WHAT IS CLENBUTEROL?
Clenbuterol is a medication that was originally developed to treat breathing disorders such as asthma. It works primarily as a bronchodilator to treat asthma by relaxing the bronchial muscles to improve breathing. However, it has gained popularity for its off-label use in weight loss and bodybuilding. Clenbuterol is also used to enhance athletic performance, despite the associated health risks and regulatory concerns. This has led to its controversial status in the world of sports and fitness.
Introduction to Clenbuterol
Clenbuterol is a sympathomimetic amine widely recognized for its dual functionality. Primarily, it serves as a bronchodilator, making it a therapeutic drug approved in some countries for treating respiratory conditions such as asthma. However, its anabolic properties have also garnered attention in the bodybuilding and athletic communities, where it is used as a performance-enhancing drug. Despite its popularity, clenbuterol is not approved for human use by the Food and Drug Administration (FDA) in the United States. Nevertheless, it remains available by prescription in certain countries, highlighting its diverse applications and ongoing interest in its potential benefits.
WHAT IS CLENBUTEROL AS A THERAPEUTIC DRUG APPROVED?
Clenbuterol is a long-acting adrenergic beta-2 receptor agonist primarily used to treat asthma by acting as a bronchodilator, relaxing the bronchial muscles to improve breathing. It is also associated with increased skeletal muscle growth in certain laboratory mammals and has been investigated for its potential treatment application. Clenbuterol for sale is available in liquid form at a concentration of 200mcg per ml at Loti Labs as analytical and research materials. It’s important to note that Clenbuterol is not approved for human use by the Food and Drug Administration (FDA) in the United States.
Research suggests it may increase protein deposition and lipolysis in animal test subjects.
Although it bears structural similarities to other beta-2 agonists and anabolic steroids, studies indicate the effects provided by clenbuterol in research settings are more pronounced and persist for longer durations.
At Loti Labs, we pride ourselves on stocking high-quality research chemicals. Buy clenbuterol for sale for research purposes only and not for human consumption.
WHAT IS CLENBUTEROL?
Clenbuterol is a compound that belongs to a class of beta-2 agonists. It is a sympathomimetic amine and is most commonly available as clenbuterol hydrochloride. In research contexts, clenbuterol has been studied for its bronchodilator properties.
The compound is also known in scientific literature as Spiropent, Dilaterol, and Ventipulmin. Laboratory findings suggest that while it resembles other beta-2 agonists in structure, its observed effects in test settings are more pronounced and long-lasting.
STRUCTURE OF CLENBUTEROL
Molecular formula: C12H18Cl2N2O
Molecular weight: 277.19g/mol
CAS number: 37148-27-9
IUPAC name: 1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol
Clenbuterol is a substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low concentrations in laboratory settings. It shares some structural aspects with other beta-2 receptor compounds. Research indicates that agonism of the beta(2) receptor stimulates adenylyl cyclase activity, which leads to smooth muscle relaxation in the bronchioles of test subjects.
Laboratory research suggests it also promotes cardiac recovery in test subjects with left ventricular assist devices based on viable research studies.
Studies show that aging decreases skeletal muscle mass and strength in test animals. Research suggests that clenbuterol, as a muscle anabolic β2-adrenergic agonist, has reduced or restored skeletal muscle losses in experimental catabolic states, making it a topic of interest in bodybuilding .
Based on research in test subjects, clenbuterol’s excretion out of the body is via urine. For example, when degraded, the compound gets converted to clenbuterol hydroxylamine and NO2-Clenbuterol metabolites via N-oxidation. Research shows that clenbuterol has a half-life of 26 hours and is detected in the blood after 48 hours of administration to test subjects.
Clenbuterol Uses and Benefits
Clenbuterol is a versatile compound with various research applications, including its investigation as a potential performance enhancing substance . Its primary function observed in laboratory settings is as a bronchodilator, with studies suggesting potential benefits for respiratory conditions in test animals.
Research suggests that clenbuterol may have properties that could enhance muscle growth and reduce body fat in laboratory settings. Studies indicate its anabolic properties, although not as pronounced as those of anabolic compounds, may contribute to increased muscle mass and strength in test subjects. Laboratory research suggests clenbuterol’s ability to stimulate thermogenesis and lipolysis, which may increase metabolic rate and fat breakdown in controlled experiments.
Furthermore, clenbuterol has been studied in veterinary research for respiratory conditions in animals, particularly horses. Research into its presence in food-producing animals has raised questions about potential residues, leading to strict regulations and monitoring protocols in many countries.
Comparison to Anabolic Compounds
Clenbuterol is often compared to anabolic compounds in research settings due to observations about its potential anabolic properties. However, it is essential to note that clenbuterol is not a steroid, and research suggests its mechanisms are distinct from those of traditional anabolic compounds used for performance enhancement .
While anabolic compounds operate through specific hormonal pathways, research indicates clenbuterol functions by stimulating beta-2 adrenergic receptors, potentially leading to increased muscle growth and fat reduction in laboratory animals. Studies suggest clenbuterol’s anabolic effects are generally considered milder than those of anabolic compounds in research settings.
Research into clenbuterol has led to its inclusion on the World Anti-Doping Agency’s Prohibited List, highlighting the importance of maintaining its use exclusively for legitimate scientific research and the implications for drug testing .
Clenbuterol Pharmacology
Clenbuterol is a sympathomimetic amine that, according to research, operates by stimulating beta-2 adrenergic receptors. Laboratory studies suggest this stimulation leads to the relaxation of smooth muscles in the airways of test animals, which has implications in veterinary medicine .
