Tesamorelin – A Novel GHRH | Buy Tesamorelin
09March 9, 2020
Tesamorelin – A Novel Growth Hormone Releasing Hormone | Buy Tesamorelin
Tesamorelin is a peptide that deserves mention because of its implication in the management of HIV. Studies show that it could reduce cardiovascular diseases in HIV infected test subjects.
In November 2010, tesamorelin was approved by the US Food and Drug Administration for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy, effectively helping to reduce excess fat associated with the condition. This condition happens as a result of the HIV infection itself and antiretroviral therapy. It is sold under the trade name Egrifta.
Tesamorelin is sold at Loti Labs for research purposes only and isn’t formulated for human consumption. We go to great lengths to provide exceptionally high-quality products to our customers as a USA based peptide and research company.
In this article, we will discuss the tesamorelin peptide, what it is, its effects and where to buy this peptide.
[WHAT IS TESAMORELIN AND INJECTION SITE REACTIONS](https://lotilabs.com/peptides/buy-tesamorelin-2mg.html)
Tesamorelin is also known as (TH9507). It is a synthetic agonist of growth hormone-releasing factor that stimulates the production and release of endogenous growth hormone, thereby enhancing growth hormone production. It consists of all 44 amino acids of human GHRH with the addition of a trans-3-hexenoic acid group. It is also potent and more stable than GHRH and is resistant to cleavage by the dipeptidyl aminopeptidase enzyme.
When tested in animals, it significantly reduced visceral adipose tissue (VAT). Tesamorelin was found to reduce triglycerides and total cholesterol levels in test subjects with lipodystrophy associated with antiretroviral therapy of HIV infection. Tesamorelin is also being evaluated as therapy of insulin resistance, obesity, and nonalcoholic fatty liver. Unlike recombinant human growth hormone, Tesamorelin has shown a favorable safety profile with fewer liver-related adverse events in studies.
STRUCTURE OF TESAMORELIN AND ITS IMPACT ON BODY COMPOSITION
Sequence:Unk-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
Molecular Formula: C221H366N72O67S
Molecular weight: 5136 g/molS
CAS number: 804475-66-9
MECHANISM OF ACTION ON VISCERAL ADIPOSE TISSUE
Tesamorelin activates GHRH receptors in the pituitary gland, which leads to the synthesis and release of growth hormone-releasing hormone that acts on multiple cells of the body, including hepatocytes, where it stimulates the production of insulin-like growth factor-1 (IGF-1). IGF-1 mediates many of the effects of growth hormone, which in the liver include growth, inhibition of programmed cell death, glucose intolerance, and lipolysis.
Studies show that tesamorelin’s main mechanism of action is through lipolysis. Lipolysis is the breakdown of lipids and triglycerides, which are both fats that are found in the body. Generally, lipids and triglycerides are stored in the body to be used later for energy. However, a high level of either can increase the risk of heart disease.
BENEFITS OF TESAMORELIN
Tesamorelin offers a multitude of benefits for those aiming to enhance their body composition and overall health. One of the most significant advantages is its ability to reduce excess visceral adipose tissue. This type of fat, which accumulates around the organs in the abdominal cavity, is linked to various metabolic concerns, including cardiovascular disease and insulin resistance. By targeting and decreasing visceral fat, tesamorelin helps mitigate these risks.
In addition to reducing visceral fat, tesamorelin is known to improve overall body composition. It achieves this by not only decreasing fat mass but also increasing lean body mass. This dual action makes it a valuable tool for those looking to achieve a healthier, more balanced physique.
Another critical benefit of tesamorelin is its support for cardiovascular health. By reducing visceral fat and enhancing insulin sensitivity, it helps lower the risk of heart disease. This makes it particularly beneficial for individuals with metabolic concerns.
Moreover, tesamorelin promotes muscle growth and increases muscle mass. This can lead to improved strength, fitness, and overall health. Its ability to enhance metabolic health by reducing insulin resistance and improving glucose metabolism further underscores its potential as a comprehensive health booster.
