Anastrozole is a nonsteroidal aromatase inhibitor that effectively blocks estrogen synthesis in postmenopausal animal test subjects.
According to the data obtained through clinical studies on rats, anastrozole treated breast cancer cells by shrinking them, making it a potential antineoplastic agent. It may also inhibit androstenedione-induced uterine hypertrophy in sexually immature rats.
It is sold in liquid form in 1mg per ml vials for research and analytical purposes.
WHAT IS ANASTROZOLE?
Anastrozole is an anti-aromatase hormone that works by blocking estrogen synthesis.
It is a member of the nitrile and triazole families.
Anastrozole is a research liquid used for hormone therapy studies in rats. It shows great potential in managing breast cancer.
STRUCTURE OF ANASTROZOLE
Molecular Formula: C17H19N5
Molecular weight: 293.4g/mol
CAS number: 120511-73-1
IUPAC name: 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
MECHANISM OF ACTION
Anastrozole is a nonsteroidal third-generation aromatase inhibitor. It selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex that interferes with estradiol production in peripheral tissues, including those of the premenopausal ovary, liver, breast, and other fatty tissues.
Because estrogen acts as a growth factor for hormone-dependent breast cancer cells, anastrozole may treat animal test models with breast cancer caused by estrogen.
Anastrozole has a relatively long duration of action, allowing for once-daily dosing. Its elimination half-life is approximately 50 hours.
Anastrozole benefits in animal test subjects include:
- Beneficial as an adjunct therapy for hormone receptor-positive early breast cancer in postmenopausal test subjects.
- The first-line treatment for hormone receptor-positive (or hormone receptor-unknown) locally advanced or metastatic breast cancer.
- Treating peripheral precocious puberty
- Balancing testosterone levels in infertile male animals
ANASTROZOLE SIDE EFFECTS
The side effects of anastrozole seen in animal test subjects include:
- Decrease spine and hip bone mineral density (BMD)
- Hot flashes
- Altered moods like depression
- Arthritis and arthralgia
- Nausea and vomiting
- Peripheral edema
- Upper respiratory symptoms like coughing, dyspnea, and pharyngitis
LOOKING FOR WHERE TO BUY ANASTROZOLE ONLINE
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- Lønning P (2003). “Clinical pharmacokinetics of aromatase inhibitors and inactivators”. Clinical Pharmacokinetics. 42 (7): 619–31. doi:10.2165/00003088-200342070-00002. PMID 12844324. S2CID 9585901.
- Lønning P, Pfister C, Martoni A, Zamagni C (August 2003). “Pharmacokinetics of third-generation aromatase inhibitors”. Seminars in Oncology. 30 (4 Suppl 14): 23–32. doi:10.1016/S0093-7754(03)00305-1. PMID 14513434.
- Sanford M, Plosker GL (2008). “Anastrozole: a review of its use in postmenopausal women with early-stage breast cancer”. Drugs. 68 (9): 1319–40. doi:10.2165/00003495-200868090-00007. PMID 18547136.
- Chemical Entities of Biological Interest (ChEBI). European Molecular Biology Laboratory. Archived from the original on 2011-09-22. Retrieved 2011-08-14.
- “Highlights of Prescribing Information Anastrozole” (PDF). FDA. Retrieved 31 July 2019.
- The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
- Chen S (1998) Aromatase and breast cancer. Front Biosci 3: d922–d933