Testolone Review | Buy RAD-140 Testolone Sarms
29December 29, 2019
Testolone Review | Buy RAD-140 Testolone Sarms
What is RAD-140? A Selective Androgen Receptor Modulator
Commonly sold as Testolone, RAD-140 is among the most popular selective androgen receptor modulators or SARMs. Being a SARM, it is different in its approach to muscle building than prohormones because of which it is considered to be safer and more effective. It is also called Testolone because it mimics the action of testosterone. RAD-140 is being explored as an alternative to traditional androgen therapy due to its selective action on androgen receptors.
RAD-140 Molecular Structure
Molecular Formula: C20H16ClN5O2
Molecular Weight: 393.8 g/mol
What is RAD-140 Testolone? A Comprehensive Overview
RAD-140 is a powerful compound and is known for providing quick results in research subjects. As soon as RAD-140 is consumed, its molecules dissolve and bind with the androgen receptors that are located in or near the muscle tissues and bones. RAD-140 is effective in promoting muscle growth, particularly in treating muscle wasting diseases such as sarcopenia and cachexia. It then mimics the action of testosterone which results in high nitrogen retention in the body. This, in turn, boosts protein synthesis and ultimately delivers faster muscle growth.
The tissue-specific effects of RAD-140 are another reason why it is so popular. It selectively targets muscle and bone tissues while sparing other organs, reducing the risk of side effects. However, RAD-140 has been shown to have limited benefits on skeletal muscle adaptation in some studies, increasing frailty and mortality risk while failing to enhance muscle strength or adaptive potential. This makes it a safer alternative to traditional anabolic steroids.
Mechanism of Action and Tissue-Specific Effects
RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM) that works by selectively targeting androgen receptors in muscle and bone tissues. This selective binding triggers anabolic activity, leading to increased muscle mass and strength. Unlike traditional anabolic steroids, RAD-140 does not convert to estrogen, thereby reducing the risk of estrogen-related side effects such as gynecomastia.
RAD-140’s mechanism of action involves the activation of androgen receptors in muscle and bone tissues, which leads to the promotion of muscle growth and bone density. This is achieved through the stimulation of protein synthesis and the inhibition of protein degradation, resulting in increased lean body mass and muscle strength.
The tissue-specific effects of RAD-140 are due to its ability to selectively target androgen receptors in muscle and bone tissues, while avoiding the prostate and other reproductive tissues. This makes RAD-140 a potential treatment for muscle wasting diseases and osteoporosis, as it can promote muscle growth and bone density without the risk of prostate-related side effects.
Research Related to RAD-140: Preclinical and Clinical Development
RAD-140 is one of the newest members of SARM and is still undergoing research trials.
In February 2011, the research concluded that RAD-140 improves lean muscle mass by accurately targeting androgen receptors that are present in skeletal tissues. (Reference 1)
One of the criticisms SARMs face is we still don’t know much about their effects on our brain. But in the case of RAD-140, research indicates that it doesn’t have any negative effects, particularly on brain tissues. Thus, Testolone is classified as neuroprotective. It can reduce cell deaths which are induced by apoptotic insults, thus contributing to brain cell growth. (Reference 2)
Please note that most, if not all, of the studies, are conducted on rats. Studies on female mice have shown increased frailty and mortality risk with long-term RAD-140 supplementation.
The first-in- trial of RAD-140 for effects on breast cancer for postmenopausal women is being conducted and the results will be out in December of 2020. (Reference 3)
Neuroprotective Effects of RAD-140
RAD-140 has been shown to have neuroprotective effects in preclinical studies, particularly in the context of Alzheimer’s disease and other neurodegenerative disorders. The neuroprotective effects of RAD-140 are thought to be mediated by its ability to activate androgen receptors in the brain, which leads to the stimulation of neuroprotective pathways.
RAD-140 has been shown to increase cell viability and reduce apoptosis in neuronal cultures, and has also been shown to reduce the levels of beta-amyloid, a protein that is associated with Alzheimer’s disease. Additionally, RAD-140 has been shown to improve cognitive function and reduce the severity of neurodegenerative symptoms in animal models of Alzheimer’s disease.
The neuroprotective effects of RAD-140 are thought to be due to its ability to activate the MAPK/ERK signaling pathway, which is involved in the regulation of neuronal survival and function. RAD-140 has also been shown to increase the levels of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), which are involved in the regulation of neuronal survival and function.
Overall, the neuroprotective effects of RAD-140 make it a potential treatment for neurodegenerative disorders, particularly Alzheimer’s disease. However, further research is needed to fully understand the mechanisms of action and potential therapeutic applications of RAD-140 in the context of neuroprotection.
RAD-140 Uses for Promoting Muscle Growth
Initially, Testolone was developed to treat hypogonadism, but it never came out to the public. But now it is being shown to have promise as a muscle growth compound. While developing muscle mass and strength, it also helps in bringing about weight loss.
Besides that, Testolone finds its usage in the cure for breast cancer and preventing muscle wasting. RAD-140 has also been shown to have an energizing effect for test subjects engaging in high intensity muscle building activities.
RAD-140 Effects on Increased Muscle Mass
Although SARMs, in general have been shown to be relatively safe, trials are still on going and much is still unknown. The higher the doses given to the rat test subjects, the higher are the chances of developing side effects. The safe dose shown of RAD-140 is about 0.1mg/kg. So, a 1 kg rat can safely consume 0.1 mg per day.
RAD-140 for Sale
RAD-140 is available online and in stores for purchase. However RAD-140 is not approved for human use and should only be handled by qualified professionals. Buy RAD-140 Testolone from Loti Labs to get the purest form of the compound for effective research and studies.
Buy RAD-40 today.
Reference 1: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018048/
Reference 2: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959610/
Reference 3: https://clinicaltrials.gov/ct2/show/NCT03088527
