WHAT IS IPAMORELIN?
18September 18, 2022
WHAT IS IPAMORELIN? A Comprehensive Overview of Its Benefits and Uses as a Growth Hormone Releasing Peptide
Ipamorelin is a synthetic growth hormone-releasing peptide that displays potent growth hormone (GH) releasing abilities in animal test subjects. Unlike other GH-releasing peptides, Ipamorelin stimulates the body’s natural production of growth hormone, enhancing muscle growth while minimizing side effects. Additionally, Ipamorelin increases growth hormone levels, benefiting sleep quality, muscle growth, fat metabolism, and overall hormonal balance.
Ipamorelin is available in lyophilized powder form and sold in 2 mg vials. It promotes growth hormone production in a balanced manner, supporting overall health and combating age-related decline.
At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy Ipamorelin for sale for research purposes only and not for human consumption.
WHAT IS IPAMORELIN? A Comprehensive Overview of Its Benefits and Uses
The pentapeptide Ipamorelin, with amino acid sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2, is classified as a GHRP (growth hormone-releasing peptide). It is similar to GHRP-2, GHRP-6, and Hexarelin in stimulating growth hormone (GH) in animal test subjects.
Ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH. It is the mildest alternative to GHRP-2 or GHRP-6 because it does not have as many side effects as other Growth Hormone-Releasing Peptides. Ipamorelin mimics natural hormone-releasing mechanisms to stimulate the growth hormone released, enhancing muscle growth and overall vitality.
Surprisingly, Ipamorelin did not release adrenocorticotropic hormone (ACTH), prolactin, or cortisol at levels significantly different from those observed following GHRH stimulation.
As a member of growth hormone secretagogues, Ipamorelin specifically targets the pituitary gland to promote natural hormone release, unlike synthetic growth hormones that can disrupt hormonal balance.
The specificity of ipamorelin makes it a powerful candidate for future clinical development.
STRUCTURE OF IPAMORELIN
Molecular Formula: C38H49N9O5
Molecular weight: 711.9 g/mol
CAS number: 170851-70-4
IUPAC name: (2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
Іраmоrеlіn behaves like the GН rеlеаѕіng рерtіdе (GНRР) ghrеlіn bу bіndіng tо thе GНRР rесерtоrѕ аnd асtіvаtіng GН rеlеаѕе.
Iраmоrеlіn іѕ mоrе ѕеlесtіvе іn асtіvаtіng the GН ѕуѕtеm, in соntrаѕt tо оthеr соmроundѕ, ѕuсh аѕ GHRP-2 and -6. It іѕ аlѕо mеtаbоlіzеd ѕlоwеr thаn оthеr GНRРѕ, mаkіng іt mоrе ѕtаblе аnd thеrеbу еffесtіvе fоr lоngеr.
HOW IPAMORELIN WORKS
Ipamorelin works by stimulating the pituitary gland to release growth hormone, which in turn promotes the production of insulin-like growth factor-1 (IGF-1). IGF-1 is a protein that plays a crucial role in cell growth and development. By increasing IGF-1 levels, Ipamorelin helps to promote muscle growth, fat loss, and overall health. Unlike other growth hormone releasing peptides (GHRPs), Ipamorelin has a more selective and targeted approach, which reduces the risk of side effects. This selective action ensures that only growth hormone is released, without significantly affecting other hormones like cortisol or prolactin, making it a safer option for research purposes.
OBSERVED EFFECTS OF GROWTH HORMONE RELEASE
Based on available research, the benefits of Iраmоrеlіn may include:
Anti-aging effects
Faster weight loss
Reduced body fat by improving fat metabolism
Increased lean muscle mass growth
Healthy skin, nails, and hair growth
Lowering blood pressure
Less stress and anxiety
Ipamorelin injections not only enhance muscle growth but also significantly promote fat loss by stimulating the release of growth hormones. Higher levels of growth hormone improve the body’s ability to burn fat for energy, aiding in weight management and leading to a leaner, more toned physique, particularly for those experiencing age-related fat gain.
Additionally, Ipamorelin helps increase growth hormone levels safely without causing an imbalance in other hormones. This promotes muscle growth, fat loss, and overall vitality, making it a preferable option over synthetic growth hormone therapies.
