IPAMORELIN vs GHRP-6

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04Feb

IPAMORELIN vs GHRP-6

By Peptides

04FebFebruary 4, 2020

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In this article, we will review the growth hormone-releasing peptides ipamorelin and GHRP-6. They have many similarities and a few differences. We aim to help you decide which peptide you need for your research. They are both available for sale at Loti Labs, which is a USA based peptide and research company.

A BRIEF INTRODUCTION OF GROWTH HORMONE RELEASING PEPTIDES

Growth hormone-releasing peptides GHRPs are synthetic, non-natural peptides equipped with potent stimulatory effects on Growth hormone secretion in animal test subjects. They have no structural resemblance with Growth Hormone-Releasing Hormone and act through specific receptors present either at the pituitary or hypothalamic level in animals. Unlike GHRPs, growth hormone releasing hormones do not share structural similarities with GHRPs and may work through different mechanisms at the pituitary or hypothalamic level. The GH-releasing activity of GHRPs is noticeable and dose-related after intravenous subcutaneous intranasal and oral administration.

The Growth Hormone Releasing Peptides are affected by glucose, free fatty acids, glucocorticoids, and somatostatin.

Ipamorelin is a third-generation GHRP after GHRP-6, which belongs to the first generation to be extensively studied in animals. It is similar to GHRP-6 because they both release GH at similar rates without the side effects that GHRP-6 exhibits. GHRP-6 causes a release, and an increase in cortisol and prolactin levels, however, ipamorelin only selectively releases GH.

STRUCTURAL DIFFERENCES BETWEEN GHRP6 AND IPAMORELIN

DIFFERENCES

GHRP 6

IPAMORELIN

STRUCTURE

Comparison of Ipamorelin and GHRP-6 peptides showing their roles in growth hormone research.
Comparison chart of Ipamorelin and GHRP-6, highlighting their structures and growth hormone-releasing effects.

AMINO ACID SEQUENCE

His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

H-Aib-His-D-2Nal-D-Phe-Lys-NH2

MOLECULAR FORMULA

C46H56N12O6

C38H49N9O5

MOLECULAR WEIGHT

873 g/mol

711.9 g/mol

Understanding the Mechanism of Action for Ipamorelin and GHRP-6 via the Growth Hormone Secretagogue Receptor

Studies in animal test subjects show that both GHRP-6 and ipamorelin stimulate Ghrelin, “the hunger hormone” through its ghrelin receptor which in turn signal an increased production of growth hormone (GH) by acting at the level of the pituitary or hypothalamus through a specific receptor different from that of the endogenous Growth Hormone-Releasing Hormone GHRH. This specific receptor is known as the growth hormone secretagogue receptor (GHS-R). The effects of GHRP-6 on GH release were achieved using various doses and administration routes.

Іn соntrаѕt tо GHRP-6, Iраmоrеlіn іѕ mоrе ѕеlесtіvе іn іtѕ асtіvаtіоn because it doesn’t have any effect on cortisol or prolactin. It іѕ mеtаbоlіzеd ѕlоwеr thаn GHRP-6, mаkіng іt mоrе ѕtаblе аnd thеrеbу еffесtіvе fоr lоngеr.

Benefits and Effects of Ipamorelin

Ipamorelin is a potent growth hormone-releasing peptide (GHRP) that offers several notable benefits and effects:

  1. Enhanced Muscle Growth: Ipamorelin stimulates the release of growth hormone, which promotes muscle growth and development. This makes it a valuable tool for researchers studying muscle hypertrophy and skeletal muscle adaptation.

  2. Improved Recovery: By enhancing growth hormone release, Ipamorelin helps improve recovery times after exercise. This allows athletes and test subjects to train more frequently and with greater intensity, facilitating better performance and muscle growth.

  3. Increased Bone Density: Research indicates that Ipamorelin can increase bone density, which is crucial for reducing the risk of osteoporosis and fractures. This effect is particularly beneficial in studies focused on bone health and aging.

  4. Improved Sleep Quality: Ipamorelin has been shown to improve sleep quality, which is essential for muscle recovery and overall well-being. Better sleep contributes to enhanced muscle growth and cognitive function.

  5. Enhanced Skin Elasticity: Ipamorelin has also been shown to improve skin elasticity, reducing the appearance of fine lines and wrinkles. This makes it a subject of interest in studies related to aging and dermatology.

