BPC157: What is it and how does it work?
18August 18, 2022
Understanding BPC157: Properties, Uses, and Research Implications
BPC157 or BPC-157, also known as Body Protection Compound 15 or Bepecin, is a synthetic pentadecapeptide comprising 15 amino acids in its structure.
Laboratory investigations with animal models have demonstrated that BPC157 exhibits notable anti-inflammatory and therapeutic properties that appear to facilitate healing processes across various tissue types, including skin, muscle, bone, ligament, and tendon structures. Alongside BPC157, research into other peptides such as TB-500 continues to explore their potential roles in tissue recovery mechanisms and physiological function in experimental settings.
At Loti Labs, we are committed to providing high-quality research compounds for scientific investigation.
BPC157 is available for research purposes exclusively and is not intended for human consumption. The compound is supplied in lyophilized powder form at a concentration of 5mg per vial to facilitate precise laboratory applications.
WHAT IS BPC157?
BPC157 represents a synthetic pentadecapeptide that research suggests may influence and modulate digestive tract functionality in laboratory animal subjects.
Current scientific literature indicates that this peptide appears to offer protection to the endothelial tissues in animal models and serves as a significant factor in angiogenesis processes, positioning it as a compound of interest for investigations into tissue restoration, regenerative mechanisms following injury, and gastrointestinal system maintenance.
Research suggests that BPC157 may have applications in the study of gastrointestinal conditions such as intestinal epithelial inflammation, eosinophilic esophagitis, and inflammatory bowel disease in laboratory rat models.
STRUCTURE OF BPC-157
Molecular Formula: C62H98N16 O22
Molecular weight:1419.5 g/mol
CAS number: 137525-51-0
IUPAC name: (4S)-4-[(2-aminoacetyl)amino]-5-[(2S)-2-[(2S)-2-[(2S)-2-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[2-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-5-oxopentanoic acid
The mechanism of action studies indicate that BPC157 appears to have an indirect relationship with endothelial nitric oxide (NO) production. Laboratory investigations have demonstrated that BPC157 may stimulate NO generation in in-vitro experiments utilizing rat gastric mucosa samples.
Research examining stomach ulcer models has found that the protective effects of NO precursor, L-arginine, are reversed by N(G)-nitro-L-arginine methyl ester (L-NAME), a compound that inhibits NO production.
However, scientific data suggests that L-NAME may only partially attenuate the effects of BPC157 on various lesions observed in animal test subjects.
MECHANISM OF ACTION AND BIOLOGICAL PATHWAYS
BPC-157’s mechanism of action presents a compelling interplay with diverse biological pathways. This naturally occurring protein-based peptide has been studied for its potential to influence growth factors, collagen formation, and blood vessel development, processes that are fundamental to tissue repair mechanisms in research models. The specific amino acid sequence of BPC-157 appears to interact with several cellular signaling pathways, particularly those involved in angiogenesis, collagen synthesis, and growth factor expression.
A notable characteristic of BPC-157 observed in laboratory settings is its stability in gastric juice, allowing it to maintain biological activity without degradation. This stability makes it particularly interesting for scientific investigation. Research suggests that BPC-157 may accelerate tissue repair processes by influencing the expression of growth factors, especially vascular endothelial growth factor (VEGF). This process appears important for the formation of new blood vessels, potentially ensuring that healing tissues receive optimal blood supply in experimental models. The compound’s influence on blood vessel development represents a significant area of interest in tissue repair and regeneration research.
RESEARCH APPLICATIONS AND POTENTIAL BENEFITS
BPC-157 offers numerous research applications, making it a versatile peptide for scientific investigation. Here are some key areas of research interest:
Tissue Repair Mechanisms: Research suggests BPC-157 may influence tissue repair by affecting growth factor expression and promoting the formation of new blood vessels in laboratory models. This presents interesting avenues for understanding healing processes.
Wound Healing Processes: Studies indicate the peptide might enhance wound healing by potentially increasing collagen formation and promoting angiogenesis. These mechanisms are crucial for effective tissue regeneration in research settings.
Gastrointestinal Investigations: BPC-157 appears to maintain gastric mucosal integrity in animal models by protecting gastric endothelial cells and potentially accelerating the healing of gastric lesions. This makes it a compound of interest for gastrointestinal research.
Musculoskeletal Research: BPC-157 shows potential in musculoskeletal tissue repair studies. Laboratory research demonstrates possible effects on tendons, ligaments, and muscles, making it valuable for sports science and rehabilitation research.
