

LOOKING FOR WHERE TO BUY LIOTHYRONINE ONLINE

When searching for research liquids online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research. 

Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy liothyronine for sale. 

Visit our website or contact us today to buy liothyronine online.

References:

1. Mullur R, Liu YY, Brent GA. Thyroid hormone regulation of metabolism. Physiological reviews. 2014;94(2):355-382.

2. Branco M, Ribeiro M, Negrao N, Bianco AC. 3,5,3′-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity. The American journal of physiology. 1999;276(1 Pt 1): E179-187.

3. Novitzky D, Cooper DK. Thyroid hormone and the stunned myocardium. The journal of endocrinology. 2014;223(1): R1-8.

1. Nagao H, Sasaki M, Imazu T, Takahashi K, Aoki H, Minato K. Effects of triiodothyronine on turnover rate and metabolizing enzymes for thyroxine in thyroidectomized rats. Life sciences. 2014;116(2):74-82.