WHAT IS DUTASTERIDE?
Dutasteride is a 5-alpha reductase inhibitor used in treating symptomatic benign prostatic hypertrophy.
Buy Dutasteride from Loti Labs, your trusted source for research liquids. It is sold in liquid form in mg per ml vials and is intended as a research chemical, not for human consumption.
WHAT IS DUTASTERIDE?
Dutasteride is a synthetic 4-azasteroid compound. It reduces the levels of circulating 5-alpha-dihydrotestosterone (DHT). It was also shown to reduce the size of the prostate gland, and improve urinary flow, and symptoms of benign prostatic hyperplasia alone or in combination with tamsulosin.
The reduction in DHT activity may prevent enlargement of the prostate gland.
STRUCTURE OF DUTASTERIDE
Molecular Formula: C27H30F6N2O2
Molecular weight: 528.5 g/mol
CAS number: 164656-23-9
IUPAC name: (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
MECHANISM OF ACTION
As evident from the clinical studies, Dutasteride competitively and specifically binds to type 1 and 2 isoenzymes of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT). It may also cause decreases in serum PSA in the presence of prostate cancer.
The type 1 isoenzyme is active in the skin and the liver, while type 2 5 alpha-reductase isoenzyme is active in the reproductive tissues.
The effect of the reduction of DHT by Dutasteride is dose-dependent, with the maximum effect observed within 1-2 weeks following initial administration.
DUTASTERIDE EFFECTS
Dutasteride’s benefits include the management of following conditions:
- Benign prostatic hyperplasia
- Prostate cancer
- Scalp hair loss
- Transgender hormone therapy
DUTASTERIDE SIDE EFFECTS
Some reported adverse effects from the use of dutasteride are:
- Sexual dysfunction
- Depression
- Impotence
- Reduced libido
- Gynaecomastia
- Ejaculation disorder
- Headache
- Gastrointestinal discomfort
- Menstrual changes
- Acne
- Dizziness
LOOKING FOR WHERE TO BUY DUTASTERIDE ONLINE
When searching for research liquids online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research.
Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy dutasteride for sale.
Visit our website or contact us today to buy dutasteride online.
References:
- Keam SJ, Scott LJ: Dutasteride: a review of its use in the management of prostate disorders. Drugs. 2008;68(4):463-85. [PMID:18318566]
- Shah SK, Trump DL, Sartor O, Tan W, Wilding GE, Mohler JL: Phase II study of Dutasteride for recurrent prostate cancer during androgen deprivation therapy. J Urol. 2009 Feb;181(2):621-6. doi: 10.1016/j.juro.2008.10.014. Epub 2008 Dec 16. [PMID:19091347]
- Arif T, Dorjay K, Adil M, Sami M: Dutasteride in Androgenetic Alopecia: An Update. Curr Clin Pharmacol. 2017;12(1):31-35. doi: 10.2174/1574884712666170310111125. [PMID:28294070]
- Shanshanwal SJ, Dhurat RS: Superiority of dutasteride over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: A randomized controlled open-label, evaluator-blinded study. Indian J Dermatol Venereol Leprol. 2017 Jan-Feb;83(1):47-54. doi: 10.4103/0378-6323.188652. [PMID:27549867]
- Evans HC, Goa KL: Dutasteride. Drugs Aging. 2003;20(12):905-16; discussion 917-8. doi: 10.2165/00002512-200320120-00005. [PMID:14565784]