COMPARISON TO OTHER PEPTIDES
Ipamorelin is often compared to other growth hormone releasing peptides (GHRPs) such as GHRP-6 and GHRP-2. While all three peptides stimulate growth hormone release, Ipamorelin stands out due to its more selective and targeted approach, which minimizes the risk of side effects. Additionally, Ipamorelin boasts a longer half-life compared to GHRP-6 and GHRP-2, meaning it remains active in the body for extended periods, providing a more sustained release of growth hormone. When compared to Sermorelin, another popular growth hormone releasing peptide, Ipamorelin is considered more effective due to its potent and selective action, making it a preferred choice for researchers.
ADMINISTRATION AND DOSAGE
Ipamorelin is typically examined via subcutaneous administration in laboratory settings, and the testing parameters can vary depending on the research objectives. Studies typically utilize quantities of 200-300 mcg per testing cycle, administered during morning protocols and/or prior to the nocturnal cycle in test subjects. It’s imperative to review relevant scientific literature to determine optimal testing parameters and administration protocols for specific research questions. For enhanced investigational outcomes, research suggests that Ipamorelin can be studied in conjunction with other peptide compounds, such as Sermorelin or CJC-1295. This combination approach may potentially amplify the observed responses, promoting greater growth hormone release in test models and maximizing the potential research findings.
IPAMORELIN OBSERVED RESPONSES
Below are what investigators noted during controlled laboratory investigations with Ipamorelin in animal test studies.
Variations in fluid balance
Sensory alterations
Energy level fluctuations
Changes in glucose response mechanisms
Cranial discomfort
Digestive disturbances
Ipamorelin can exert various influences on biological systems, including potential modulation of growth hormone levels. Comprehensive review of the scientific literature before initiating research is crucial to understand these potential impacts and ensure proper laboratory protocols.
Research suggests that Ipamorelin may stimulate the production and release of growth hormones in test subjects, which appear to play a significant role in muscle tissue development, adipose reduction, and overall hormonal equilibrium, particularly in aging animal models.
Studies indicate that compared to synthetic compounds examined in previous research, Ipamorelin may offer a more measured approach in laboratory investigations by potentially encouraging natural production of growth hormone in test subjects, thereby possibly reducing the observed variations typically documented with synthetic alternatives.
ANTI-AGING AND RECOVERY BENEFITS
Research suggests that Ipamorelin has demonstrated significant anti-aging and recovery potential in laboratory settings. Studies indicate this peptide may improve dermal elasticity, reduce fine lines, and potentially promote increased hair development – contributing to cellular rejuvenation markers. Additionally, research findings point to this compound aiding in adipose tissue reduction, enhancing lean tissue development, and supporting recovery from tissue damage. Laboratory investigations have also noted improvements in sleep architecture, reduced inflammatory markers, and enhanced immune response parameters. By potentially stimulating the body’s natural production of growth hormone, research indicates this peptide may influence cellular aging processes and support overall physiological function in experimental models, making it a compelling substance for anti-aging research protocols.
PRACTICAL CONSIDERATIONS
When examining Ipamorelin in research settings, scientists must consider several practical factors, including research costs, availability for laboratory use, and potential physiological responses. Research suggests this compound is generally well-tolerated in experimental contexts, though investigators have documented occasional reactions including cranial discomfort, energy fluctuations, and balance disturbances in some research subjects. It’s particularly noteworthy that this peptide lacks regulatory approval for therapeutic applications, and its investigation should occur under appropriate scientific supervision. Furthermore, research protocols typically exclude subjects with certain pre-existing conditions such as abnormal cell proliferation, glucose regulation disorders, or thyroid irregularities. Ensuring proper experimental design with appropriate monitoring protocols can help scientists better understand this compound’s mechanisms while maximizing research validity in controlled settings.
LOOKING FOR WHERE TO BUY IPAMORELIN ONLINE
When searching for research peptides online, it is paramount to buy from a trusted laboratory to ensure the integrity of your research.
Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy ipamorelin for sale.
Visit our website or contact us today to buy ipamorelin online.
References:
Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552–561. doi:10.1530/eje.0.1390552
Johansen PB, Nowak J, Skjaerbaek C, et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Horm IGF Res. 1999;9(2):106–113. doi:10.1054/ghir.1999.9998
Andersen NB, Malmlöf K, Johansen PB, Andreassen TT, Ørtoft G, Oxlund H. The growth hormone secretagogue ipamorelin counteracts the glucocorticoid-induced decrease in bone formation of adult rats. Growth Horm IGF Res. 2001;11(5):266–272. doi:10.1054/ghir.2001.0239
