Epitalon Review | Buy Epitalon
21December 21, 2019
Epitalon is a synthetic peptide derived from the amino acid sequence of the naturally occurring peptide Epithalamin. Amino acid analysis plays a crucial role in understanding the structure and functions of Epitalon, which has potential benefits in delaying oocyte aging and inhibiting tumor development. This peptide has been studied for its potential to increase the lifespan of cells and improve overall health.
What is Epitalon?
Epitalon is a synthetic tetrapeptide composed of four amino acids: alanine, glutamic acid, aspartic acid, and glycine. This pineal peptide preparation has garnered significant attention for its potential anti-aging effects and its ability to regulate gene expression and protein synthesis. Derived from epithalamin, a crude polypeptide extracted from the pineal gland, Epitalon was developed in the 1980s by a research team led by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. This groundbreaking discovery has paved the way for extensive research into the peptide’s numerous health benefits.
Epitalon Review | Buy Epitalon
Understanding Epitalon Peptide: Benefits, Mechanism, and Pineal Gland Usage
A Russian scientist by the name Professor Vladimir Khavinson discovered Epitalon and researched it for over 35 years. The results showed that epitalon reverses aging, prevents cancer, aids better sleep to mention but a few. This discovery has sparked significant interest in anti aging research, exploring innovative treatments and compounds like Epitalon. If you are looking for where to buy epitalon, look no further. Loti Labs is a giant in the peptide research industry. Our peptides are exceptionally high-quality and affordable. They are for research purposes only and are not formulated for human consumption.
Epitalon may slow down the aging process by extending telomeres, which could contribute to healthier cell functions and an overall increase in lifespan and vitality.
Understanding Epitalon: Benefits and Mechanism Explained
Epitalon is also known as Epithalon or Epithalamine, a synthetic pineal tetrapeptide because it consists of four amino acids (Alanine, Glutamic acid, Aspartic acid, Glycine). It is identical to the natural peptide called Epithalamin, a hormone produced by the pineal gland.
It plays a role in metabolism, increasing the sensitivity of the hypothalamus to its natural hormone influences regulating the level of melatonin in the body of animal test subjects, which is responsible for improving the circadian rhythm. It also has anti-aging effects and extends life expectancy. It also inhibits the proliferation of cancer cells in the breasts, colon, prostate etc. Epitalon has been extensively researched in cell cultures, highlighting its importance in scientific studies and experiments.
STRUCTURE OF EPITALON AND AMINO ACIDS
Epitalon has shown promising results in various studies. One notable study focused on colon carcinogenesis, where Epitalon significantly reduced the incidence and size of colon tumors in rats exposed to the carcinogen 1,2-dimethylhydrazine, suggesting a potential therapeutic role for this peptide in colon cancer prevention.
Sequence: H-Ala-Glu-Asp-Gly-OH
1422N4O9
Molecular weight: 390.35 g/mol
CAS number: 64082-79-7
Further research on colon carcinogenesis induced by chemical agents has examined the effects of Epitalon on colon cancer in laboratory rats. These studies detail experimental setups, dosage, and variations in tumor development as a function of treatment, emphasizing the relationship between the pineal gland, hormonal factors, and tumor growth.
MECHANISM OF ACTION IN CELLULAR AGING
Epitalon increases the production of telomerase, a natural enzyme that helps cells reproduce telomeres, which are the protective components of DNA and prevent the loss of genetic information resulting in the chromosome-shortening which occurs in cell division. Telomeres get shorter every time a cell divides, and this is closely linked to age-related diseases, such as cardiovascular diseases, and ultimately death in elderly subjects. Additionally, the pineal peptide preparation Epithalamin has been shown to have inhibitory effects on tumor development and carcinogenesis, particularly in studies involving colon cancer in rats.
If telomerase can be activated, cells can potentially exceed their time limit and continue to replicate reversing the mechanism of aging because the longer the telomere strand is, the better cell health and replication they provide. Therefore, Epitalon, along with other pineal peptides, plays a vital role in decreasing the aging process and extends longevity. Research also indicates that Epitalon can reduce spontaneous tumour incidence, thereby lowering cancer risk and potentially increasing lifespan.
