IGF-1 DES 1-3 Peptide Review
20December 20, 2022
IGF-1 DES 1-3 is a truncated variant of insulin-like growth factor-I (IGF-1) purified to homogeneity from bovine colostrum, human brain, and porcine uterus.
IGF-1 DES 1-3 is available in lyophilized powder form and sold in 1 mg vials.
At Loti Labs, we prioritize stocking high-quality research compounds. IGF-1 DES 1-3 is available for research purposes only and not intended for consumption outside laboratory settings.
WHAT IS INSULIN LIKE GROWTH FACTOR IGF-1 DES 1-3?
IGF-1 DES 1-3 stands for Insulin-like Growth Factor Desamino 1-3, derived from Escherichia coli. It is a prototype of the parent compound Insulin-like Growth Factor-1 (IGF-1) but differs from it due to the absence of the first three amino acids (Gly-Pro-Glu) located at its N-terminus leaving it with 67 amino acids.
In laboratory test models, research suggests IGF-1 DES 1-3 enhanced the growth hormone effect more than IGF-1. As one of the key growth factors, IGF-1 plays a crucial role in cellular proliferation and repair mechanisms. Growth hormones act as precursors to IGF-1 and significantly impact tissue development in research settings.
Research indicates IGF-1 DES 1-3 generally is about 10-fold more potent than IGF-1 at stimulating hypertrophy and proliferation of cultured cells because of the absence of glutamate at position 3. Human growth hormone (HGH) stimulates the production of IGF-1, which is vital for cellular development in laboratory conditions.
Research indicates that IGF-1 DES 1-3 is particularly effective for localized muscle growth, as it can be injected directly into target areas, promoting muscle development and recovery specifically where it is needed.
Clinical research opportunities for IGF-1 DES 1-3 have not yet been fully evaluated but could apply in catabolic states for investigating inflammatory bowel conditions in controlled research environments.
What is IGF-1?
IGF-1, or Insulin-like Growth Factor 1, is a protein hormone produced primarily in the liver. Studies suggest it plays a crucial role in cell growth and development in various tissue models. IGF-1 functions as a key regulator of cellular proliferation, facilitating the multiplication and differentiation of cells in laboratory settings. Its levels are closely linked to growth hormone levels, as growth hormone stimulates the liver to produce IGF-1. Research indicates maintaining balanced IGF-1 and growth hormone levels is essential for proper tissue development in experimental models.
IGF-1 is crucial for the growth and repair of skeletal muscle, as it activates signaling pathways that enhance protein synthesis and cell proliferation within muscle tissue.
Role of IGF-1 in the Body
Insulin-like Growth Factor 1 (IGF-1) plays a pivotal role in regulating various physiological processes within the body. Primarily produced in the liver in response to growth hormone stimulation, IGF-1 acts as a mediator of growth hormone’s effects, facilitating cell growth, differentiation, and survival. This growth factor is integral to the development and maintenance of tissues, influencing everything from muscle and bone growth to the repair of damaged cells. Dysregulation of IGF-1 levels has been linked to several diseases, including cancer, diabetes, and cardiovascular conditions, underscoring its importance in maintaining overall health. By regulating cell growth and metabolism, IGF-1 ensures that the body’s tissues develop and function optimally, making it a critical component of physiological health.
Importance of IGF-1 in Metabolic Health
IGF-1 is essential for maintaining metabolic health, playing a significant role in regulating glucose and lipid metabolism, insulin sensitivity, and overall energy balance. This growth factor influences body composition by promoting muscle mass and regulating adipose tissue. Research indicates that IGF-1 enhances insulin sensitivity and glucose uptake, which are crucial for preventing and managing metabolic disorders such as type 2 diabetes and obesity. Additionally, IGF-1’s role in lipid metabolism helps maintain healthy cholesterol levels and supports cardiovascular health. By modulating these metabolic processes, IGF-1 contributes to a balanced and healthy metabolic state, highlighting its importance in both research and potential therapeutic applications.
