TESAMORELIN VS IPAMORELIN
01AprApril 1, 2020
Tesamorelin and Ipamorelin are both synthetic peptides that stimulate the release of growth hormone. However, unlike direct HGH injections, Tesamorelin and Ipamorelin promote natural growth hormone production from the pituitary gland, offering a safer alternative to other growth hormone therapies. This blog post explains what they are, their mechanism of action, their effects, and where you can purchase these USA made peptides.
Understanding Human Growth Hormone
Human growth hormone (HGH) is a vital protein produced by the pituitary gland, playing a crucial role in growth, development, and metabolism. HGH stimulates the production of insulin-like growth factor 1 (IGF-1), which promotes cell growth and division. As we age, HGH levels naturally decline, leading to a decrease in muscle mass, bone density, and metabolic rate. This decline can impact overall health and vitality. Understanding the role of HGH is essential for grasping the benefits and mechanisms of growth hormone peptides like Tesamorelin and Ipamorelin, which aim to boost HGH levels and counteract age-related declines.
What are Growth Hormone Peptides?
Growth hormone peptides are synthetic chains of amino acids designed to mimic the natural growth hormone-releasing hormone (GHRH) or stimulate the release of growth hormone from the pituitary gland. By increasing growth hormone levels, these peptides can enhance muscle growth, improve fat metabolism, and promote overall health. Tesamorelin and Ipamorelin are two popular growth hormone peptides used in peptide therapy to stimulate natural growth hormone release. These peptides help in building muscle mass, reducing body fat, and improving metabolic functions, making them valuable tools in the pursuit of better health and fitness.
WHAT IS TESAMORELIN AND HOW DOES THIS GROWTH HORMONE RELEASING HORMONE WORK?
Tesamorelin is also known as (TH9507). It is a synthetic agonist of growth hormone-releasing factor that stimulates the production and release of endogenous growth hormone. It consists of all 44 amino acids of human GHRH with the addition of a trans-3-hexenoic acid group. It is also potent and more stable than GHRH and is resistant to cleavage by the dipeptidyl aminopeptidase enzyme.
Tesamorelin was found to reduce triglycerides and total cholesterol levels in test subjects with lipodystrophy associated with antiretroviral therapy of HIV infection. Tesamorelin is also being evaluated as therapy of insulin resistance, obesity, and nonalcoholic fatty liver. Additionally, Tesamorelin is effective in reducing visceral fat, highlighting its benefits for individuals with metabolic concerns.
Its empirical formula is C221H366N72O67S, with a molecular weight of 5136 g/mol.
MECHANISM OF ACTION
Tesamorelin activates GHRH receptors in the pituitary, which leads to synthesis and release of growth hormone releasing-hormone that acts on multiple cells of the body, including hepatocytes, where it stimulates the production of insulin-like growth factor-1 (IGF-1). IGF-1 mediates many of the effects of growth hormone, which in the liver include growth, inhibition of programmed cell death, glucose intolerance, and lipolysis. Tesamorelin is part of a class of growth hormone releasing peptides that stimulate growth hormone release from the pituitary gland.
WHAT IS IPAMORELIN, A SELECTIVE GROWTH HORMONE SECRETAGOGUE?
Ipamorelin is a new and potent synthetic pentapeptide which has distinct and specific growth hormone (GH)-releasing properties with potency and efficacy similar to GHRP-6. Ipamorelin stimulates GH release through a GHRP-like receptor. Surprisingly, it does not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation. Making ipamorelin the first GHRH agonist specific for GH release similar to that displayed by GHRH. Ipamorelin is one of the growth hormone releasing peptides known for its benefits in muscle growth and recovery.
Its empirical formula is C38H49N9O5, and the molecular weight is 711.9 g/mol.
MECHANISM OF ACTION
Ipamorelin acts in a completely different way to stimulate growth hormone release. It binds to ghrelin receptors on the pituitary gland with no effect on the rest of the body’s hormones. Ghrelin has profound regulatory effects on metabolism, including increasing or decreasing hunger, inhibiting stored fat breakdown, and most importantly, the release of growth hormone from the pituitary gland.
Reducing Visceral Fat: Tesamorelin and Ipamorelin are effective in reducing visceral fat, which can improve metabolic health and reduce cardiovascular risks.
Benefits of Growth Hormone Peptide Therapy
Growth hormone peptide therapy offers a range of benefits, including:
Increased Muscle Growth and Strength: By boosting growth hormone levels, peptides like Tesamorelin and Ipamorelin promote muscle hypertrophy and enhance physical strength.
