Growth hormone-releasing peptides GHRPs are\nsynthetic, non-natural peptides equipped with potent stimulatory effects on\nGrowth hormone secretion in animal test subjects. They have no structural\nresemblance with Growth Hormone-Releasing Hormone and act through specific\nreceptors present either at the pituitary or hypothalamic level in animals. The\nGH-releasing activity of GHRPs is noticeable and dose-related after intravenous\nsubcutaneous intranasal and oral administration.<\/p>\n\n\n\n

The Growth Hormone Releasing Peptides are\naffected by glucose, free fatty acids, glucocorticoids, and somatostatin.<\/p>\n\n\n\n

Ipamorelin is a third-generation GHRP after\nGHRP-6, which belongs to the first generation to be extensively studied in\nanimals. It is similar to GHRP-6 because they both release GH at similar rates\nwithout the side effects that GHRP-6 exhibits. GHRP-6 causes a release, and an\nincrease in cortisol and prolactin levels, however, ipamorelin only selectively\nreleases GH.<\/p>\n\n\n\n

STRUCTURAL DIFFERENCES BETWEEN GHRP6 AND IPAMORELIN<\/h2>\n\n\n\n

\n DIFFERENCES\n <\/td>	\n GHRP 6\n <\/td>	\n IPAMORELIN\n <\/td><\/tr>
\n STRUCTURE\n <\/td>	<\/td>	<\/td><\/tr>
\n AMINO ACID SEQUENCE\n <\/td>	\n His-D-Trp-Ala-Trp-D-Phe-Lys-NH2\n <\/td>	\n H-Aib-His-D-2Nal-D-Phe-Lys-NH2\n <\/td><\/tr>
\n MOLECULAR FORMULA\n <\/td>	\n C46<\/sub>H56<\/sub>N12<\/sub>O6<\/sub>\n <\/td>	\n C38<\/sub>H49<\/sub>N9<\/sub>O5<\/sub>\n <\/td><\/tr>
\n MOLECULAR WEIGHT\n <\/td>	\n 873 g\/mol\n <\/td>	\n 711.9 g\/mol\n <\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n MECHANISM OF ACTION<\/h2>\n\n\n\n Studies in animal test subjects show that both\nGHRP-6 and ipamorelin stimulate Ghrelin, \u201cthe hunger hormone\u201d through its\nghrelin receptor which in turn signal an increased production of growth hormone\n(GH) by acting at the level of the pituitary or hypothalamus through a specific\nreceptor different from that of the endogenous Growth Hormone-Releasing Hormone\nGHRH. The effects of GHRP-6 on GH release were achieved using various doses and\nadministration routes.<\/p>\n\n\n\n \u0406n \u0441\u043entr\u0430\u0455t t\u043e GHRP-6, I\u0440\u0430m\u043er\u0435l\u0456n \u0456\u0455 m\u043er\u0435\n\u0455\u0435l\u0435\u0441t\u0456v\u0435 \u0456n \u0456t\u0455 \u0430\u0441t\u0456v\u0430t\u0456\u043en because it doesn\u2019t have any effect on cortisol or\nprolactin. It \u0456\u0455 m\u0435t\u0430b\u043el\u0456z\u0435d \u0455l\u043ew\u0435r th\u0430n GHRP-6, m\u0430k\u0456ng \u0456t m\u043er\u0435 \u0455t\u0430bl\u0435 \u0430nd\nth\u0435r\u0435b\u0443 \u0435ff\u0435\u0441t\u0456v\u0435 f\u043er l\u043eng\u0435r.<\/p>\n\n\n\n COMPARING AND CONTRASTING THE\nEFFECTS OF IPAMORELIN AND GHRP-6<\/h1>\n\n\n\n Ipamorelin and GHRP-6 have similar effects on\nanimal test subjects but differ structurally. They both act on the pituitary\ngland to release growth hormone. Their differences are listed in the table\nbelow.<\/p>\n\n\n\n \n  \n <\/td> \n GHRP-6\n <\/td> \n IPAMORELIN\n <\/td><\/tr> \n Effect on hunger\n <\/td> \n Increases hunger markedly\n <\/td> \n Doesn\u2019t promote hunger\n <\/td><\/tr> \n Effect on growth hormone release\n <\/td> \n More \n <\/td> \n Less \n <\/td><\/tr> \n Effect on prolactin and cortisol release\n <\/td> \n Less control\n <\/td> \n None observed\n <\/td><\/tr> \n Potency \n <\/td> \n Same\n <\/td> \n Same\n <\/td><\/tr> \n Half-life\n <\/td> \n Shorter half-life\n <\/td> \n Longer half-life\n <\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n CONCLUSION<\/h1>\n\n\n\n GHRP-6 is one of the first GHRPs synthesized,\nand is widely considered to be the most effective of the growth\nhormone-releasing peptides, but the choice between GHRP-6 and ipamorelin\ndepends on the outcome you want to achieve. Whatever your choice is, Loti Labs\nassures you of the highest quality USA-made peptides.