Unlocking CJC1295: Benefits for Research Revealed
CJC-1295 without DAC is synthetic analog of Growth Hormone Releasing Factor (GRF) also known as Growth Hormone Releasing Hormone (GHRH). It is a Growth Hormone Secretagogue (GHS) which means it stimulates the secretion of growth hormone.
CJC-1295 no DAC on the other hand is composed of 30 amino acid chains with a molecular weight of 3,3367.2g/mol. Its main mechanism of action mimics the action of GRF/GHRH and stimulate the production of GH. Due to its ability to conjugate or bind with albumin, it counteracts the proteolytic effect of Dipeptidyl Amino Peptidase-IV (DPP-IV) and has an extended half life, allowing for prolonged presence in the bloodstream.
What is CJC-1295 without DAC?
CJC-1295 without DAC is a synthetic peptide designed to mimic the action of Growth Hormone-Releasing Hormone (GHRH). This peptide stimulates the release of growth hormone from the pituitary gland, leading to increased growth hormone levels in the human body. Unlike its natural counterpart, CJC-1295 without DAC is a modified version of GRF 1-29, incorporating specific amino acid substitutions that enhance its stability and effectiveness. Typically available as a lyophilized powder, CJC-1295 without DAC requires reconstitution before use, making it a versatile tool for scientific research focused on growth hormone dynamics.
Understanding Modified Growth Hormone Releasing Factor 1-29: Benefits and Research Insights
Growth Hormone Releasing Hormone (GHRH) or GRF has a total of 44 amino acid chain in its structure, however, studies have confirmed that the first 29 amino acids have the same activity and effect as that of the full chain. This fragment has been known as GRF 1-29.
The main problem with GRF1-29 is its very fast half-life, which lasts only for less than seven minutes. This is due to the proteolytic action of the DPP-IV enzyme. Aside from that, DPP-IV is also involved in other biological processes like apoptosis or programmed cell death, signal transduction, and immune system regulation.
A number of modified GRF1-29 has been developed recently but animal testing in pigs and rats have shown that CJC-1295 is the most stable in stimulating the release of GH. This is why CJC-1295 without dac is also referred to as modified GRF1-29
CJC-1295 without DAC and GHRP/Ipamorelin: Stimulating Growth Hormone Release
CJC-1295 is often combined with Drug Affinity Complex (DAC) and other growth hormone secretagogues such as Growth Hormone Releasing Peptides (GHRP) which includes GHRP-2, GHRP-6, and Ipamorelin.
The difference between these combinations to that with CJC-1295 without DAC and GHRP or Ipamorelin is the increase in GH release and very long half-life.
Mechanism of Action and Growth Hormone Release
CJC-1295 without DAC operates by binding to GHRH receptors located in the anterior pituitary gland. This binding action stimulates the release of growth hormone, resulting in elevated growth hormone levels. The increase in growth hormone can lead to various physiological benefits, including muscle growth, fat loss, and improved recovery times. While the mechanism of action of CJC-1295 without DAC mirrors that of natural GHRH, it has a shorter half-life, necessitating more frequent dosing to maintain the desired elevated growth hormone levels. This characteristic makes it a valuable peptide for research focused on stimulating growth hormone release.
Effects of CJC-1295 without DAC
Studies and animal experiments have found CJC-1295 without DAC to demonstrate the following effects;
Increase Protein Synthesis. CJC-1295 without DAC’s ability to resist enzyme degradation and stimulate the release of Growth Hormone leads to a cascade of processes that leads to increase protein synthesis in animal test subjects.
Decrease Adipose Tissue. Adipose tissue or fat are broken down in a process known as lipolysis. CJC 1295 without DAC has shown to accelerate this process thus its ability to decrease body fat.
Accelerate Wound Healing. The process of wound healing involves several steps and involves a number of proteins. The ability of CJC-1295 without DAC to increase protein synthesis help in this process. Rats given CJC-1295 have shown faster wound healing time compared to those that didn’t receive any.
Higher Bone Density. CJC-1295 without DAC through animal testing has demonstrated to increase bone mineral matter per square inch. It also contributed to the decrease in possibility of fractures, breaks, and other bone related issues.
Scientific Research Applications
CJC-1295 without DAC holds significant potential for scientific research across various fields. Researchers can explore its effects on muscle growth, fat loss, and recovery, providing insights into the role of growth hormone in these processes. Additionally, CJC-1295 without DAC can be used to study the impact of growth hormone on muscle protein synthesis, bone density, and other physiological processes. Its potential therapeutic benefits in conditions such as growth hormone deficiency and muscle wasting diseases also make it a promising candidate for further investigation. By understanding how CJC-1295 without DAC influences various physiological processes, scientists can unlock new avenues for treatment and therapy.
Where to Buy and Handle CJC-1295 for Research
When purchasing CJC-1295 without DAC for research purposes, it is crucial to select a reputable supplier that guarantees high-quality products. Look for suppliers that clearly state the product is for research use only and provide detailed product descriptions. Proper storage and handling are essential to maintain the stability and effectiveness of CJC-1295 without DAC. For short-term use, store the lyophilized powder at room temperature. For long-term storage, keep it at -20°C or -80°C. Once reconstituted, the solution should be stored at 4°C for up to 1-2 weeks or frozen at -20°C for 3-4 months. Adhering to these guidelines ensures the integrity of your research.
Conclusion
CJC-1295 without DAC is a synthetic peptide that effectively mimics the action of GHRH, stimulating the release of growth hormone from the pituitary gland. Its unique mechanism of action and potential research applications make it an invaluable tool for scientists studying growth hormone and its effects on various physiological processes. When purchasing and handling CJC-1295 without DAC, it is essential to choose a reputable supplier and follow proper storage and handling procedures to maintain its stability and effectiveness. By doing so, researchers can ensure the reliability and accuracy of their studies, contributing to the broader understanding of growth hormone dynamics.
Where to Buy CJC-1295
USA-made CJC-1295 can be purchased from Loti Labs. CJC-1295 from Loti Labs are tested through HPLC and Mass Spectrometry to ensure quality, purity, and the integrity of any research or study conducted using it. It is commonly sold in 5mg vials and is available in lyophilized powder form.
References:
Alba, M. et al. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology, Endocrinology and Metabolism.
Jette, L. et al. (2005). hGRF1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: Identification of CJC-1295 as a long lasting GRF analog. Endocrinology.
Benquet, C. et al. (2004). (CJC-1295 (DAC-GRF), a long acting GRF analog, enhances pulsatile GH secretion, increases IGF-I levels, and restores linear growth. Program of the 86th Annual Meeting of the Endocrine Society, New Orleans, LA, p 491 (Abstract P3-109).
