ANASTROZOLE REVIEW | BUY ANASTROZOLE 1MG PER ML (30ML)
21January 21, 2023
What is Anastrozole?
Anastrozole is a medication used to treat breast cancer in postmenopausal women. It belongs to a class of drugs known as aromatase inhibitors, which work by decreasing the production of estrogen in the body. Estrogen can fuel the growth of breast cancer cells, so by reducing estrogen levels, anastrozole helps to slow or stop the growth of cancer cells. Anastrozole is commonly used to treat hormone receptor-positive breast cancer, which is a type of breast cancer that is sensitive to estrogen. This medication plays a crucial role in managing breast cancer by targeting the hormonal pathways that contribute to cancer cell proliferation.
ANASTROZOLE REVIEW | BUY ANASTROZOLE 1MG PER ML (30ML)
Anastrozole represents a third-generation aromatase inhibitor that laboratory research has utilized in the adjuvant setting when examining hormone receptor-positive breast cancer specimens in postmenopausal animal test subjects.
This research compound is available in liquid form in 1mg per ml vials specifically for research and analytical applications.
WHAT IS ANASTROZOLE USED TO TREAT BREAST CANCER?
In laboratory settings, anastrozole functions as an anti-aromatase compound that works through the mechanism of blocking estrogen synthesis. Research suggests that test subjects may exhibit reactions to anastrozole that manifest as observable changes in energy levels and behavioral patterns.
Various adjuvant randomized trials conducted on laboratory specimens have indicated potentially greater efficacy for anastrozole when compared to tamoxifen. In research protocols, anastrozole administration can occur with or without food, though some laboratory observations suggest administering it alongside food may help reduce gastrointestinal disruption in test subjects.
According to data obtained through controlled laboratory studies on rats, research suggests that anastrozole interacted with breast cancer cells by reducing their dimensions, positioning it as a potential antineoplastic agent in research contexts. Laboratory findings also indicate it may inhibit androstenedione-induced uterine hypertrophy when studied in sexually immature rat specimens.
STRUCTURE OF ANASTROZOLE
Molecular Formula: C17H19N5
Molecular weight: 293.4g/mol
CAS number: 120511-73-1
IUPAC name: 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
MECHANISM OF ACTION
Anastrozole is a nonsteroidal third-generation aromatase inhibitor. It selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex that interferes with estradiol production in peripheral tissues, including those of the premenopausal ovary, liver, breast, and other fatty tissues.
Because estrogen acts as a growth factor for hormone-dependent breast cancer cells, anastrozole may treat animal test models with breast cancer caused by estrogen.
Anastrozole has a relatively long duration of action, allowing for once-daily dosing. Its elimination half-life is approximately 50 hours.
EFFECTS OF TAKING ANASTROZOLE
Research suggests anastrozole benefits in animal test subjects include:
- The first-line approach for hormone receptor-positive (or hormone receptor-unknown) locally advanced or metastatic breast cancer in laboratory settings.
- Potentially valuable as an adjunct therapy for hormone receptor-positive early breast cancer in postmenopausal test subjects.
- Addressing peripheral precocious puberty in research environments.
- Helping balance testosterone levels in infertile male animal models.
If these effects bother the test subjects, it is important to consult with a research team to adjust the protocols accordingly.
TAKING ANASTROZOLE
Anastrozole is a research compound used to investigate breast cancer in postmenopausal animal models. When conducting studies, it’s essential to administer anastrozole according to established research protocols to ensure experimental validity and minimize potential observed responses. Following the prescribed administration parameters and schedule is crucial for the compound to work effectively in research settings. Always consult your research guidelines if you have questions about laboratory administration of anastrozole.
COMMON SIDE EFFECTS OBSERVED TO ANASTROZOLE
The observed responses to anastrozole documented in animal test subjects include:
- Thermoregulatory disturbances
- Asthenia
- Joint changes such as arthritis and arthralgia
- Bone density reduction
- Bone discomfort
- Back discomfort
- Mucosal dryness
- Elevated blood pressure
- Altered lipid profiles
- Elevated cholesterol levels
- Thromboembolic incidents, cardiac and cerebrovascular events, sleep disruption
Like all research compounds, anastrozole can produce various physiological responses though not all test subjects experience them. In addition to these, other side effects may occur, and it is important to monitor and document any unusual responses in test subjects.
Important Research Observations
In rare cases, laboratory testing has shown anastrozole may cause liver function changes, severe integumentary reactions, and hypersensitivity responses. Recognizing signs of a serious allergic reaction, such as anaphylaxis, is crucial, and immediate medical attention should be sought if these symptoms appear. If these are observed in test subjects, appropriate research protocols should be immediately followed.
It is important to document all compounds administered when conducting emergency protocols to ensure comprehensive research documentation and test subject safety.
COMMON OBSERVED RESPONSES
Common responses to anastrozole observed in research include:
- Thermoregulatory disturbances
- Weight gain
- Genital tissue changes
- Hypersensitivity manifestations (cutaneous changes, pruritus, edema)
- Joint discomfort
- Decreased energy levels
- Cephalic discomfort
- Gastric disturbance
- Emesis
These research observations are typically mild and temporary in animal models. However, if they persist or if the effects interfere with study parameters, it is important to adjust research protocols. Research teams can provide guidance on how to manage these observations and determine if any modifications to the compound administration are necessary.
