HEXARELIN VS GHRP-6
Growth hormone-releasing peptides are synthetic peptides that stimulate the release of growth hormones in animal test subjects. Scientists are yet to understand how they work, but they propose a possible dual-site of action on both the pituitary and the hypothalamus, influenced by gh releasing hormone.
Studies show that GHRPs may reduce inflammation because of their antioxidant effects, thereby exhibiting cardioprotective and cytoprotective benefits. This review summarizes the similarities and differences between two hexapeptides, namely: hexarelin and ghrp-6, their mechanism of action, and effects on the release of growth hormone.
Introduction to Growth Hormone
Growth hormone (GH) is a vital hormone produced by the pituitary gland that plays a crucial role in growth, development, and metabolism. GH stimulates the production of insulin-like growth factor-1 (IGF-1), which promotes cell growth and division. This hormone is essential for muscle growth, bone density, and fat metabolism. In adults, GH helps maintain muscle mass, bone density, and overall health, making it a key player in physical well-being and metabolic processes.
Understanding GHRPs
Growth hormone-releasing peptides (GHRPs) are synthetic peptides designed to stimulate the release of growth hormone from the pituitary gland. By binding to specific receptors in the pituitary gland, GHRPs trigger the release of GH, leading to increased levels of this vital hormone. This boost in GH levels can enhance muscle growth, improve recovery, and promote overall health. Among the various types of GHRPs, hexarelin, GHRP-6, and ipamorelin are notable for their unique mechanisms of action and distinct benefits.
HEXARELIN VS GHRP-6: A Comprehensive Comparison of Growth Hormone Releasing Peptides
Hexarelin is a new synthetic growth hormone-releasing peptide (GHRP), which is a synthetic analog of ghrelin (a 28 amino acid peptide) and is closely related to GHRP-6. Human growth hormone (HGH) is crucial for muscle growth and recovery, making it a key focus in bodybuilding and athletic performance. However, it is more stable and more potent than ghrelin. It is a 6 amino acid peptide, with the sequence (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2).
Its empirical formula is C47H58N12O6 and has a molecular weight of 887 g/mol.
Mechanism of Action
GHRPs work by stimulating the release of GH from the pituitary gland. They bind to specific receptors, such as the growth hormone secretagogue receptor (GHS-R), which triggers the release of GH. Additionally, GHRPs stimulate the release of ghrelin, a hormone that regulates appetite and metabolism. The increased GH levels subsequently stimulate the production of IGF-1, promoting cell growth and division. GHRPs also exhibit anti-inflammatory effects, which can help reduce muscle damage and improve recovery.
Comparing Hexarelin and GHRP-6: Key Differences and Benefits
Hexarelin acts through specific receptors at both the pituitary and the hypothalamic level to stimulate growth hormone release in animal test subjects. By increasing GH levels, GHRPs promote the growth and recovery of muscle cells, enhancing overall muscle functionality and protection. It is thought to affect the release of the growth hormone through a phospholipid-dependent protein kinase (PKC) signaling. It mimics the action of ghrelin by binding to the growth hormone secretagogue receptor 1a (GHS-R1a). It also binds to and activates the cardiac receptors CD36.
WHAT IS GHRP-6: How It Stimulates Growth Hormone Release
Growth hormone-releasing peptide-6 is a first-line synthetic hexapeptide and a met-enkephalin derivative that contains a chain of 6 unnatural D amino acids with the sequence (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2).
It was the first hexapeptide studied in animal test subjects and was identified more than a decade ago.
It binds to specific receptors present at the pituitary or hypothalamic level. Studies showed that GHRP-6 receptors are also present in different peripheral tissues such as the heart, adrenal, ovary, testis, lung, and skeletal muscle.
Its empirical formula is C46H56N12O6 and has a molecular weight of 873 g/mol.
Comparing Hexarelin and GHRP-6: Key Differences, Benefits, and Growth Hormone Secretagogue Receptor Interaction
Studies in animal test subjects show that GHRP-6 stimulates ghrelin which increases the production of growth hormone (GH) by acting at the level of the pituitary or hypothalamus through a specific receptor different from that of the endogenous Growth Hormone-Releasing Hormone (GHRH).
The four important parts of the test subjects that demonstrate the role of GHRP-6 include the pituitary gland, central nervous system, liver, and stomach.
EFFECTS OF HEXARELIN AND GHRP-6 ON GROWTH HORMONE RELEASE
The Growth hormone-releasing peptides hexarelin and GHRP-6 have similar effects as seen in animal research with few variations. They both cause weight loss, lean muscle growth, cardioprotection, improved recovery from injuries, etc.
However, hexarelin is rated better than GHRP-6 because it easily stimulates the secretion of GH, ACTH (adrenocorticotropic hormone), cortisol, and prolactin even during sleep. But plasma glucose, luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone, and insulin-like growth factor-1 are not affected by hexarelin administration. It also doesn’t cause an increase in ghrelin like GHRP-6. Its half-life is longer than that of GHRP-6.
Muscle Growth and Recovery
GHRPs have been shown to significantly improve muscle growth and recovery by increasing GH levels. GH stimulates the production of IGF-1, which promotes muscle cell growth and division. Additionally, GHRPs help reduce muscle damage and inflammation, further enhancing muscle recovery. This is achieved through the stimulation of GH, which has anti-inflammatory effects. Moreover, GHRPs can improve muscle protein synthesis, leading to increased muscle mass and strength.
Cortisol Responses and GH Release
Cortisol, a hormone produced by the adrenal gland, regulates stress response and metabolism. Elevated cortisol levels can suppress GH release, negatively impacting muscle growth and recovery. GHRPs have been shown to reduce cortisol levels, thereby increasing GH release. This reduction in cortisol is achieved through the anti-inflammatory effects of GH. Additionally, GHRPs can improve sleep quality, which is essential for optimal GH release and muscle recovery. By mitigating the adverse effects of cortisol, GHRPs support better muscle growth and overall health.
CONCLUSION
The growing interest in GHRPs has evolved in recent times because they are better at increasing plasma GH levels in a physiologically pulsatile manner in animals. So whatever your choice is between hexarelin or GHRP-6, Loti Labs assures you of the highest quality USA-made peptides which are tested through HPLC and mass spectrometry. Buy peptides from us today!
References:
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Bellone J, Bartolotta E, Sgattoni C, et al. Hexarelin, a synthetic GH-releasing peptide, is a powerful stimulus of GH secretion in pubertal children and adults but not in prepubertal children and elderly subjects. J Endocrinol Invest. 1998;21(8):494–500. doi:10.1007/BF03347334
Arvat E, Ramunni J, Bellone J, et al. The GH, prolactin, ACTH, and cortisol responses to Hexarelin, a synthetic hexapeptide, undergo different age-related variations. Eur J Endocrinol. 1997;137(6):635–642. doi:10.1530/eje.0.1370635
Settembrini B, Figueroa J, Gallardo M, Chiocchio S. Growth Hormone (GH) but not IGF-I-Secretion is Stimulated in Aged Rats by Chronic Hexarelin and GHRP-6 administration. Endocr Regul. 1998;32(1):17–26.
Bresson-Bepoldin L, Dufy-Barbe L. GHRP6-stimulated hormone secretion in somatotrophs: involvement of intracellular and extracellular calcium sources. J Neuroendocrinol. 1996;8(4):309–314. doi:10.1046/j.1365-2826.1996.04608.x
