RAD-140 belongs to a class of research chemicals called selective androgen receptor modulators, or SARMs. It mimics the activity of testosterone in the body.

Studies using RAD-140 on animal models demonstrated its potential tissue-selective androgenic/anti-androgenic activities. 

Buy RAD-140 from Loti Labs, your trusted source for research liquids. It is sold in liquid form in 10mg per ml vials for research ONLY and not human consumption!

WHAT IS RAD-140?

As mentioned earlier, RAD-140, also known as testolone, is a selective androgen receptor modulator that binds to androgen receptors found in different areas of the body. Animal studies show that these receptors interact with androgens, which are a group of steroid hormones. The androgens include testosterone, dihydrotestosterone, and androstenedione.

RAD-140 is of particular interest to researchers because it is selective about where it works. It targets mostly muscles and bones and appears to have minimal effects on the prostate and other organs.

STRUCTURE OF RAD-140

IUPAC Name: 2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile

Molecular Formula: C₂₀H₁₆CIN₅O₂

Molecular weight: 393.8 g/mol

CAS number: 1182367-47-0

MECHANISM OF ACTION

RAD-140 acts as an agonist in select tissues, such as skeletal muscle and bone, where it binds to and activates androgen receptors (ARs). 

In the prostate and breasts, RAD140 acts as an antagonist and blocks AR activation and AR-mediated cellular proliferation. Compared to anabolic agents, SARMs have reduced androgenic properties.

RAD-140 EFFECTS

Some researchers believe that RAD-140 could potentially treat hormone-related or muscle-wasting disorders. Other benefits include:

• Improve bone formation
• Improves muscle mass and strength
• May inhibit both the growth of the prostate in males rats
• May inhibit androgen receptor-dependent breast cancer
• Burns fat
• Boosts testosterone

RAD-140 SIDE EFFECTS

Common side effects include:

• Nausea
• Headaches
• Increased Aggression
• Hormonal disorder
• Acne
• Hair loss

LOOKING FOR WHERE TO BUY RAD-140 ONLINE

When searching for research liquids online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research. 

Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy RAD-140 for sale. 

Visit our website or contact us today to buy RAD-140 online.

References:

1. Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 2014 Apr;155(4):1398-406. doi: 10.1210/en.2013-1725. Epub 2014 Jan 15. PMID: 24428527; PMCID: PMC3959610.

2. Hamson DK, Wainwright SR, Taylor JR, Jones BA, Watson NV, Galea LA (September 2013). “Androgens increase survival of adult-born neurons in the dentate gyrus by an androgen receptor-dependent mechanism in male rats”. Endocrinology. 154 (9): 3294–304. doi:10.1210/en.2013-1129. PMID 23782943.

3. Miller CP, Shomali M, Lyttle CR, O’Dea LS, Herendeen H, Gallacher K, et al. (February 2011). “Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140”. ACS Medicinal Chemistry Letters. 2 (2): 124–9. doi:10.1021/ml1002508. PMC 4018048. PMID 24900290.

1. Yu Z, He S, Wang D, Patel HK, Miller CP, Brown JL, et al. (December 2017). “Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action”. Clinical Cancer Research. 23 (24): 7608–7620. doi:10.1158/1078-0432.CCR-17-0670. PMID 28974548