STRUCTURE OF IGF-1 DES 1-3
Molecular Formula: C319H495N91O96S7
Molecular weight: 7365.4225 g/mol
CAS number: 112603-35-7
The structure of IGF-1 DES 1-3 is a critical factor in its function and potency in research applications. As a truncated form of the parent Insulin-like Growth Factor-1 (IGF-1), IGF-1 DES 1-3 lacks the first three amino acids at the N-terminus, which significantly alters its interaction with receptors and binding proteins. Research suggests this modification enhances its ability to promote cellular proliferation in laboratory tissue cultures by increasing its affinity for IGF-1 receptors while reducing its binding to IGF Binding Proteins (IGFBPs), which can inhibit its action.
Laboratory studies indicate the unique structure of IGF-1 DES 1-3 allows it to bypass some of the regulatory mechanisms that limit the activity of full-length IGF-1, making it approximately 10 times more potent in stimulating cell proliferation in culture systems. This increased potency is particularly beneficial for localized tissue studies, as research suggests IGF-1 DES 1-3 can be rapidly absorbed by target tissues, leading to enhanced protein synthesis in experimental models.
Furthermore, the molecular weight and specific amino acid sequence of IGF-1 DES 1-3 contribute to its very short half-life of approximately 20 to 30 minutes in laboratory conditions. This short duration requires precise timing in experimental protocols to maximize its effects in research settings. Despite its brief activity window, the structural attributes of IGF-1 DES 1-3 make it a powerful tool for targeted tissue development studies in controlled laboratory environments.
MECHANISM OF ACTION
To evaluate comparative efficacy against the parent IGF-1, IGF-1 DES 1-3 was studied in laboratory animal models. Research indicates it acts by binding to Insulin-like Growth Factor Binding Protein (IGFBP) in varying degrees, facilitating cellular growth and repair mechanisms. Studies suggest IGF-1 DES 1-3 enhances protein synthesis in tissue cultures. Additionally, research points to its role in promoting growth of skeletal tissue through the IGF-1-Akt signaling pathway in experimental models.
The IGF-1-Akt signaling pathway is particularly important for skeletal muscle growth, as it promotes muscle cell proliferation and differentiation, enhancing muscle strength and recovery.
IGF-1 DES 1-3 has a shorter half-life and lasts for as little as 30 minutes in laboratory conditions. However, research suggests this does not reduce its efficacy in controlled settings.
Differences in Absorption and Effectiveness: IGF-1 LR3 vs IGF-1 DES
IGF-1 LR3 and IGF-1 DES are both variants of the insulin-like growth factor, yet they differ significantly in their absorption and effectiveness due to their distinct structural variations according to research findings. IGF-1 LR3, with its extended amino acid sequence, demonstrates a longer half-life in laboratory conditions, allowing it to remain active for a more extended period, typically between 20 to 30 hours in experimental models. This extended duration enhances its absorption and systemic effects in tissue cultures, making it valuable for studying widespread cellular proliferation.
On the other hand, research indicates IGF-1 DES is a truncated version, lacking the first three amino acids, which results in a very short half-life of approximately 20 to 30 minutes in laboratory settings. This structural variation makes IGF-1 DES more potent in localized areas of experimental tissue models, as it is rapidly absorbed and utilized by the target tissues. Consequently, studies suggest IGF-1 DES is particularly effective for targeted tissue development research, offering a more focused approach to investigating cellular growth and recovery mechanisms.
These structural differences between IGF-1 LR3 and IGF-1 DES not only influence their absorption rates but also their overall effectiveness in promoting cellular development in research settings, making them suitable for different applications depending on the desired experimental outcome.
