IGF DES 1,3 Review | Buy IGF DES (1-3)


IGF DES 1,3 Review | Buy IGF DES (1-3)

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IGF DES 1,3 stands for Insulin-like Growth Factor Desamino 1,3.

Otherwise called somatomedins, it constitutes a group of protein units that have important function to play in mammalian growth. In animals used as test subjects, IGF des 1,3  enhanced the growth inducing ability of their growth hormones.

Extracted from human brain, bovine colostrum, and porcine uterus, IGF DES 1,3 is a prototype of a parent compound called Insulin-like Growth Factor-1 ( IGF-1 ). It differs from the parent compound due to absence of first three amino acids located at its N-terminus, and due to absence of those peptides, it has a lower affinity for Insulin-like Growth Factor Binding Protein ( IGFBP ). Even at that, it played huge roles in cell proliferation and thereby, growth of animal subjects.

In recent years, this prototype compound has attracted public interest due to the overview that it is about ten times more effective than its parent compound. The parent compound, IGF-1 is a protein which enhances Growth Hormone’s ability to proliferate growth.

Although biologic construction of the prototype is still in preliminary phase, positive result from animal subjects like rabbits has indicated it could be successful in humans too.


Lately, there has been huge interest in IGF Des 1,3 following a revelation that it is more able to trigger growth than the parent IGF-1 compound; a growth hormone mediator. This is attributed to the absence of the tripeptide; Gly-Pro-Glu from the N-terminus of IGF des 1,3.

This article aims to quench every ignorance concerning this new prototype compound since it is relatively new and information about it is limited. At the end of this article, you will also find where to buy the product.


Foremost researches conducted on animal subjects revealed that Growth Hormone ( GH ) was not solely responsible for triggering the addition of Sulphate into cartilage, and thereby causing growth spurt. Growth Hormone played its role by acting indirectly through serum factor erstwhile called sulfaction factor but commonly known as somatomedin, or IGF-1.

IGF Des 1,3 is over ten times more able to trigger hypertrophy and excessive growth of cultured cells than IGF-1. However, they share similar mechanism of action by binding to Insulin-like Growth Factor Binding Protein ( IGFBP ) in order to trigger physiological reactions such as cell proliferation at the skeletal muscle, cartilage, bone, skin and hematopoietic cells. It is also able to control DNA manufacture.

This compound acts as an endocrine growth factor with anabolic effect on far tissues once it is released into the blood tissue.


Being a highly effective growth inducing protein. The compound was recorded to have triggered a net increase in body mass of 15% over a period of four weeks in a young adult mice. However, the high potency reduced in bits when it was applied to animal subjects by in-vitro administration. Even in such case, there was significant cell proliferation in tissues located in the gut. Upon injection of this compound into the muscle tissue of animal samples, it triggered an increase in size and strength of experimental animals.

Certain side effects were observed after administering the compound to young male rats. They include stiffness of both fore limbs and hind limbs, reversed testicular atrophy in males with withered testicles, fatigue, hypoglycaemia in animal samples.


For further research or experiments, IGF DES 1,3 can be purchased online at Loti Labs. They have the compound with purity that is higher than the recommended 95.0%. IGF DES 1,3 is sold in lyophilized powder form in 1mg vials.

Before purchase, the percentage purity is ascertained at the facility by two distinct methods;

(i) Analysis using RP-HPLC ( Reversed-Phase High-Performance Liquid Chromatography ).

(ii) Analysis using SDS-PAGE ( Sodium Dodecyl Sulphate-Polyacrylamide Gel Electrophoresis ).

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