WHAT IS CARDARINE (GW501516) | Buy GW-501516 10MG per ML
06February 6, 2023
Cardarine, also known as GW501516, is a chemical compound that was initially developed in the early 1990s. Initial research conducted through a research collaboration between two pharmaceutical companies showed promising results for treating conditions such as hyperlipidemia and obesity. However, further animal studies revealed concerning side effects, particularly its link to rapid cancer development, which ultimately led to the cessation of human clinical trials.
Introduction to Cardarine
Cardarine, also known as GW501516, is a synthetic compound that serves as a metabolic modulator. Initially developed in the 1990s, Cardarine was explored as a potential treatment for various diseases, including obesity and metabolic disorders. Researchers were intrigued by its ability to regulate lipid and glucose metabolism, which could have significant therapeutic benefits. However, due to concerns over its safety and potential for abuse, Cardarine was abandoned as a drug candidate. Today, it is banned by the World Anti-Doping Agency (WADA) for use in athletic competitions, reflecting its controversial status in the world of sports and medicine.
WHAT IS CARDARINE (GW501516) | Buy GW-501516 10MG per ML
Cardarine (GW501516) is a synthetic aromatic ether that is phenoxy acetic acid, demonstrating its ability to increase fat burning capacity, boost metabolism, prevent obesity, and increase muscle growth in mice.
Buy Cardarine from Loti Labs, your trusted source for research liquids. It is sold in liquid form in 10mg per ml vials for research purposes only and not for human consumption.
WHAT IS CARDARINE (GW501516) ?
Cardarine, also known as GW501516, GW1516, or Endurobol, is a synthetic Peroxisome Proliferator-Activated Receptor (PPAR) beta/delta Agonist. It is not a selective androgen receptor modulator, as previously thought in some circles.
PPARβ/δ receptors are in most tissues of animal test subjects like the liver, intestine, kidney, abdominal adipose tissue, and skeletal muscle.
It is necessary for fatty acid oxidation in skeletal and cardiac muscles. It also regulates blood cholesterol concentrations, reduces adiposity, and glucose levels, preventing obesity. Cardarine aims to improve overall cardiovascular functions, including maintaining healthy blood flow.
STRUCTURE OF CARDARINE
IUPAC Name: 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
Molecular Formula: C21H18 F3NO3S2
Molecular weight: 453.5 g/moll
CAS number: 317318-70-0
MECHANISM OF ACTION: PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR
Cardarine regulates glucose and lipid homeostasis. It acts on the PPARβ/δ receptors in most rat tissues to regulate fatty acid oxidation.
A human study conducted in 2007, which involved a small group of 24 healthy volunteers who were administered Cardarine or a placebo, explored the drug’s potential effects on blood lipid levels, specifically focusing on changes in HDL cholesterol and triglycerides, though it highlights the need for larger-scale studies to confirm these findings.
It also decreases serum triglycerides, preventing high-fat diet-induced obesity. It increases insulin sensitivity and improves symptoms associated with metabolic syndrome by regulating the genes encoding fatty acid metabolizing enzymes in skeletal muscle and lipogenic proteins in the liver.
Potential Research Applications of Cardarine
Research suggests that Cardarine may offer interesting research applications, particularly in metabolism and energy utilization models. Laboratory investigations indicate that this compound might influence metabolic processes by potentially increasing energy expenditure and enhancing lipid oxidation capacity in research settings. This metabolic modification could present interesting avenues for studying weight management mechanisms more efficiently. Additionally, preclinical studies with experimental models have demonstrated that Cardarine may influence physical capacity parameters by potentially enhancing endurance and muscular function. While these preliminary findings appear promising in controlled research environments, it’s important to note that comprehensive long-term studies remain limited, and the extended effects of Cardarine in research contexts require further investigation.
Cardarine in Experimental Performance Models
Research suggests that Cardarine’s potential influence on physical capacity parameters has made it an interesting subject for laboratory investigations focused on performance metrics. The compound is being studied for its possible effects on endurance parameters, tissue development, and overall functional capacity in experimental models. However, it’s worth noting that Cardarine is classified as a prohibited substance by regulatory bodies, and research must be conducted within appropriate ethical frameworks. Despite these important considerations, interest in studying this compound continues in controlled laboratory settings. It remains crucial for researchers to balance scientific inquiry with rigorous ethical standards when investigating these biochemical mechanisms.
CARDARINE (GW501516) EFFECTS: INFLUENCE ON LIPID UTILIZATION
Recent experimental investigations with research models have suggested that cardarine may play a significant role in:
Potentially addressing metabolic dysregulation in laboratory settings.
Enhancing fatty acid oxidation processes in muscle tissue, adipose structures, and hepatic systems.
Modifying glucose transport mechanisms in skeletal muscle and adipose tissue models.
Reducing localized glucocorticoid synthesis in experimental contexts.
Research suggests Cardarine might also influence lipid utilization by potentially altering metabolic substrate preference from glucose to lipids in research models.
CARDARINE (GW501516) RESEARCH OBSERVATIONS: CONCERNING OUTCOMES IN LABORATORY STUDIES
Cardarine has demonstrated notable outcomes in preclinical research studies. These observations include:
Increased indicators of hepatic stress in research models
Concerning cellular proliferation in various organ systems including intestinal, mammary, and prostate tissues in laboratory animals. Preclinical investigations revealed that the compound was associated with accelerated cellular changes in multiple systems, which led researchers to discontinue further investigations and development initiatives.
Elevated risk of developmental irregularities during gestation periods in experimental animals.
Research Quantities and Laboratory Protocols
The scientific literature lacks conclusive data regarding appropriate experimental quantities of Cardarine for laboratory investigations, as this compound never progressed to approved status for human research models. However, research suggests that quantities ranging from 2.5-10 mg in controlled experimental settings may demonstrate potential for altered metabolic parameters and enhanced cellular energy utilization. It’s important to note that these findings primarily emerge from non-human mammalian models, with limited data available in other research contexts. The scientific community should be aware that this compound appears on the World Anti-Doping Agency’s prohibited substances list, which has significant implications for athletic testing protocols. Given the current gaps in comprehensive laboratory studies and potential research considerations, the scientific community advocates for cautious approaches when designing experiments involving this particular compound.
LOOKING FOR WHERE TO OBTAIN CARDARINE (GW501516) FOR RESEARCH PURPOSES? WORLD ANTI DOPING AGENCY ADVISORY
When conducting investigations with research compounds, it is fundamentally essential to source materials from established laboratories to ensure experimental integrity and reliability of subsequent data collection.
Loti Labs provides research-grade materials at competitive price points, accompanied by comprehensive analytical verification documentation. Our technical support team offers detailed consultation for research applications, and we maintain a comprehensive satisfaction guarantee for all Cardarine research compounds.
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References:
Oliver WR Jr, Shenk JL, Snaith MR, et al. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U. S. A. 2001;98(9):5306–5311. doi:10.1073/pnas.091021198
Dressel U, Allen TL, Pippal JB, Rohde PR, Lau P, Muscat GE. The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol Endocrinol. 2003;17(12):2477–2493. doi:10.1210/me.2003-0151
National Center for Biotechnology Information. PubChem Database. Endurobol, CID=9803963, https://pubchem.ncbi.nlm.nih.gov/compound/Endurobol (accessed on Dec. 8, 2019)
Oliver WR Jr, Shenk JL, Snaith MR, et al. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U S A. 2001;98(9):5306–5311. doi:10.1073/pnas.091021198
