What is CJC-1295 with DAC?
CJC-1295 With DAC is an exceptionally designed peptide mimicking Growth Hormone Releasing Hormone, causing the anterior pituitary to produce more growth hormone.
CJC-1295 DAC is available in lyophilized powder form and sold in 2 mg vials.
At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy CJC-1295 DAC for sale for research purposes only and not for human consumption.
WHAT IS CJC-1295 with DAC?
CJC-1295 is a synthetically modified and tetra-substituted form of Growth Hormone-Releasing Hormone (GHRH 1-29). The substitution of four amino acids from the core moiety makes CJC-1295 peptide more resistant to cleaving by proteolytic enzymes.
It contains a chain of 30 amino acids, a molecular weight of 3368.7, and molecular formula of C152H252N44O42. CJC-1295 works by binding to serum albumin a, the addition of Drug Affinity Complex or DAC prolongs the half-life of CJC-1295 as well as the duration of action in animal test subjects.
What is DAC
Drug Affinity Complex (DAC) increases the half-life of CJC-1295 by binding with serum albumin and preventing its degradation. The addition of DAC helps to slow down kidney excretion. For both in vivo and ex vivo mechanisms, DAC covalently bonds with albumin in order to resist peptide breakdown.
MECHANISM OF ACTION
After administering CJC-1295 DAC on animal test subjects, it reduced the production of the Dipeptidyl Aminopeptidase-IV (DPP-IV) enzyme.
DPP-IV is an antigenic enzyme involved in signal transduction, apoptosis or programmed cell death, and immune system regulation. It prolongs the half-life of Growth Hormone (GH) and IGF-1.
CJC-1295 With DAC EFFECTS
CJC-1295 peptide can dramatically increase Growth Hormone, and Insulin-like Growth Factor 1. The effects of which are:
- Increased protein synthesis.
- Increased bone density
- Increase lipolysis
- Improves quality of sleep
- Increased muscle growth
CJC-1295 DAC SIDE EFFECTS
Below are what researchers noticed during clinical trials with CJC-1295 DAC’s use in animal test studies.
- Anxiety
- Irritability
- Headaches
- Nausea
LOOKING FOR WHERE TO BUY CJC-1295 DAC ONLINE
When searching for research peptides online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research.
Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy cjc-1295 DAC for sale.
Visit our website or contact us today to buy cjc-1295 DAC online.
References:
- Alba, M. et al. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology, Endocrinology, and Metabolism.
- Jette, L. et al. (2005). hGRF1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: Identification of CJC-1295 as a long-lasting GRF analog. Endocrinology.
- Benquet, C. et al. (2004). (CJC-1295 (DAC-GRF), a long-acting GRF analog, enhances pulsatile GH secretion, increases IGF-I levels, and restores linear growth. Program of the 86th Annual Meeting of the Endocrine Society, New Orleans, LA, p 491 (Abstract P3-109).
- Teichman, Sam L., Neale, Ann, Lawrence, Betty, Gagnon, Catherine, Castaigne, Jean-Paul, & Frohman, Lawrence A. (2006). Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults. https://doi.org/10.1210/jc.2005-1536.