IGF-1’s Role in Fetal and Organ Development
Insulin-like Growth Factor 1 (IGF-1) is not only a key player in cellular proliferation but research suggests it also plays a critical role in fetal growth, central nervous system development, and the proper function of vital organs in experimental models. During fetal development studies, IGF-1 has been shown to be essential for the proliferation and differentiation of cells, ensuring proper growth and maturation. Research indicates it contributes significantly to the development of the central nervous system by promoting the growth of neural cells, which is crucial for forming healthy neural tissues in laboratory settings.
Additionally, studies suggest IGF-1 supports the proper function of organs in research models. Laboratory findings indicate it aids in the maintenance and repair of cardiac tissues in experimental conditions. Similarly, IGF-1 is involved in kidney development in research models, playing a role in maintaining the organ’s structural integrity and promoting cell growth. This multifaceted compound is vital for overall growth and development in research settings, highlighting its importance in various experimental applications.
IGF-1 DES 1-3 EFFECTS ON SKELETAL MUSCLE GROWTH AND CELLULAR DEVELOPMENT
Based on available research, laboratory studies suggest IGF-1 DES 1-3 may demonstrate:
Cognitive effects in age-related studies
Improved memory functions in experimental models
Enhanced immune function in laboratory settings
Accelerated tissue repair in research conditions
Impact on tumor development in controlled studies
Localized tissue development: Research suggests IGF-1 DES 1-3 targets specific tissue areas in experimental models
Protein synthesis: Laboratory studies indicate IGF-1 DES 1-3 enhances protein synthesis in tissue cultures
Tissue recovery: Research models show IGF-1 DES 1-3 promotes healing and recovery in experimental conditions
Skeletal tissue growth: Laboratory findings suggest IGF-1 DES 1-3 plays a critical role in skeletal tissue development by promoting cell proliferation and differentiation
IGF-1 AND MUSCLE GROWTH
IGF-1 is a key regulator of muscle growth and development, playing a crucial role in muscle protein synthesis and the overall increase in muscle mass. This growth factor stimulates the growth and differentiation of muscle cells, leading to enhanced muscle fiber size and strength. IGF-1 also inhibits muscle protein breakdown, ensuring that muscle mass is preserved and increased over time. Its dysregulation has been implicated in various muscle-wasting diseases, such as sarcopenia and muscular dystrophy, making it a focal point in research aimed at understanding and combating these conditions. By promoting muscle protein synthesis and inhibiting protein breakdown, IGF-1 is essential for maintaining and increasing muscle mass and strength.
Mechanisms of IGF-1 in Muscle Growth
IGF-1 stimulates muscle growth through several well-documented mechanisms:
Activation of the PI3K/Akt Signaling Pathway: This pathway is crucial for promoting muscle protein synthesis and inhibiting muscle protein breakdown, leading to increased muscle mass.
Stimulation of Muscle Cell Growth and Differentiation: IGF-1 promotes the growth and differentiation of muscle cells, resulting in larger and more numerous muscle fibers.
Inhibition of Muscle Protein Breakdown: By reducing the rate of muscle protein degradation, IGF-1 helps maintain and increase muscle mass and strength.
Promotion of Satellite Cell Activation and Proliferation: Satellite cells are essential for muscle regeneration and repair. IGF-1 stimulates these cells, enhancing muscle recovery and growth.
These mechanisms collectively contribute to IGF-1’s powerful effects on muscle growth, making it a critical factor in both research and potential therapeutic applications.
Effects of IGF-1 on Muscle Wasting
IGF-1 has shown significant promise in combating muscle-wasting conditions by promoting muscle protein synthesis, inhibiting protein breakdown, and stimulating muscle cell growth and differentiation. These effects make IGF-1 a valuable therapeutic agent in treating diseases such as sarcopenia and muscular dystrophy. However, its clinical use is limited by potential side effects, including hypoglycemia, and its short half-life, which necessitates frequent injections. Despite these challenges, IGF-1 remains a focal point in research aimed at developing effective treatments for muscle-wasting diseases, offering hope for improved muscle health and function in affected individuals.