COMPARING AND CONTRASTING THE EFFECTS OF IPAMORELIN AND GHRP-6 TO ENHANCE MUSCLE GROWTH

Ipamorelin and GHRP-6 have similar effects on animal test subjects but differ structurally. They both act on the pituitary gland to release growth hormone. The release of growth hormone by these peptides can lead to increases in lean body mass, which is beneficial for body composition. Their differences are listed in the table below.

GHRP-6

IPAMORELIN

Effect on hunger

Increases hunger markedly

Doesn’t promote hunger

Effect on growth hormone release

More

Less

Effect on prolactin and cortisol release

Less control

None observed

Potency

Same

Same

Half-life

Shorter half-life

Longer half-life

Potential Side Effects and Mitigation Strategies

While Ipamorelin and GHRP-6 are generally well-tolerated, potential side effects may include:

  1. Headaches: Some test subjects may experience headaches due to the stimulation of growth hormone release. This can be managed by adjusting the dosage or administration schedule.

  2. Joint Pain: Increased growth hormone levels can sometimes lead to joint pain. Monitoring and adjusting the dosage can help mitigate this side effect.

  3. Fatigue: The increased energy expenditure associated with growth hormone release may cause fatigue. Ensuring adequate rest and recovery can help manage this symptom.

  4. Nausea: Nausea may occur due to the stimulation of growth hormone release. Gradually increasing the dosage can help the body adjust and reduce this side effect.

To mitigate these side effects, it is recommended to:

  1. Start with a Low Dose: Begin with a low dose and gradually increase as needed. This allows the body to adjust and reduces the risk of adverse effects.

  2. Cycle the Peptides: Cycling the peptides can help avoid desensitization and reduce the risk of side effects. This involves taking breaks between cycles of peptide administration.

  3. Monitor Blood Work: Regularly monitor blood work to ensure that growth hormone levels remain within a healthy range. This helps in identifying any potential issues early on.

  4. Consult a Healthcare Professional: Before starting any peptide therapy, it is crucial to consult a healthcare professional. They can provide personalized advice and ensure that the therapy is safe and effective.

By following these strategies, researchers can maximize the benefits of Ipamorelin and GHRP-6 while minimizing potential side effects, ensuring the integrity and success of their studies.

Conclusion: Key Insights on Ipamorelin vs. GHRP-6 Peptides

GHRP-6 is one of the first GHRPs synthesized, and is widely considered to be the most effective of the growth hormone-releasing peptides, but the choice between GHRP-6 and ipamorelin depends on the outcome you want to achieve. Whatever your choice is, Loti Labs assures you of the highest quality USA-made peptides.

LOOKING FOR WHERE TO BUY RESEARCH PEPTIDES?

Ipamorelin and GHRP-6 can both be purchased from Loti Labs. These peptides are considered research peptides, which are used in scientific studies to explore their effects on growth hormone stimulation and other bodily functions. It is important to buy peptides that are USA-made for the integrity of your research. Ipamorelin and GHRP-6 sold from Loti Labs are tested through HPLC and Mass spectrometry to ensure quality. Ipamorelin and GHRP-6 are available in lyophilized powder form in 2mg and 5mg vials, respectively. Buy your peptides from is today!

References:

  1. Camanni, Franco & Ghigo, Ezio & Arvat, Emanuela. (1998). Growth Hormone-Releasing Peptides and Their Analogs. Frontiers in neuroendocrinology. 19. 47-72. 10.1006/frne.1997.0158.

  2. Wu D, Chen C, Zhang J, Bowers CY, Clarke IJ. The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3′,5′-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs. J Endocrinol. 1996;148(2):197–205. doi:10.1677/joe.0.1480197

  3. Rogério G. Gondo, Manuel H. Aguiar-Oliveira, César Y. Hayashida, Sergio P. A. Toledo, Neusa Abelin, Michael A. Levine, Cyril Y. Bowers, Anita H. O. Souza, Rossana M. C. Pereira, Norma L. Santos, Roberto Salvatori, Growth Hormone-Releasing Peptide-2 Stimulates GH Secretion in GH-Deficient Patients with Mutated GH-Releasing Hormone Receptor, The Journal of Clinical Endocrinology & Metabolism, Volume 86, Issue 7, 1 July 2001, Pages 3279–3283, https://doi.org/10.1210/jcem.86.7.7694

  4. Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552–561. doi:10.1530/eje.0.1390552

  5. Johansen PB, Nowak J, Skjaerbaek C, et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Horm IGF Res. 1999;9(2):106–113. doi:10.1054/ghir.1999.9998

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