Research into clenbuterol’s pharmacokinetics indicates rapid absorption, with peak effects occurring within 2-3 hours of when it is administered in test subjects. Studies suggest its elimination half-life is approximately 36-48 hours, allowing for prolonged observation of effects in research settings.
Laboratory research suggests clenbuterol’s mechanism of action also involves the stimulation of thermogenesis and lipolysis, potentially leading to increased metabolic rate and fat breakdown in test animals.
CLENBUTEROL EFFECTS TO REDUCE BODY FAT
Clenbuterol animal research has shown that it works by increasing the production of noradrenaline and epinephrine, leading to the effects listed below:
Research suggests it causes bronchodilation and decongestion in the upper respiratory tract of animal test subjects.
Laboratory observations indicate increased energy in test subjects.
Studies show increased lipolysis (fat oxidation) in research settings.
Research suggests it is effective in inducing weight loss by increasing body metabolism in test animals.
Laboratory studies indicate it may help in enhancing body strength and retaining muscle mass in test subjects.
Research suggests it can increase muscle mass in laboratory animals.
Clenbuterol Research Observations
Research into clenbuterol has documented various physiological responses, particularly when studied at varying concentrations or for extended periods. Common observations in laboratory settings include tremors, altered heart rates, and increased metabolic activity. These responses are generally attributed to the compound’s stimulation of the sympathetic nervous system in test subjects.
More comprehensive research has examined cardiovascular parameters such as blood pressure regulation, cardiac rhythm, and myocardial function. Long-term laboratory studies have investigated potential adaptive changes in cardiac muscle structure.
Research protocols typically exclude pregnant or lactating animal models due to experimental variables. Laboratory studies often implement additional monitoring for test subjects with pre-existing cardiovascular conditions, altered thyroid function, or glucose metabolism variations.
Clenbuterol Research and Studies
Scientific investigation on clenbuterol has focused on its fundamental mechanisms of action, as well as its various applications in research settings. Studies have examined clenbuterol’s effects on respiratory function in animal models, as well as its potential influence on body composition and metabolic parameters.
However, the majority of research on clenbuterol has been conducted in animal models or in vitro studies, as well as considering its effects in cases of food poisoning . Further research is needed to fully understand clenbuterol’s mechanisms and effects, particularly in more complex physiological systems.
Additionally, studies have highlighted important considerations regarding clenbuterol, including cardiovascular parameters and potential residues in animal-derived products. These findings have informed regulatory frameworks and monitoring protocols in many countries, emphasizing the need for responsible research practices and careful consideration of clenbuterol as a research compound.
CLENBUTEROL PHYSIOLOGICAL RESPONSES AND CARDIOVASCULAR CONSIDERATIONS
Various animal-based findings have revealed that clenbuterol in high concentrations can lead to
Altered stress responses
Increased heart rate
Rapid breathing
Chest discomfort
Tremors
Heart rhythm variations
Electrolyte imbalance
Changes in blood pressure, which should be monitored closely in research settings
Side Effects and Safety
Clenbuterol can induce a range of side effects, particularly when administered in high doses or over extended periods. Commonly reported side effects include increased heart rate, tremors, anxiety, and insomnia. More severe adverse effects can encompass cardiovascular issues such as hypertension, myocardial infarction, and cardiac hypertrophy. Additionally, clenbuterol can cause electrolyte imbalances, further complicating its safety profile. Interactions with other medications, such as beta-blockers and thyroid hormones, can exacerbate these risks, underscoring the importance of cautious use and thorough monitoring in research settings.
Half Life and Dosage
The pharmacokinetics of clenbuterol reveal a half-life of approximately 36-48 hours, indicating that the compound can persist in the body for several days post-administration. For therapeutic purposes, typical dosages range from 20-40 micrograms per day. However, in the context of bodybuilding and athletic performance enhancement, dosages often escalate to 60-120 micrograms per day. It is crucial to note that clenbuterol is not approved for human use in the United States, and its application for performance enhancement is classified as doping, with significant implications for drug testing and regulatory compliance.
Veterinary Medicine and Clenbuterol
In veterinary medicine, clenbuterol is utilized to treat respiratory ailments in animals, particularly horses. Its ability to promote lean muscle mass and reduce body fat has also led to its use in food-producing animals. However, this application raises concerns about food poisoning and the potential for clenbuterol residues in meat products. Consequently, its use is strictly regulated in many countries to ensure food safety. While clenbuterol is approved for veterinary use in some regions, stringent monitoring protocols are in place to mitigate risks and ensure that residues do not enter the human food supply.
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Loti Labs offers affordable prices that come with quality control reports. We have in-depth customer support and a generous return policy when you buy clenbuterol for sale.
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References:
Hinkle RT, Hodge KMB, Cody DB, Sheldon RJ, Kobilka BK, Isfort RJ. Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the β2-adrenergic receptor. Muscle Nerve. 2002;25(5):729-734. https://doi.org/10.1002/mus.10092
MacLennan PA, Edwards RH. Effects of clenbuterol and propranolol on muscle mass. Evidence that clenbuterol stimulates muscle β-adrenoceptors to induce hypertrophy. Biochem J. 1989;264(2):573-579. https://doi.org/10.1042/bj2640573
Petrou M, Wynne DG, Boheler KR, Yacoub MH. Clenbuterol induces hypertrophy of the latissimus dorsi muscle and heart in the rat with molecular and phenotypic changes. Circulation. 1995;92(9):483-489. https://doi.org/10.1161/01.CIR.92.9.483
Thevis M, Geyer L, Geyer H, et al. Adverse analytical findings with clenbuterol among U-17 soccer players attributed to food contamination issues. Drug Test Anal. 2013;5(5):372-376. https://doi.org/10.1002/dta.1471