WHO IS A GOOD CANDIDATE FOR TESAMORELIN?
Tesamorelin is particularly beneficial for individuals struggling with excess visceral adipose tissue. This type of fat is not just a cosmetic concern; it poses significant health risks, especially when it accumulates around the organs in the abdominal cavity. Good candidates for tesamorelin treatment include:
Individuals with Human Immunodeficiency Virus (HIV): Those experiencing lipodystrophy, a condition characterized by abnormal fat distribution due to HIV infection and antiretroviral therapy, can benefit significantly from tesamorelin.
Individuals with Excess Abdominal Fat: Those with a high waist circumference and excess abdominal fat are ideal candidates. Tesamorelin can help reduce this stubborn fat, improving both appearance and health.
Individuals with Metabolic Concerns: Those dealing with insulin resistance, cardiovascular disease, or other metabolic issues can find tesamorelin beneficial. Its ability to improve insulin sensitivity and support cardiovascular health makes it a valuable treatment option.
Individuals Looking to Improve Body Composition: Anyone aiming to enhance their body composition by reducing fat mass and increasing lean body mass can benefit from tesamorelin.
ADMINISTRATION AND DOSAGE
Tesamorelin is typically administered via subcutaneous injection, making it a convenient option for many users. The recommended dosage is generally 2 mg per day, delivered through a subcutaneous injection. It’s crucial to adhere to this dosage and follow the administration instructions carefully to achieve the best results and minimize potential side effects.
For optimal outcomes, it’s essential to consult with a healthcare provider who can tailor the dosage to individual needs and monitor progress. This ensures that the treatment is both safe and effective, helping users achieve their health and fitness goals.
POTENTIAL SIDE EFFECTS AND INTERACTIONS
Like any medication, tesamorelin may cause potential side effects and interactions. Common side effects include injection site reactions such as redness, swelling, and pain. These are typically mild and resolve on their own. However, it’s important to be aware of other potential effects on glucose metabolism, such as increased blood sugar levels, which may require monitoring and management.
Other possible side effects include headache, fatigue, and dizziness. While these are generally mild, it’s essential to monitor them and consult with a healthcare provider if they persist or worsen.
Tesamorelin may also interact with other medications, particularly insulin and oral hypoglycemic agents. Therefore, it’s crucial to inform your healthcare provider of all medications you are taking to avoid adverse interactions. Additionally, tesamorelin may not be suitable for individuals with certain medical conditions, such as cancer or benign or malignant tumors. Regular follow-up appointments with a healthcare provider can help ensure the treatment’s safety and efficacy, allowing for adjustments as needed.
LOOKING FOR WHERE TO BUY PEPTIDES
Tesamorelin can be purchased from Loti Labs. It is important to buy peptides which are USA-made to ensure the integrity of your research. Tesamorelin sold from Loti Labs is tested through HPLC and Mass spectrometry to ensure quality. Tesamorelin is commonly sold in 2mg vials. It is available in lyophilized powder form.
References
National Center for Biotechnology Information. PubChem Database. Tesamorelin, CID=16137828, https://pubchem.ncbi.nlm.nih.gov/compound/Tesamorelin (accessed on Mar. 4, 2020)
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Tesamorelin. [Updated 2018 Oct 20]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548730/
Knoop, Andre et al. “Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS.” Analytical and bioanalytical chemistry vol. 408,12 (2016): 3145-53. doi:10.1007/s00216-016-9377-3
Patel A, Gandhi H, Upaganlawar A. Tesamorelin: A hope for ART-induced lipodystrophy. J Pharm Bioallied Sci. 2011;3(2):319–320. doi:10.4103/0975-7406.80763
Fourman LT, Czerwonka N, Feldpausch MN, et al. Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV. AIDS. 2017;31(16):2253–2259. doi:10.1097/QAD.0000000000001614
