Triptorelin Review | Buy Triptorelin GnRH Peptide
Triptorelin Review | Buy Triptorelin Gonadotropin Releasing Hormone Agonist Peptide
Comprehensive Guide to Triptorelin Peptide: Uses and Benefits
Triptorelin, a GnRH agonist, is known to inhibit the release of estrogen and induce a profound hypogonadism, often referred to as “chemical castration” in animal test subjects. Research suggests it could be utilized predominantly as an androgen deprivation approach in studies of advanced prostate cancer. Triptorelin acetate, a synthetic peptide, is also explored in research for hormone-responsive conditions. Studies indicate its potential in addressing benign conditions responsive to hormonal modulation such as endometriosis, uterine fibroids, precocious puberty, and infertility. However, in lower administrations, GnRH or triptorelin may exhibit the reverse effect on the HPTA, potentially stimulating FSH and LH. Triptorelin is not intended for diagnostic or therapeutic procedures.
If you are looking for where to buy triptorelin for your research, we have it stocked at Loti Labs. This peptide is of the highest purity and we can guarantee a 100% satisfaction or your money back.
WHAT IS TRIPTORELIN ACETATE?
Triptorelin is also known as 6-D-Tryptophan. It is a synthetic analogue and gonadotropin releasing hormone agonist of the naturally occurring Gonadotropin-releasing hormone produced in the hypothalamus. It interacts with Gonadotropin-releasing hormone receptors in the pituitary gland, stimulating the release of Luteinizing hormone (LH) and Follicular stimulating hormone (FSH), which are involved in the production and release of testosterone by the male testes and estrogen by the female ovaries and placenta. It is a decapeptide containing the amino acids in the sequence H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2. It is considered a more potent form of GnRH.
Animal studies comparing triptorelin to native GnRH found that triptorelin had 13-fold higher releasing activity for luteinizing hormone, and 21-fold higher releasing activity for follicle-stimulating hormone. The differences in amino acid composition between Triptorelin and the native molecule enhance its functionality, providing extended plasma half-life and increased agonistic effects.
STRUCTURE OF TRIPTORELIN
Sequence: H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
Molecular Formula: C64H82N18O13
Molecular weight: 1311.4 g/mol
CAS number: 57773-63-4
MECHANISM OF ACTION: Pituitary Secretion
Triptorelin demonstrates a strong affinity for Gonadotropin-Releasing Hormone Receptor compared to native GnRH. Upon binding to receptors on gonadotropes following intravenous administration, it induces gonadotropin release (flare-up effect). After several days, this is followed by a significant reduction in the circulating concentrations of FSH and LH, through a desensitization mechanism, which suggests a decline in testosterone and estrogen synthesis. This reduction in pituitary secretion is crucial as triptorelin controls the release of key hormones such as Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH).
The metabolism of triptorelin is not well understood; however, metabolism likely does not involve hepatic enzymes such as cytochrome P450. Triptorelin has no identified metabolites. It is eliminated through the kidneys and the liver and has a strong resistance to enzymatic breakdown and a prolonged half-life of 3 hours compared to native GnRH of about 2 to 4 minutes. This extended plasma half-life is crucial for understanding the compound’s effectiveness and its impact on hormone regulation.
Comprehensive Overview of Triptorelin Uses in Research and Therapy for Prostate Cancer
Circulating levels of testosterone in male test subjects and estrogen in female test subjects regulate the synthesis of GnRH, which is typically produced in a pulsatile manner. Triptorelin, a GnRH agonist, infusions may produce a transient increase in sex hormones, but with continued non-pulsatile stimulation, gonadotropins luteinizing hormone (LH) and FSH synthesis are inhibited, potentially causing a decline in estrogen and testosterone levels. Research suggests that triptorelin’s effects are due to this phenomenon. Triptorelin, like other GnRH agonists, is explored in studies for hormone-responsive conditions and other areas. Below are its research applications:
Palliation of prostate cancer in test subjects
Chemical castration in research environments
Studying endometriosis
Exploration in breast cancer research
Investigating precocious puberty in male rats
Handling and Storage Considerations
Proper handling and storage of triptorelin are crucial to maintaining its stability and potency in research settings. Here are some key considerations:
LOOKING FOR WHERE TO BUY PEPTIDES
You can purchase triptorelin from Loti Labs. Buy peptides which are USA-made for the integrity of your research. It is tested through HPLC and Mass spectrometry to ensure quality. Triptorelin is commonly sold in 100mcg vials and is available in lyophilized powder form.
References
National Center for Biotechnology Information. PubChem Database. Triptorelin, CID=25074470, https://pubchem.ncbi.nlm.nih.gov/compound/Triptorelin (accessed on Dec. 20, 2019)
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): the National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Triptorelin. [Updated 2018 Mar 22]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548756/
Merseburger, A.S. & Hupe, M.C. Adv Ther (2016) 33: 1072. https://doi.org/10.1007/s12325-016-0351-4
Leschek EW, Flor AC, Bryant JC, Jones JV, Barnes KM, Cutler GB Jr. Effect of Antiandrogen, Aromatase Inhibitor, and Gonadotropin-releasing Hormone Analog on Adult Height in Familial Male Precocious Puberty. J Pediatr. 2017;190:229–235. doi:10.1016/j.jpeds.2017.07.047