EPITALON EFFECTS IN ANTI AGING RESEARCH
Several animal studies have demonstrated several effects of epitalon. These include:
Preventing cancer: Epitalon inhibits the growth of cancer tumors and prevents the development of metastasis by activating melatonin secretion. This can be explained by examining the link between the pineal gland and cancer. Epitalon stimulates the pineal gland to secrete a hormone called melatonin. Studies show there is a converse relationship between melatonin and malignant tumor growth in the breast, colon, prostate, e.t.c.
Enhancing deep sleep: melatonin produced from the stimulation of epitalon on the pineal gland is responsible for deep sleep patterns.
Increasing lifespan: Epitalon reactivates the production of telomerase, which strengthens and elongates telomeres in DNA strands. This decreases cell death and extends lifespan preventing age-related diseases.
Promoting improved skin health
Eliminating free radicals: Epitalon has powerful antioxidant properties. It eliminates oxygen-free radicals responsible for destroying cells, which are the main source of degenerative diseases such as dementia, Alzheimer’s, heart disease, and more.
Improving vision: Epitalon prolongs the functional integrity of the eye retina in rats with hereditary Retinitis Pigmentosa and improves the vision in patients with pigmental retinal degeneration.
Epitalon and Gene Expression
Epitalon has been shown to have a profound impact on gene expression, particularly in relation to the aging process. One of its most notable effects is the upregulation of telomerase activity, an enzyme that helps to lengthen telomeres and promote cellular longevity. By enhancing telomerase activity, Epitalon can potentially slow down the aging process and extend the lifespan of cells. Additionally, Epitalon regulates the expression of genes involved in cell proliferation and differentiation, ensuring that cells maintain their healthy function and continue to replicate effectively.
Anti-Aging Effects of Epitalon
The anti-aging effects of Epitalon have been extensively studied, revealing its potential to reduce the incidence of spontaneous tumors and spontaneous mammary tumors. Research has shown that Epitalon positively influences biomarkers of aging, such as telomere length and oxidative stress levels. Furthermore, Epitalon promotes skin health by encouraging cell proliferation and reducing the appearance of fine lines and wrinkles. These findings suggest that Epitalon could be a valuable tool in the fight against aging, offering a range of benefits from improved cellular function to enhanced skin vitality.
Safety and Side Effects
Epitalon is generally considered to be safe and well-tolerated, with minimal side effects reported in laboratory and animal studies. However, as with any peptide or supplement, it is crucial to consult with a healthcare professional before using Epitalon, especially if you have underlying medical conditions or are taking medications. Additionally, ensuring that you purchase high-quality Epitalon from a reputable source is vital, as the quality of the peptide can significantly impact its safety and efficacy. By taking these precautions, you can maximize the potential benefits of Epitalon while minimizing any risks.
LOOKING FOR WHERE TO BUY PEPTIDES
You can purchase epitalon from Loti Labs. Buy peptides which are USA-made for the integrity of your research. It is tested through HPLC and Mass spectrometry to ensure quality. Epitalon is commonly sold in 10mg vials. It is available in lyophilized powder form.
Khavinson, V.K., Bondarev, I.E. & Butyugov, A.A. Bulletin of Experimental Biology and Medicine (2003) 135: 590. https://doi.org/10.1023/A:1025493705728
Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo. 2006;20(2):253–257.
Anisimov VN, Khavinson VKh, Alimova IN, Semchenko AV, Yashin AI. Epithalon decelerates aging and suppresses the development of breast adenocarcinomas in transgenic her-2/neu mice. Bull Exp Biol Med. 2002;134(2):187–190. doi:10.1023/a:1021104819170
Alimova IN, Bashurin DA, Popovich IG, et al. Vliianie épitalona i vilona na prodolzhitel’nost’ zhizni i razvitie opukholeĭ molochnoĭ zhelezy u samok transgennykh misheĭ erB-2/neu [Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice]. Vopr Onkol. 2002;48(1):57–60.