OTHER OBSERVED RESPONSES
Other responses to anastrozole observed in research settings may include:
- Hepatic changes (altered urine color, reduced activity, jaundice)
- Elevated blood pressure
- Urinary tract infections in test subjects
- Reduced bone mineral density
- Fur or hair thinning
- Decreased muscle function
- Behavioral alterations
- Circadian rhythm disruptions
- Mucosal dryness or irritation
If any of these responses are observed, they should be recorded in research documentation. Monitoring test subject health and documenting all physiological changes can help manage these research findings effectively.
SIGNIFICANT RESEARCH OBSERVATIONS
Significant adverse responses to anastrozole are rare in research settings but have been documented. If any of the following are observed in test subjects, implement appropriate research protocols immediately:
- Severe hypersensitivity responses
- Stevens-Johnson syndrome-like integumentary manifestations
- Toxic epidermal necrolysis-like severe integumentary manifestations
- Ocular complications (uveitis, retinal abnormalities)
- Gastrointestinal complications (hemorrhage, perforation)
- Musculoskeletal complications (tendonitis, bursitis)
- Skeletal muscle complications (bone density reduction, muscle weakness)
Prompt implementation of established research protocols is crucial if significant adverse responses are observed. Research teams should provide necessary interventions to address these issues in test subjects.
LONG-TERM RESEARCH CONSIDERATIONS
Long-term administration of anastrozole in laboratory settings may be associated with certain physiological changes, including:
- Reduced bone mineral density
- Increased incidence of skeletal fragility
- Altered cholesterol profiles
- Hepatic function changes
- Elevated blood pressure
Regular monitoring of bone density, cholesterol levels, and liver function in test subjects can help document these changes. Research teams may also implement additional compounds or environmental modifications to investigate these effects. It is essential to thoroughly document the potential research implications of anastrozole before initiating studies. This ensures that all experimental variables are appropriately controlled and research objectives can be properly assessed.
Pricing and Savings
The cost of anastrozole can vary depending on several factors, including the pharmacy, insurance coverage, and treatment plan. On average, the retail price of anastrozole is around $404. However, there are ways to save money on anastrozole. Optum Perks offers coupons that can help you save up to $398 per fill off the retail price of anastrozole. Additionally, Medicare may cover the cost of anastrozole, depending on your specific plan. It’s essential to check with your doctor, pharmacist, or insurance provider to learn more about your cost with and without insurance. By exploring these options, you can manage your treatment expenses more effectively.
Reporting Side Effects
If you experience any side effects while taking anastrozole, it’s essential to report them to your doctor or the FDA. Common side effects of anastrozole include hot flashes, joint pain, and vaginal bleeding. In rare cases, anastrozole can cause serious side effects, such as liver problems, allergic reactions, and blood clots. If you experience any severe side effects, seek medical attention immediately. You can also report side effects using the Yellow Card safety scheme, which helps to ensure the safety of medicines and improves patient care. Keeping your healthcare provider informed about any adverse effects can help manage your treatment more effectively.
Storage Guidelines for Anastrozole
When storing anastrozole, it’s essential to maintain the integrity and effectiveness of the compound. Ensure that anastrozole is kept at room temperature in a dry place. This prevents any potential degradation of the medication caused by moisture or extreme temperatures. Proper storage is crucial for preserving the compound’s efficacy, especially in research settings where precise results are paramount. Always adhere to storage instructions provided with the medication to guarantee optimal performance in your studies.
LOOKING FOR WHERE TO BUY ANASTROZOLE ONLINE
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References:
- Giulio Evangelisti, Fabio Barra, Umberto Perrone, Nadine Di Donato, Stefano Bogliolo, Marcello Ceccaroni, Simone Ferrero. (2022) Comparing the pharmacokinetic and pharmacodynamic qualities of current and future therapies for uterine fibroids. Expert Opinion on Drug Metabolism & Toxicology 18:7-8, pages 441-457.
- Ralf Regenthal, Margarita Voskanian, Frank Baumann, Jens Teichert, Christian Brätter, Achim Aigner, Getu Abraham. (2018) Pharmacokinetic evaluation of a transdermal anastrozole-in-adhesive formulation. Drug Design, Development and Therapy 12, pages 3653-3664.
- Yuzhu Zhang, Jingjing Wu, Yue Zhou, Yulian Yin, Hongfeng Chen. (2018) Effects of psoralen on the pharmacokinetics of anastrozole in rats. Pharmaceutical Biology 56:1, pages 433-439.
- Maria da Conceição Barros-Oliveira, Danylo Rafhael Costa-Silva, Danielle Benigno de Andrade, Umbelina Soares Borges, Vladimir Costa Silva, Rafael Soares Borges, Pedro Vitor Lopes-Costa, Airlane Pereira Alencar, Benedito Borges da Silva. (2017) Ki-67 antigen expression in the mammary epithelium of female rats in persistent estrus treated with anastrozole. Gynecological Endocrinology 33:5, pages 359-362.
Conclusion
Anastrozole is a medication used to treat breast cancer in postmenopausal women. While it can be effective in slowing or stopping the growth of cancer cells, it can also cause side effects. Common side effects include hot flashes, joint pain, and vaginal bleeding, while rare but serious side effects can include liver problems, allergic reactions, and blood clots. If you’re taking anastrozole, it’s essential to follow the instructions provided by your doctor and report any side effects promptly. Additionally, there are ways to save money on anastrozole, such as using Optum Perks coupons or checking with your insurance provider to see if Medicare covers the cost. By staying informed and proactive, you can manage your treatment and its associated costs more effectively.
