IGF DES 1,3 Review | Buy IGF DES (1-3)
IGF DES 1,3 stands for Insulin-like Growth Factor Desamino 1,3.
Otherwise called somatomedins, it constitutes a group of protein units that have important function to play in mammalian growth. In animals used as test subjects, IGF des 1,3 enhanced the growth inducing ability of their growth hormones.
To maintain stability and prevent degradation during storage and reconstitution, it is recommended to add a carrier protein such as HSA or BSA.
Extracted from human brain, bovine colostrum, and porcine uterus, IGF DES 1,3 is a prototype of a parent compound called Insulin-like Growth Factor-1 ( IGF-1 ). It differs from the parent compound due to absence of first three amino acids located at its N-terminus, and due to absence of those peptides, it has a lower affinity for Insulin-like Growth Factor Binding Protein ( IGFBP ). Even at that, it played huge roles in cell proliferation and thereby, growth of animal subjects.
It is also crucial to prevent freeze-thaw cycles during storage to preserve the biological activity and efficacy of IGF DES 1,3.
In recent years, this prototype compound has attracted public interest due to the overview that it is about ten times more effective than its parent compound. The parent compound, IGF-1 is a protein which enhances Growth Hormone’s ability to proliferate growth.
Although biologic construction of the prototype is still in preliminary phase, positive result from animal subjects like rabbits has indicated it could be successful in humans too.
What is IGF-1?
IGF-1, or Insulin-like Growth Factor 1, is a pivotal protein that plays a crucial role in cell growth, differentiation, and survival. This insulin like growth factor is a key regulator of cell proliferation and is involved in various physiological processes, including muscle growth, bone development, and neuronal function. Produced primarily in the liver, IGF-1 is also expressed in other tissues such as the brain, muscle, and bone. Its widespread presence underscores its importance in maintaining and regulating growth and development throughout the body.
Comprehensive Review of Insulin Like Growth Factor DES 1,3: Benefits and Insights
Lately, there has been huge interest in IGF Des 1,3 following a revelation that it is more able to trigger growth than the parent IGF-1 compound; a growth hormone mediator. This is attributed to the absence of the tripeptide; Gly-Pro-Glu from the N-terminus of IGF des 1,3. IGF DES 1,3 is a human recombinant protein produced using advanced biotechnological methods.
This article aims to quench every ignorance concerning this new prototype compound since it is relatively new and information about it is limited. At the end of this article, you will also find where to buy the product. The purification of IGF DES 1,3 involves proprietary chromatographic techniques to ensure high purity and bioactivity.
Structure and Function of Growth Factor 1 DES
Growth Factor 1 DES, also known as IGF-1 DES, is a truncated version of IGF-1 that lacks the tripeptide Gly-Pro-Glu from the N-terminus end of the protein. This structural modification significantly enhances its potency in stimulating cell proliferation and hypertrophy. Unlike its parent compound, IGF-1 DES exhibits reduced binding to IGF binding proteins (IGFBPs), which increases its bioavailability. This reduced binding allows IGF-1 DES to interact more freely with its receptors, thereby amplifying its growth-promoting effects. The unique structure of IGF-1 DES makes it a powerful agent in promoting cellular growth and development.
IGF DES 1,3 MOA ( MECHANISM OF ACTION ) and IGF Binding Proteins
Foremost researches conducted on animal subjects revealed that Growth Hormone ( GH ) was not solely responsible for triggering the addition of Sulphate into cartilage, and thereby causing growth spurt. Growth Hormone played its role by acting indirectly through serum factor erstwhile called sulfaction factor but commonly known as somatomedin, or IGF-1. Research involving IGF DES 1,3 often utilizes cell culture systems to study its effects on cancer cell differentiation and growth.
IGF Des 1,3 is over ten times more able to trigger hypertrophy and excessive growth of cultured cells than IGF-1. However, they share similar mechanism of action by binding to Insulin-like Growth Factor Binding Protein ( IGFBP ) in order to trigger physiological reactions such as cell proliferation at the skeletal muscle, cartilage, bone, skin and hematopoietic cells. It is also able to control DNA manufacture. The biological activity of IGF DES 1,3 is frequently evaluated using cell proliferation assays, which measure its potency in stimulating cell growth.
This compound acts as an endocrine growth factor with anabolic effect on far tissues once it is released into the blood tissue.
IGF DES 1,3 RESULTS in Cell Proliferation Assay
Being a highly effective growth inducing protein. The compound was recorded to have triggered a net increase in body mass of 15% over a period of four weeks in a young adult mice. However, the high potency reduced in bits when it was applied to animal subjects by in-vitro administration. Even in such case, there was significant cell proliferation in tissues located in the gut. Upon injection of this compound into the muscle tissue of animal samples, it triggered an increase in size and strength of experimental animals. The molecular mass of IGF DES 1,3 is a critical parameter that is carefully measured to ensure consistency and quality.
Certain side effects were observed after administering the compound to young male rats. They include stiffness of both fore limbs and hind limbs, reversed testicular atrophy in males with withered testicles, fatigue, hypoglycaemia in animal samples. IGF DES 1,3 is a human recombinant produced protein, synthesized in E. coli to achieve high purity and biological activity.
Human DES Research and Development
Human DES, also known as IGF-1 DES, has garnered significant attention in recent years due to its potential therapeutic applications. Extensive research has demonstrated that IGF-1 DES can enhance muscle growth and strength, improve bone density, and promote neuronal survival and function. Additionally, IGF-1 DES has shown promising anti-inflammatory and anti-apoptotic effects, making it a potential candidate for treating various conditions such as muscle wasting disorders, osteoporosis, and neurodegenerative diseases. The ongoing research into IGF-1 DES continues to uncover its vast potential in improving human health and treating a range of medical conditions.
WHERE TO BUY IGF DES 1, 3 for Research Purposes
For further research or experiments, IGF DES 1,3 can be purchased online at Loti Labs. They have the compound with purity that is higher than the recommended 95.0%. IGF DES 1,3 is sold in lyophilized powder form in 1mg vials.
It is important to note that IGF DES 1,3 is intended solely for educational and scientific research purposes and is not approved for human consumption.
Before purchase, the percentage purity is ascertained at the facility by two distinct methods;
(i) Analysis using RP-HPLC ( Reversed-Phase High-Performance Liquid Chromatography ).
(ii) Analysis using SDS-PAGE ( Sodium Dodecyl Sulphate-Polyacrylamide Gel Electrophoresis ).
Conclusion
In conclusion, IGF-1 is a crucial protein that plays a key role in cell growth, differentiation, and survival. The truncated version of IGF-1, known as IGF-1 DES, has been shown to be more potent and bioavailable than IGF-1, making it a promising candidate for various therapeutic applications. Further research is needed to fully understand the mechanisms of action of IGF-1 DES and to explore its potential uses in human medicine. The advancements in understanding and utilizing IGF-1 DES could pave the way for new treatments and therapies that harness its powerful growth-promoting properties.
