Triptorelin Peptide is a synthetic GnRH that research shows may be beneficial in the palliative treatment of advanced prostate cancer observed in animal test subjects. 

Triptorelin is available in lyophilized powder form and sold in 100 mcg vials at Loti Labs.

Buy triptorelin for sale for research purposes only and not for human consumption.

WHAT IS TRIPTORELIN PEPTIDE?

Triptorelin is a synthetic decapeptide (H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2) agonist of the naturally occurring Gonadotropin-releasing hormone produced in the hypothalamus. 

It acts on the Gonadotropin-releasing hormone receptors and reversibly represses gonadotropin secretion in the pituitary gland stimulating the release of Luteinizing hormone (LH) and Follicular stimulating hormone (FSH). It increases the production and release of testosterone by the male testes and estrogen by the female ovaries and placenta. 

Animal studies comparing triptorelin to native GnRH found that triptorelin had 13-fold higher releasing activity for luteinizing hormone and 21-fold higher releasing activity for follicle-stimulating hormone.

STRUCTURE OF TRIPTORELIN

Sequence: H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2

Molecular Formula: C₆₄H₈₂N₁₈O₁₃

Molecular weight: 1311.4 g/mol

CAS number: 57773-63-4

MECHANISM OF ACTION

Triptorelin causes a transient surge of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, and testosterone when administered to animal test subjects. The time, peak, and decline of testosterone in their body varies depending on the dose administered.

Triptorelin is eliminated through the kidneys and the liver and is resistant to enzymatic breakdown, and has a prolonged half-life of 3 hours compared to native GnRH of about 2 to 4 minutes.

TRIPTORELIN USES

Triptorelin’s benefits are due to its phenomenon of increasing sex hormones. Below are its uses:

• Palliation of prostate cancer
• Chemical castration
• Improving endometriosis
• Breast cancer management
• Improving precocious puberty in male rats

TRIPTORELIN PEPTIDE SIDE EFFECTS

Along with its benefits, triptorelin may cause some unwanted effects typical of androgen deprivation in animal test studies. They include:

• Hot flushes
• Skeletal pains
• Impotence
• Headaches
• Fatigue
• Hypertension
• Diarrhea and vomiting
• Insomnia
• Urinary retention and urinary tract infections
• Anemia
• Embryo-fetal toxicity

LOOKING FOR WHERE TO BUY TRIPTORELIN ONLINE

When searching for research peptides online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research. 

Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy triptorelin for sale. 

Visit our website or contact us today to buy triptorelin online.

References:

1. Lahlou N, Carel JC, Chaussain JL, Roger M: Pharmacokinetics and pharmacodynamics of GnRH agonists: clinical implications in pediatrics. J Pediatr Endocrinol Metab. 2000 Jul;13 Suppl 1:723-37. [Article]

2. National Center for Biotechnology Information. PubChem Database. Triptorelin, CID=25074470, https://pubchem.ncbi.nlm.nih.gov/compound/Triptorelin (accessed on Dec. 20, 2019)

3. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): the National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Triptorelin. [Updated 2018 Mar 22]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548756/

1. Leschek EW, Flor AC, Bryant JC, Jones JV, Barnes KM, Cutler GB Jr. Effect of Antiandrogen, Aromatase Inhibitor, and Gonadotropin-releasing Hormone Analog on Adult Height in Familial Male Precocious Puberty. J Pediatr. 2017;190:229–235. doi:10.1016/j.jpeds.2017.07.047