Review Of BPC 157 | Buy BPC-157 Peptide Online
20February 20, 2023
BPC-157 is a synthetic peptide that has gained attention for its potential healing properties. It is believed to promote tissue repair, reduce inflammation, and accelerate the healing of injuries. However, it is important to note that BPC-157 is classified as a prohibited substance by the US Anti-Doping Agency (USADA) and the World Anti-Doping Agency (WADA). Professional athletes risk disqualification if found with this substance in their system.
What is BPC-157?
BPC-157, also known as Body Protection Compound 157, is a synthetic peptide derived from a protein found in human gastric juice. This stable gastric pentadecapeptide is renowned for its non-toxic and cytoprotective properties. Extensively studied for its potential therapeutic applications, BPC-157 has shown promise in wound healing, tissue repair, and musculoskeletal soft tissue healing. Its ability to promote rapid recovery in various tissues makes it a valuable compound in the realm of regenerative medicine.
Review Of BPC 157 | Buy BPC-157 Peptide Online
BPC-157, also known as Body Protection Compound 15 or Bepecin, is a synthetic pentadecapeptide consisting of 15 amino acids Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val.
In animal trials, BPC-157 possessed noticeable anti-inflammatory and therapeutic effects to promote the healing of different tissues, including skin, muscle, bone, ligament, and tendon. The beneficial effect of BPC-157 on these tissue injuries includes accelerating healing processes, mediating cytoprotection, and maintaining endothelial integrity. Additionally, BPC-157 influences the formation and preservation of blood vessels, highlighting its role in angiogenesis and its impact on vascular health.
Buy BPC-157 from Loti Labs, your trusted source for research peptides. It is sold in lyophilized powder form at a concentration of 5 mg per vial and is intended as a research chemical, not for human consumption.
[Understanding BPC-157: Benefits, Uses, and Research Insights in Wound Healing](https://blog.lotilabs.com/2019/11/30/what-is-bpc-157-peptide/)
BPC157 is a synthetic pentadecapeptide that regulates and controls how the digestive tract of animal test subjects operates.
Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon. BPC-157 has also been shown to mitigate the adverse effects of chronic alcohol consumption on liver and gastrointestinal health.
BPC-157 also plays a role in new blood vessel formation from pre-existing blood cells, known as angiogenesis.
STRUCTURE OF BPC-157 AND VASCULAR ENDOTHELIAL GROWTH FACTOR
629816 22
Molecular weight:1419.5 g/mol
CAS number: 137525-51-0
IUPAC name: glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolyl-glycyl-L-lysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanyl-glycyl-L-leucyl-L-valine
BPC-157 promotes proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) through the extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling pathway. Unlike traditional growth factors, which often require complex delivery systems and degrade rapidly in the gastrointestinal environment, BPC-157 is stable and effective without additional carriers.
Additionally, BPC-157 enhances growth hormone receptor expression, promoting tendon healing and improving cellular functions in fibrotic environments.
Mechanism of Action
BPC-157 operates through a multifaceted mechanism of action. It interacts with the nitric oxide (NO) system, counteracting the harmful effects of NG-nitro-L-arginine methyl ester (L-NAME). Additionally, BPC-157 stimulates vascular endothelial growth factor (VEGF) receptors, which can induce the expression of cyclooxygenase COX-2, creating a synergistic effect. This peptide also modulates dopamine levels, effectively antagonizing catalepsy induced by the dopamine antagonist haloperidol. The interaction with the NO system and the stimulation of VEGF receptors contribute to BPC-157’s enhanced clinical efficacy.
[BPC-157 EFFECTS ON MUSCULOSKELETAL SOFT TISSUE HEALING](https://blog.lotilabs.com/2020/01/26/the-unique-power-of-bpc-157-for-healing-injuries-in-rats/)
According to some controlled animal experimental studies, BPC-157’s effects include:
Potent anti-inflammatory properties.
Promoting angiogenesis and vasculogenesis.
Accelerating wound healing (liver, lung, colon, and gastric lesions).
Attenuating antianxiety and antidepressant effects.
Reversing specific motor abnormalities in Parkinson’s disease models.
Alleviating peripheral vascular occlusion disturbances by activating alternative bypass pathways to restore blood flow.
Therapeutic Applications
BPC-157 has demonstrated significant beneficial effects on wound healing across various tissues, including skin, muscle, tendon, ligament, and bone. Its efficacy extends to the gastrointestinal tract, where it promotes healing of gastric lesions and other injuries. This peptide has also been used to treat bleeding disorders, showcasing its versatility in medical applications. The ability of BPC-157 to accelerate wound healing and tissue repair makes it a promising candidate for treating a wide range of injuries and conditions.
Neuroprotective Effects
BPC-157 exhibits remarkable neuroprotective effects, making it a potential therapeutic agent for neurological conditions. It has been shown to counteract brain lesions and facilitate recovery from severe muscle weakness associated with such lesions. In animal models, BPC-157 has demonstrated therapeutic effects on spinal cord injuries, including cases of tail paralysis. Additionally, it has shown beneficial effects on conditions like stroke and schizophrenia, highlighting its potential in neuroprotection and recovery.
BPC-157 SIDE EFFECTS
The side effects of BPC157 seen in animal test subjects (if any) are usually mild when used at the proper dosage.
Some side effects noticed include:
Periods of either hyperthermia or hypothermia
Changes in appetite and weight
Fatigue
Headaches
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Jelovac N., Sikiric P., Rucman R., Petek M., Marovic A., Perovic D., Seiwerth S., Mise S., Turkovic B., Dodig G., Miklic P., Buljat G., Prkacin I. Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats. J. Pharmacol. 1999;379(1):19–31.
Tkalcević VI, et al. Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression. Eur J Pharmacol. (2007).
Sikirić P, et al. Pentadecapeptide BPC 157 interactions with adrenergic and dopaminergic systems in mucosal protection in stress. Dig Dis Sci. (1997)
Sikiric P, et al. The antidepressant effect of an anti-ulcer pentadecapeptide BPC 157 in Porsolt’s test and chronic unpredictable stress in rats. A comparison with antidepressants. J Physiol Paris. (2000).
Klicek R, et al. Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability. J Physiol Pharmacol. (2013).
Conclusion
BPC-157 is a synthetic peptide with a wide array of potential therapeutic applications, including wound healing, tissue repair, and musculoskeletal soft tissue healing. Its mechanism of action involves interaction with the nitric oxide system, stimulation of VEGF receptors, and modulation of dopamine levels. BPC-157 has shown beneficial effects on wound healing, bleeding disorders, and neuroprotective effects. However, more rigorous clinical trials are necessary to fully establish the therapeutic and toxic profiles of BPC-157, paving the way for its potential use in human medicine.
