RAD-140: The Controversial SARM Under Scientific Scrutiny

RAD-140, also known as Testolone, has been making waves in the scientific community as a novel selective androgen receptor modulator (SARM). This compound has piqued the interest of researchers due to its potential applications in various fields of medicine13.

What is RAD-140?

RAD-140 is a non-steroidal SARM that selectively binds to androgen receptors in specific tissues6. Its molecular formula is C20H16ClN5O2, with a molecular weight of 393.8 g/mol6. Unlike traditional anabolic steroids, SARMs like RAD-140 are designed to target specific tissues while minimizing effects on others.

Research and Potential Applications

Cancer Research

One area where RAD-140 has shown promise is in cancer research. A first-in-human phase 1 study investigated its potential as a treatment for AR+/ER+/HER2- metastatic breast cancer1. The study aimed to characterize the safety, tolerability, and pharmacokinetic profile of RAD-140.

Neuroprotection

Intriguingly, RAD-140 has also been studied for its potential neuroprotective properties. Research in cultured rat neurons and male rat brains has explored its ability to provide neuroprotection, with findings suggesting it may have relevance to Alzheimer’s disease and related neurodegenerative conditions3.

Controversies and Concerns

Despite the potential benefits, RAD-140 is not without controversy. Recent studies have raised concerns about its long-term effects:

1. Impact on Skeletal Muscle: A study on female mice found that long-term RAD-140 supplementation reduced indices of overall health and failed to improve strength25.
   
2. Health Risks: There have been multiple case studies reporting liver failure in individuals using RAD-1408. This underscores the importance of rigorous scientific research before any potential medical applications.
   

The Future of RAD-140 Research

As with any experimental compound, more research is needed to fully understand RAD-140’s effects, benefits, and potential risks. The scientific community continues to investigate its properties and potential applications, always prioritizing safety and efficacy.

RAD-140 remains a subject of intense scientific interest. As research progresses, we may gain new insights into its potential therapeutic applications and a better understanding of its mechanisms of action.

BUY RAD-140 10mg/ml (30ml)

References:

1. PubMed: A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator
   
2. Wiley Online Library: RAD140 (Testolone) negatively impacts skeletal muscle adaptation
   
3. PMC: Selective Androgen Receptor Modulator RAD140 Is Neuroprotective
   
4. PubChem: Rad-140 Compound Information
   
5. Wiley Online Library: RAD140 (Testolone) study on female mice
   
6. PubChem: Rad-140 Molecular Information
   
7. Sport Integrity Australia: RAD-140 Health Warning
   

Citations:

1. https://pubmed.ncbi.nlm.nih.gov/34565686/
2. https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13824
3. https://pmc.ncbi.nlm.nih.gov/articles/PMC3959610/
4. https://thesarkytype.com/write-an-seo-friendly-blog-that-humans-love-to-read/
5. https://onlinelibrary.wiley.com/doi/10.1111/1440-1681.13824
6. https://pubchem.ncbi.nlm.nih.gov/compound/Rad-140
7. https://www.linkedin.com/posts/sarah-wilson-blackwell_write-an-seo-friendly-blog-thathumans-activity-7225098434255429632-4VIz
8. https://www.sportintegrity.gov.au/news/integrity-blog/2021-05/rad-140-health-warning
9. https://www.jacc.org/doi/10.1016/j.jaccas.2024.102423

Read More:

1. https://blog.lotilabs.com/2025/02/25/mk-677-exploring-the-potential-of-a-promising-growth-hormone-secretagogue/
2. https://blog.lotilabs.com/2025/02/21/gw501516-unveiling-the-potential-of-ppar%ce%b4-agonists-in-metabolic-research/