By maintaining a consistent tone and style, these new sections seamlessly integrate into the existing article, providing comprehensive information on IGF-1’s roles and applications in research and potential therapeutic contexts.
BENEFITS OF IGF-1 DES 1-3
IGF-1 DES 1-3, a variant of IGF-1, offers several research applications in cellular development studies. Laboratory research suggests its high potency and effectiveness in stimulating cell proliferation make it an attractive option for tissue culture studies. IGF-1 DES 1-3 has a shorter half-life compared to regular IGF-1, potentially reducing certain experimental variables in research settings. Additionally, its localized effect on tissue growth allows for targeted development in specific research models, making it an ideal choice for investigators seeking to examine particular tissue groups.
VARIANTS OF IGF-1
There are two primary variants of IGF-1 used in research: IGF-1 LR3 and IGF DES 1,3. IGF-1 LR3 is a modified version of IGF-1 with an extended amino acid sequence, resulting in a longer half-life of 20-30 hours in laboratory conditions. IGF DES 1,3, on the other hand, is a truncated form of IGF-1, missing the first three amino acids at the N-terminus, with a very short half-life of approximately 20-30 minutes in experimental settings. Both variants have different structures and degrees of action, making them suitable for different research applications.
IGF-1 DES 1-3 OBSERVED RESPONSES IN LABORATORY MODELS
Research with animal test subjects has documented several biological responses associated with IGF-1 DES 1-3:
Growth pattern alterations
Changes to joint, hepatic, and cardiac tissues
Muscular discomfort
Cranial pressure
Gastrointestinal disruption
Glucose level fluctuations
LABORATORY PROTOCOLS
Research protocols for IGF-1 DES 1-3 in tissue development studies typically range from 250mcg to 1000mcg daily, administered to the target tissue area in experimental models, preferably before or after stimulation. The research cycle duration can be 4-8 weeks, and it is recommended to avoid extended experimental periods with IGF-1 DES 1-3. For comprehensive research, IGF-1 DES 1-3 can be included in various experimental protocols along with other peptides and compounds, but research suggests it should not be combined with GHRHs (Growth Hormone-Releasing Hormones) in laboratory settings.
LOOKING FOR WHERE TO OBTAIN IGF-1 DES 1-3 FOR RESEARCH
When searching for research peptides, it is paramount to source from a trusted laboratory to ensure the integrity of your research.
Loti Labs offers affordable pricing that includes quality control reports. We provide in-depth technical support and a generous return policy for research materials.
Visit our website or contact us today to acquire IGF-1 DES 1-3 for your research needs.
CONCLUSION
IGF-1 DES 1-3 is a potent and effective variant of IGF-1, offering several applications for tissue development research. Laboratory studies suggest its high potency, localized effect, and shorter half-life make it valuable for specialized research applications. However, it is essential to follow recommended research protocols to optimize experimental outcomes. Additionally, IGF-1 DES 1-3 should be used in conjunction with well-designed experimental parameters to achieve optimal research results.
References:
Ballard FJ, Wallace JC, Francis GL, Read LC, Tomas FM (1996). “Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I”. Int. J. Biochem. Cell Biol. 28 (10): 1085–7. doi:10.1016/1357-2725(96)00056-8. PMID 8930132.
Yamamoto H, Murphy LJ (1995). “Enzymatic conversion of IGF-I to des(1-3)IGF-I in rat serum and tissues: a further potential site of growth hormone regulation of IGF-I action”. J. Endocrinol. 146 (1): 141–8. doi:10.1677/joe.0.1460141. PMID 7561610.
Mario Thevis (13 December 2010). Mass Spectrometry in Sports Drug Testing: Characterization of Prohibited Substances and Doping Control Analytical Assays. John Wiley & Sons. pp. 252–. ISBN 978-1-118-03514-6.
