Tamoxifen Review – Buy Tamoxifen Liquid 20mg per ml (30ml)
25MarMarch 25, 2023
Tamoxifen Review – Buy Tamoxifen Liquid 20mg per ml (30ml)
Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits estradiol binding to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA.
At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy tamoxifen for sale only for research purposes and not for human consumption. It is available in liquid form at 20 mg per ml. As with all prescription compounds, it is important to use Tamoxifen under the guidance of a healthcare provider to ensure safety and efficacy.
Understanding Tamoxifen: Uses, Benefits, and Insights of a Selective Estrogen Receptor Modulator
Tamoxifen is a nonsteroidal antiestrogen, a tertiary amine compound, and a stilbenoid widely used in research for its potential in treating and preventing breast cancer. Research suggests that Tamoxifen functions by binding to estrogen receptors in breast tissue, blocking estrogen’s effects, which is crucial for studying estrogen receptor-positive breast cancer.
Long-term tamoxifen study is associated with fatty liver, steatohepatitis, cirrhosis, and rare cases of clinically apparent acute liver injury. Additionally, research suggests that Tamoxifen is used to reduce the risk of developing breast cancer in high-risk patients by inhibiting the growth of cancer cells that rely on estrogen.
STRUCTURE OF TAMOXIFEN
Molecular formula: C26H29NO
Molecular weight: 371.5 g/mol
CAS number: 10540-29-1
IUPAC name: 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
Understanding the Mechanism of Action of Tamoxifen
Tamoxifen is a selective estrogen receptor modulator that inhibits growth and promotes apoptosis in estrogen receptor-positive tumors.
Data from animal studies suggest that it is absorbed slowly following oral administration, with peak serum concentrations generally occurring about 3-6 hours after a single administration, and its metabolites undergo extensive enterohepatic circulation.
It has a long duration of action as the active metabolite N-desmethyl tamoxifen has a half-life of approximately two weeks. Researchers should be aware that vaginal discharge is a potential observation in studies involving Tamoxifen.
Benefits of Tamoxifen Liquid Form
The liquid form of Tamoxifen Citrate offers several benefits for research purposes, particularly in studies involving subjects with difficulty swallowing pills. This oral liquid formulation provides a precise and manageable method of compound delivery, allowing for flexible administration that can be finely adjusted to meet the individual needs of the study. This is especially advantageous for research involving pediatric and geriatric populations who may find liquid formulations easier to ingest. Additionally, the liquid form of Tamoxifen Citrate can be taken with or without food, making it a convenient option for studies with varying dietary protocols. This flexibility ensures that research can proceed without significant disruptions to experimental routines.
Taking Tamoxifen
When administering Tamoxifen Citrate in research, it is essential to follow the prescribed administration and measurement instructions carefully. The compound should be taken by mouth, using the dropper provided to measure the correct amount accurately. Researchers should avoid mixing the compound with food or drinks without consulting their pharmacist or healthcare provider, as this could affect the compound’s effectiveness. It is also crucial to store the compound at room temperature, away from light and moisture, and to keep it out of reach of children and pets. Adhering to these guidelines helps ensure that the compound remains effective and safe for research use.
TAMOXIFEN EFFECTS ON BREAST CANCER
Research suggests that Tamoxifen benefits include:
Improving blood flow, reducing uterine contractility and pain in dysmenorrhea
Treating early and advanced estrogen receptor-positive (ER-positive or ER+) breast cancer in pre-and postmenopausal females. Additionally, it is the most common hormone treatment for male breast cancer.
Ovulation induction for treating infertility in females with anovulatory disorders.
Improving fertility in males with infertility
Tamoxifen is used to prevent and treat gynecomastia.
For treating peripheral precocious puberty
TAMOXIFEN SIDE EFFECTS INCLUDING BLOOD CLOTS
Tamoxifen has a narrow therapeutic index as higher amounts can lead to many problems. These include:
An increased risk of postmenopausal bleeding, endometrial polyps, hyperplasia, and endometrial cancer
Hair thinning
Hot flashes
Leg cramps
Muscle aches
A rapid increase in triglyceride concentration in the blood
An increased risk of thromboembolism
Hepatotoxicity
Tremor
If you miss a scheduled administration of Tamoxifen, proceed with it as soon as you remember. If it is near the time for your next scheduled administration, skip the missed one and continue with your regular schedule. Do not double up on administrations to compensate for a missed one.
Special Considerations and Precautions
Tamoxifen Citrate should not be used by pregnant or breastfeeding subjects in research studies, as it may pose risks to the fetus or infant. Subjects with a history of blood clots, deep vein thrombosis, or pulmonary embolism should be monitored closely when involved in studies using Tamoxifen Citrate, due to a potential increase in these conditions. Additionally, subjects using birth control substances or other hormonal therapies should have their research protocols discussed with healthcare providers, as these compounds may interact with Tamoxifen Citrate. Subjects with a history of protein kinase C inhibitors or other compounds affecting blood clotting should exercise caution when involved in studies with Tamoxifen Citrate. It is crucial to inform your research supervisor of all compounds and supplements being used to prevent potential interactions and complications.
Clinical Trials and Future Research
Tamoxifen Citrate has been extensively studied in clinical trials, with research suggesting potential efficacy in the study of breast cancer. Ongoing research is focused on exploring the potential benefits of Tamoxifen Citrate in other hormone-related disorders, such as gynecomastia and prostate cancer. Additionally, researchers are investigating the use of Tamoxifen Citrate in combination with other compounds to potentially enhance its effects. As new research emerges, the potential benefits and applications of Tamoxifen Citrate will continue to expand, offering insights for improved research outcomes.
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Tamoxifen is an estrogen antagonist on gonadotropin secretion and responsiveness of the hypothalamic-pituitary-adrenal axis in female monkeys. Endocrine 22, 305-315 [PubMed:14709804]
Sanchez-Spitman AB, Swen JJ, Dezentje VO, Moes DJ, Gelderblom H, Guchelaar HJ (June 2019). “Clinical pharmacokinetics and pharmacogenetics of tamoxifen and endoxifen”. Expert Review of Clinical Pharmacology. 12 (6): 523–536. doi:10.1080/17512433.2019.1610390. PMID 31008668.
“NCI Drug Dictionary”. 2 February 2011. Archived from the original on 8 December 2015. Retrieved 12 September 2021.
Klein DJ, Thorn CF, Desta Z, Flockhart DA, Altman RB, Klein TE (November 2013). “PharmGKB summary: tamoxifen pathway, pharmacokinetics”. Pharmacogenetics and Genomics. 23 (11): 643–647. doi:10.1097/FPC.0b013e3283656bc1. PMC 4084801. PMID 23962908.
Conclusion
Tamoxifen Citrate is a nonsteroidal selective estrogen receptor modulator (SERM) extensively utilized in research for its potential role in examining breast cancer.The liquid form of Tamoxifen Citrate offers several benefits, including flexible administration and ease of use. However, researchers should be aware of the precautions associated with Tamoxifen Citrate, including the potential for blood clots, deep vein thrombosis, and pulmonary embolism. By following the prescribed administration instructions carefully and discussing any concerns with their research supervisor, researchers can maximize the potential insights of Tamoxifen Citrate while minimizing risks. As research continues to uncover the potential applications of Tamoxifen Citrate, this compound will remain a valuable tool in the study of breast cancer and other hormone-related disorders.