<\/p>\n\n\n\n LOOKING FOR WHERE TO BUY PEPTIDES<\/a><\/h1>\n\n\n\n Ipamorelin and GHRP-6 can both be purchased\nfrom Loti Labs. It is important to buy peptides that are USA-made for the\nintegrity of your research. Ipamorelin and GHRP-6 sold from Loti Labs are\ntested through HPLC and Mass spectrometry to ensure quality. Ipamorelin and\nGHRP-6 are available in lyophilized powder form in 2mg and 5mg vials,\nrespectively. Buy your peptides from is today!<\/p>\n\n\n\n References:<\/p>\n\n\n\n Camanni,\n Franco & Ghigo, Ezio & Arvat, Emanuela. (1998). Growth\n Hormone-Releasing Peptides and Their Analogs. Frontiers in\n neuroendocrinology. 19. 47-72. 10.1006\/frne.1997.0158.<\/li><\/ol>\n\n\n\n Wu D, Chen\n C, Zhang J, Bowers CY, Clarke IJ. The effects of GH-releasing peptide-6\n (GHRP-6) and GHRP-2 on intracellular adenosine 3′,5′-monophosphate (cAMP)\n levels and GH secretion in ovine and rat somatotrophs. J Endocrinol.\n 1996;148(2):197\u2013205. doi:10.1677\/joe.0.1480197<\/li><\/ol>\n\n\n\n Rog\u00e9rio G.\n Gondo, Manuel H. Aguiar-Oliveira, C\u00e9sar Y. Hayashida, Sergio P. A.\n Toledo, Neusa Abelin, Michael A. Levine, Cyril Y. Bowers, Anita H. O.\n Souza, Rossana M. C. Pereira, Norma L. Santos, Roberto Salvatori, Growth\n Hormone-Releasing Peptide-2 Stimulates GH Secretion in GH-Deficient\n Patients with Mutated GH-Releasing Hormone Receptor, The Journal of\n Clinical Endocrinology & Metabolism, Volume 86, Issue 7, 1 July 2001,\n Pages 3279\u20133283, https:\/\/doi.org\/10.1210\/jcem.86.7.7694<\/a><\/li><\/ol>\n\n\n\n Raun K,\n Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth\n hormone secretagogue. Eur J Endocrinol. 1998;139(5):552\u2013561.\n doi:10.1530\/eje.0.1390552<\/li><\/ol>\n\n\n\n Johansen PB,\n Nowak J, Skjaerbaek C, et al. Ipamorelin, a new growth-hormone-releasing\n peptide, induces longitudinal bone growth in rats. Growth Horm IGF Res.\n 1999;9(2):106\u2013113. doi:10.1054\/ghir.1999.9998<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":" Please Read our Disclaimer In this article, we will review the growth hormone-releasing peptides ipamorelin and GHRP-6. They have many similarities and a few differences. We aim to help you decide which peptide you need for your research. They are both available for sale at Loti Labs, which is a USA based peptide and research […]<\/p>\n","protected":false},"author":2,"featured_media":370,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"footnotes":""},"categories":[2],"tags":[63,46,405,407,406,404],"aioseo_notices":[],"featured_image_src":{"landsacpe":["https:\/\/blog.lotilabs.com\/wp-content\/uploads\/2020\/01\/post-slider.jpg",960,400,false],"list":["https:\/\/blog.lotilabs.com\/wp-content\/uploads\/2020\/01\/post-slider-463x348.jpg",463,348,true],"medium":["https:\/\/blog.lotilabs.com\/wp-content\/uploads\/2020\/01\/post-slider-300x125.jpg",300,125,true],"full":["https:\/\/blog.lotilabs.com\/wp-content\/uploads\/2020\/01\/post-slider.jpg",960,400,false]},"_links":{"self":[{"href":"https:\/\/blog.lotilabs.com\/wp-json\/wp\/v2\/posts\/501"}],"collection":[{"href":"https:\/\/blog.lotilabs.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.lotilabs.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.lotilabs.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.lotilabs.com\/wp-json\/wp\/v2\/comments?post=501"}],"version-history":[{"count":2,"href":"https:\/\/blog.lotilabs.com\/wp-json\/wp\/v2\/posts\/501\/revisions"}],"predecessor-version":[{"id":519,"href":"https:\/\/blog.lotilabs.com\/wp-json\/wp\/v2\/posts\/501\/revisions\/519"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.lotilabs.com\/wp-json\/wp\/v2\/media\/370"}],"wp:attachment":[{"href":"https:\/\/blog.lotilabs.com\/wp-json\/wp\/v2\/media?parent=501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.lotilabs.com\/wp-json\/wp\/v2\/categories?post=501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.lotilabs.com\/wp-json\/wp\/v2\/tags?post=501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}