What is CJC-1295 with DAC?
10December 10, 2022
What is CJC-1295 with DAC?
CJC-1295 With DAC is an exceptionally designed peptide mimicking Growth Hormone Releasing Hormone, acting as a GHRH analogue to cause the anterior pituitary to produce more growth hormone.
CJC-1295 DAC is available in lyophilized powder form and sold in 2 mg vials.
At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy CJC-1295 DAC for sale for research purposes only and not for human consumption.
WHAT IS CJC-1295 with DAC?
CJC-1295 is a synthetically modified and tetra-substituted form of Growth Hormone-Releasing Hormone (GHRH 1-29). These modifications make CJC-1295 a more soluble GH secretagogue, enhancing its stability and effectiveness. The substitution of four amino acids from the core moiety makes CJC-1295 peptide more resistant to cleaving by proteolytic enzymes.
It contains a chain of 30 amino acids, a molecular weight of 3368.7, and molecular formula of C152H252N44O42. CJC-1295 works by binding to serum albumin a, the addition of Drug Affinity Complex or DAC prolongs the half-life of CJC-1295 as well as the duration of action in animal test subjects.
Understanding Drug Affinity Complex: Key Insights into Its Role in CJC-1295 Peptide
Drug Affinity Complex (DAC) increases the half-life of CJC-1295 by binding with serum albumin and preventing its degradation. The addition of DAC helps to slow down kidney excretion. For both in vivo and ex vivo mechanisms, DAC covalently bonds with albumin in order to resist peptide breakdown.
Understanding the Mechanism of Action of CJC-1295 with DAC Peptide for Growth Hormone Release
After administering CJC-1295 DAC on animal test subjects, it reduced the production of the Dipeptidyl Aminopeptidase-IV (DPP-IV) enzyme, thereby enhancing GH release.
DPP-IV is an antigenic enzyme involved in signal transduction, apoptosis or programmed cell death, and immune system regulation. It prolongs the half-life of Growth Hormone (GH) and IGF-1.
CJC-1295 With DAC EFFECTS
CJC-1295 peptide can dramatically increase Growth Hormone, and Insulin-like Growth Factor 1. The effects of which are:
Increased protein synthesis.
Increased bone density
Increase lipolysis
Improves quality of sleep
Increased muscle growth
CJC-1295, like other GHRH analogues, offers several physiological benefits.
Benefits of CJC-1295
CJC-1295 is a growth hormone secretagogue that offers a multitude of benefits, making it a valuable tool in research settings. One of the primary advantages is its ability to significantly increase growth hormone release. This surge in growth hormone is crucial for various physiological processes, including growth, development, and metabolism.
Another notable benefit is the enhancement of protein synthesis. By promoting protein synthesis, CJC-1295 aids in muscle growth and repair, which is essential for maintaining muscle mass and strength. This makes it particularly interesting for studies focused on muscle wasting conditions and recovery.
CJC-1295 also plays a vital role in improving bone density. Increased bone density helps reduce the risk of osteoporosis and fractures, making it a potential candidate for research into bone health and aging.
Moreover, CJC-1295 contributes to better blood sugar regulation. The growth hormone released by CJC-1295 helps maintain stable blood sugar levels, which is crucial for preventing diabetes and other metabolic disorders.
Lastly, CJC-1295 may enhance sperm production, offering a potential avenue for research into male infertility treatments. This multifaceted peptide opens up numerous possibilities for scientific exploration and understanding.
Research Insights into CJC-1295 with DAC
Research has demonstrated that CJC-1295 with DAC is a potent stimulator of growth hormone release. The addition of the drug affinity complex (DAC) significantly enhances the peptide’s stability and half-life, making it a more effective option for addressing growth hormone deficiencies.
One of the key research insights is the increased half-life of CJC-1295 with DAC. The DAC modification allows the peptide to remain active in the body for extended periods, providing sustained stimulation of growth hormone release.
Additionally, the DAC modification improves the bioavailability of CJC-1295. This means that the peptide is more efficiently absorbed and utilized by the body, enhancing its overall effectiveness in stimulating growth hormone release.
CJC-1295 with DAC also exhibits selective receptor affinity. This selective targeting reduces the risk of side effects by focusing on specific receptors in the body, making it a safer option for research purposes.
Furthermore, the prolonged stability provided by the DAC modification makes CJC-1295 with DAC suitable for extended laboratory studies. Researchers can study its effects in greater detail, leading to a deeper understanding of its potential applications and benefits.
CJC-1295 DAC SIDE EFFECTS
Below are what researchers noticed during clinical trials with CJC-1295 DAC’s use in animal test studies. As a soluble GH secretagogue, CJC-1295 DAC has been observed to cause certain side effects during clinical trials.
Anxiety
Irritability
Headaches
Nausea
Precautions When Using CJC-1295 with DAC
While CJC-1295 with DAC is a powerful growth hormone secretagogue, it is crucial to use it with caution. First and foremost, it is important to note that CJC-1295 with DAC is not intended for human consumption and should only be used for laboratory research purposes.
Exogenous administration of CJC-1295 with DAC can lead to unintended consequences, such as insulin resistance and other metabolic disorders. Researchers must be aware of these potential risks and monitor their studies accordingly.
Adhering to the maximum concentration guidelines is essential when using CJC-1295 with DAC. Exceeding the recommended concentration can increase the risk of side effects, compromising the integrity of the research.
It is also important to avoid using CJC-1295 with DAC in combination with other GH secretagogues. Combining multiple GH secretagogues can amplify the risk of adverse effects, making it crucial to use CJC-1295 with DAC in isolation.
Lastly, the lysine linker used in CJC-1295 with DAC can cause allergic reactions in some individuals. Researchers should exercise caution and be vigilant for any signs of allergic responses when using this compound.
By following these precautions, researchers can ensure the safe and effective use of CJC-1295 with DAC in their studies, paving the way for valuable scientific discoveries.
LOOKING FOR WHERE TO BUY CJC-1295 DAC ONLINE
When searching for research peptides online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research, especially when comparing CJC-1295 DAC with other GHRH analogues.
Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy cjc-1295 DAC for sale.
Visit our website or contact us today to buy cjc-1295 DAC online.
References:
Alba, M. et al. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology, Endocrinology, and Metabolism.
Jette, L. et al. (2005). hGRF1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: Identification of CJC-1295 as a long-lasting GRF analog. Endocrinology.
Benquet, C. et al. (2004). (CJC-1295 (DAC-GRF), a long-acting GRF analog, enhances pulsatile GH secretion, increases IGF-I levels, and restores linear growth. Program of the 86th Annual Meeting of the Endocrine Society, New Orleans, LA, p 491 (Abstract P3-109).
Teichman, Sam L., Neale, Ann, Lawrence, Betty, Gagnon, Catherine, Castaigne, Jean-Paul, & Frohman, Lawrence A. (2006). Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults. https://doi.org/10.1210/jc.2005-1536.
