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{"id":723,"date":"2023-03-09T15:58:00","date_gmt":"2023-03-09T15:58:00","guid":{"rendered":"https:\/\/blog.lotilabs.com\/?p=723"},"modified":"2023-06-11T16:48:11","modified_gmt":"2023-06-11T16:48:11","slug":"review-of-lgd-4033-ligandrol","status":"publish","type":"post","link":"https:\/\/blog.lotilabs.com\/2023\/03\/09\/review-of-lgd-4033-ligandrol\/","title":{"rendered":"Review of LGD-4033 (LIGANDROL)"},"content":{"rendered":"\n

LGD-4033, also known as  Ligandrol, is an investigational selective androgen receptor modulator (SARM) currently being studied for its potential to treat conditions such as muscle wasting and osteoporosis.<\/p>\n\n\n\n

Buy LGD-4033 from Loti Labs, your trusted source for research liquids. It is sold in liquid form in 10 mg per ml vials and is intended as a research chemical, not for human consumption.<\/p>\n\n\n

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\"Buy<\/figure><\/div>\n\n\n

WHAT IS LGD-4033 (LIGANDROL)<\/a><\/h1>\n\n\n\n

LGD-4033 is a novel nonsteroidal, oral SARM that binds to androgen receptors with high affinity and selectivity. <\/p>\n\n\n\n

In animal models, LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and a robust selectivity for muscle versus prostate.<\/p>\n\n\n\n

Unlike anabolic androgenic steroids, selective androgen receptor modulators (SARMs) have tissue-selective activities. They express anabolic effects in the bone and muscle tissues without causing androgenic side effects such as acne and prostate enlargement.<\/p>\n\n\n\n

STRUCTURE OF LGD-4033 (LIGANDROL)<\/h2>\n\n\n
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\"\"\/<\/figure><\/div>\n\n\n

IUPAC Name: 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile<\/p>\n\n\n\n

Molecular Formula: C14<\/sub>H12<\/sub>F6<\/sub>N2<\/sub>O<\/p>\n\n\n\n

Molecular weight: 338.25 g\/mol<\/p>\n\n\n\n

CAS number: 1165910-22-4<\/p>\n\n\n\n

MECHANISM OF ACTION<\/h2>\n\n\n\n

LGD-4033 acts as a ligand that enters the cell by diffusion and attaches to the androgen receptor in the cytoplasm, forming a receptor\/ligand complex that translocates to the nucleus, where it binds the DNA and acts as a transcriptional regulator of androgen-responsive genes.<\/p>\n\n\n\n

It causes dose-dependent suppression of total testosterone, sex hormone\u2013binding globulin, high-density lipoprotein cholesterol, and triglyceride levels after administration. Follicle-stimulating hormone and free testosterone showed significant suppression at 1 mg dose only.<\/p>\n\n\n\n

LGD-4033 has a prolonged elimination half-life (24\u201336 hours).<\/p>\n\n\n\n

LGD-4033 (LIGANDROL) EFFECTS<\/h1>\n\n\n\n

LGD-4033 benefits include:<\/p>\n\n\n\n