Inflammatory Response Studies: Research suggests BPC-157 exhibits anti-inflammatory properties through its interaction with various inflammatory mediators. This may help advance our understanding of inflammation and tissue recovery in experimental models.
BPC157 EFFECTS ON TISSUE REPAIR
According to controlled animal experimental studies, several interesting effects have been noted when investigating BPC157.
The research findings include:
Potential anti-inflammatory properties in laboratory models.
Influence on angiogenesis and vasculogenesis processes.
Apparent acceleration of wound healing in experimental muscle, ligament, tendon, and nerve models.
Possible enhancement of muscle function in research settings through reduction of inflammatory markers and improvement of blood flow, areas of interest for athletic performance research.
Maintenance of gastrointestinal mucosa integrity in laboratory studies.
Protective effects against experimental gastric ulcers in animal models.
Potential improvement of digestive function in research settings.
Apparent protective effects on liver tissue exposed to various compounds in laboratory conditions.
Potential protective and restorative effects on intestinal epithelium in experimental models.
Research suggests that BPC157 demonstrates anti-inflammatory properties and may accelerate tissue healing in laboratory settings, making it a compound of interest for various research applications.
ADMINISTERING BPC-157 IN RESEARCH SETTINGS
For optimal research outcomes with BPC-157, it is essential to follow appropriate protocols for preparation and administration. The typical research concentration ranges from 200-800 mcg per day, with a standard research protocol suggesting 10 mcg per kilogram of subject weight. In laboratory settings, BPC-157 can be administered via subcutaneous injection or studied for oral administration effects.
When utilizing injections in research protocols, ensuring sterile conditions with proper laboratory equipment is essential before introducing the peptide into the appropriate tissue. For oral administration studies, research suggests that concurrent food intake may influence absorption patterns. It is crucial that all research be conducted under proper laboratory conditions with appropriate oversight and in accordance with research guidelines. This ensures that investigations are carried out with scientific rigor, maximizing the validity of research outcomes.
RESEARCH AND STUDIES ON BPC-157
Scientific investigation into BPC-157 encompasses numerous research areas, including wound healing mechanisms, tissue regeneration processes, vascular repair dynamics, and neuroprotective effects. Laboratory studies have revealed a complex network of molecular interactions through which BPC-157 appears to influence cellular behavior, tissue repair processes, and organ functionality.
Ongoing research aims to further elucidate BPC-157’s effects and provide a comprehensive understanding of its potential applications in scientific contexts. The compound has garnered attention among scientific communicators like Andrew Huberman and Joe Rogan, who have discussed research findings related to tissue repair and regeneration. These discussions have brought scientific interest to BPC-157, highlighting its potential role in understanding healing mechanisms and physiological processes in research settings.
By examining these diverse research areas, the scientific community continues to expand our knowledge of BPC-157 and its potential significance in various fields of study.
LABORATORY OBSERVATIONS
Research observations from animal test subjects administered BPC157 under laboratory conditions are typically minimal when appropriate research protocols are followed.
Some observations noted in research settings include:
Temporary changes in body temperature regulation
Alterations in consumption patterns and body mass measurements
Equilibrium disturbances in some subjects
Reduced activity levels
Cranial discomfort manifestations
RESEARCH SUPPLY INFORMATION
When procuring research peptides for laboratory investigation, it is essential to source materials from established research suppliers to ensure experimental integrity.
Loti Labs provides research compounds with comprehensive quality control documentation at competitive rates.
We offer detailed technical support and a comprehensive return policy for our research compounds.
Visit our website or contact our research department today for more information about BPC157 availability for laboratory applications.
References:
Jelovac N., Sikiric P., Rucman R., Petek M., Marovic A., Perovic D., Seiwerth S., Mise S., Turkovic B., Dodig G., Miklic P., Buljat G., Prkacin I. Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats. J. Pharmacol. 1999;379(1):19–31.
Tkalcević VI, et al. Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression. Eur J Pharmacol. (2007).
Sikirić P, et al. Pentadecapeptide BPC 157 interactions with adrenergic and dopaminergic systems in mucosal protection in stress. Dig Dis Sci. (1997)
Sikiric P, et al. The antidepressant effect of an anti-ulcer pentadecapeptide BPC 157 in Porsolt’s test and chronic unpredictable stress in rats. A comparison with antidepressants. J Physiol Paris. (2000).
Klicek R, et al. Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability. J Physiol Pharmacol. (2013).
