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{"id":718,"date":"2023-02-28T15:42:00","date_gmt":"2023-02-28T15:42:00","guid":{"rendered":"https:\/\/blog.lotilabs.com\/?p=718"},"modified":"2023-06-11T15:49:20","modified_gmt":"2023-06-11T15:49:20","slug":"what-is-dutasteride","status":"publish","type":"post","link":"https:\/\/blog.lotilabs.com\/2023\/02\/28\/what-is-dutasteride\/","title":{"rendered":"WHAT IS DUTASTERIDE?"},"content":{"rendered":"\n

Dutasteride is a 5-alpha reductase inhibitor used in treating symptomatic benign prostatic hypertrophy.<\/p>\n\n\n\n

Buy Dutasteride from Loti Labs, your trusted source for research liquids. It is sold in liquid form in mg per ml vials and is intended as a research chemical, not for human consumption.<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

WHAT IS DUTASTERIDE?<\/a><\/h1>\n\n\n\n

Dutasteride is a synthetic 4-azasteroid compound. It reduces the levels of circulating 5-alpha-dihydrotestosterone (DHT). It was also shown to reduce the size of the prostate gland, and improve urinary flow, and symptoms of benign prostatic hyperplasia alone or in combination with tamsulosin. <\/p>\n\n\n\n

The reduction in DHT activity may prevent enlargement of the prostate gland.<\/p>\n\n\n\n

STRUCTURE OF DUTASTERIDE<\/h2>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Molecular Formula: C27<\/sub>H30<\/sub>F6<\/sub>N2<\/sub>O2<\/sub><\/p>\n\n\n\n

Molecular weight: 528.5 g\/mol<\/p>\n\n\n\n

CAS number: 164656-23-9<\/p>\n\n\n\n

IUPAC name: (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide<\/p>\n\n\n\n

MECHANISM OF ACTION<\/h2>\n\n\n\n

As evident from the clinical studies, Dutasteride competitively and specifically binds to type 1 and 2 isoenzymes of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT). It may also cause decreases in serum PSA in the presence of prostate cancer.<\/p>\n\n\n\n

The type 1 isoenzyme is active in the skin and the liver, while type 2 5 alpha-reductase isoenzyme is active in the reproductive tissues.<\/p>\n\n\n\n

The effect of the reduction of DHT by Dutasteride is dose-dependent, with the maximum effect observed within 1-2 weeks following initial administration.<\/p>\n\n\n\n

DUTASTERIDE EFFECTS<\/h1>\n\n\n\n

Dutasteride’s benefits include the management of following conditions:<\/p>\n\n\n\n