Improved Fat Metabolism and Weight Loss: These peptides aid in breaking down fat, leading to more efficient weight management and reduction in body fat.
Enhanced Lean Muscle Mass: Growth hormone peptides support the development of lean muscle, contributing to a more toned and muscular physique.
Improved Bone Density: Higher growth hormone levels can strengthen bones, reducing the risk of fractures and osteoporosis.
Improved Sleep Quality: Better growth hormone levels are associated with deeper, more restorative sleep.
Increased Energy and Endurance: Users often experience higher energy levels and improved stamina.
Improved Overall Health and Well-being: The combined effects of these benefits contribute to a better quality of life.
Growth hormone peptides like Tesamorelin and Ipamorelin can help restore natural growth hormone levels, leading to these significant health improvements.
EFFECTS OF TESAMORELIN AND IPAMORELIN
Tesamorelin and Ipamorelin are two growth hormone peptides that have distinct effects on the body. Tesamorelin is a growth hormone-releasing hormone (GHRH) analog that stimulates the pituitary gland to release growth hormone, leading to increased IGF-1 levels and improved fat metabolism. This results in benefits such as reduced visceral fat and improved lipid profiles. On the other hand, Ipamorelin is a selective growth hormone secretagogue that binds to ghrelin receptors on the pituitary gland, stimulating the release of growth hormone without affecting other hormones. This leads to increased muscle growth, strength, and overall physical performance. Both peptides offer unique advantages, making them valuable tools in growth hormone therapy.
Who Can Benefit from Tesamorelin and Ipamorelin?
Tesamorelin and Ipamorelin can benefit individuals who:
Are experiencing age-related decline in growth hormone levels
Have growth hormone deficiency or insufficiency
Are looking to improve muscle growth and strength
Want to enhance fat metabolism and weight loss
Are seeking to improve overall health and well-being
These peptides can be particularly beneficial for athletes, bodybuilders, and individuals who engage in regular exercise or physical activity. By boosting growth hormone levels, Tesamorelin and Ipamorelin can help these individuals achieve their fitness goals more effectively. However, it’s essential to consult with a healthcare professional before starting any peptide therapy regimen to ensure it is safe and appropriate for your specific needs.
EFFECTS OF TESAMORELIN AND IPAMORELIN ON FAT METABOLISM
Clinical studies show that tesamorelin and ipamorelin peptides don’t affect other pituitary hormones such as thyroid-stimulating hormone (TSH), luteinizing hormone (LH), adrenocorticotropic hormone (ACTH), and prolactin. Both Tesamorelin and Ipamorelin stimulate growth hormone production, leading to various health benefits.
Tesamorelin causes elevated IGF-1 levels, glucose intolerance, hypersensitivity reactions, among others. Ipamorelin’s possible side effects are similar to those of tesamorelin.
Some of the benefits of tesamorelin are related to the breakdown of lipids and triglycerides, which include a reduction in triglyceride levels, visceral adipose tissue, and the size of the carotid blood vessel. The benefits of ipamorelin also include improvement with inflammation, anti-aging properties, and reduced appetite, which leads to faster weight loss.
BUY TESAMORELIN OR IPAMORELIN
Tesamorelin and ipamorelin are available at Loti Labs for your research. We stock the highest quality USA-made peptides that are tested through HPLC and mass spectrometry. Buy peptides from us today!
References:
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Tesamorelin. [Updated 2018 Oct 20]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548730/
Patel A, Gandhi H, Upaganlawar A. Tesamorelin: A hope for ART-induced lipodystrophy. J Pharm Bioallied Sci. 2011;3(2):319–320. doi:10.4103/0975-7406.80763
Fourman LT, Czerwonka N, Feldpausch MN, et al. Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV. AIDS. 2017;31(16):2253–2259. doi:10.1097/QAD.0000000000001614
Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C. Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. J Exp Pharmacol. 2012;4:149–155. Published 2012 Oct 19. doi:10.2147/JEP.S35396
Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552–561. doi:10.1530/eje.0.1390552
Andersen NB, Malmlöf K, Johansen PB, Andreassen TT, Ørtoft G, Oxlund H. The growth hormone secretagogue ipamorelin counteracts the glucocorticoid-induced decrease in bone formation of adult rats. Growth Horm IGF Res. 2001;11(5):266–272. doi:10.1054/ghir.2001.0239
