WHAT IS IGF-1 LR3 and Review
What is IGF-1 LR3?
IGF-1 LR3 is a synthetic variant of the naturally occurring insulin-like growth factor-1 (IGF-1), a hormone integral to growth and development. Unlike its natural form, IGF-1 LR3 is engineered to have a longer half-life, thereby extending its effectiveness within the body. This prolonged duration is attributed to its structure of 83 amino acids, which enhances its bioavailability and potency. While IGF-1 is mainly produced in the liver, IGF-1 LR3 is synthesized in various tissues throughout the body, making it a versatile and potent agent for promoting growth and development. The modifications in IGF-1 LR3 ensure it remains active in the body for an extended period, providing ongoing benefits.
Research suggests that IGF-1 LR3’s extended half-life allows it to remain active in the bloodstream for approximately 20-30 hours, significantly longer than the natural IGF-1’s 12-15 hours. This longer duration may enhance its ability to promote muscle growth, repair, and recovery more effectively. As a result, it is often explored by researchers studying muscle gains and performance improvement. The peptide’s potential to stimulate protein synthesis and inhibit protein breakdown further contributes to its potent anabolic effects, which may aid in the development of lean muscle mass and the reduction of body fat.
Moreover, IGF-1 LR3’s influence extends beyond muscle-building. Research suggests it plays a crucial role in cellular repair and regeneration, supporting the recovery of damaged muscle tissue and potentially aiding in the healing of injuries. Its impact on glucose uptake and metabolic processes also highlights its potential benefits for individuals with insulin resistance or those seeking to optimize their metabolic health. Despite its promising advantages, it is essential to approach IGF-1 LR3 usage with caution, adhering to recommended guidelines and consulting healthcare professionals to mitigate potential risks.
IGF-1 LR3 Review for Muscle Mass | Buy IGF-1 LR3
Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue insulin-like growth factor 1 (IGF-1). It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence (“arginine 3”), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) (“long”), for a total of 83 amino acids (relative to the 70 of IGF-1). IGF-1 LR3 amounts may depend on individual characteristics such as body weight and fitness goals.
The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability. As a result, it is approximately three times more potent than IGF-1 and possesses a significantly longer half-life of about 20–30 hours (relative to IGF-1’s half-life of about 12–15 hours). It is a sterile filtered white lyophilized (freeze-dried) powder. Additionally, there is a relationship between body mass index (BMI) and IGF-1 levels, and maintaining a healthy weight may positively affect IGF-1 levels.
IGF-1 Long R3, or IGF-1 LR3, is a form of IGF that has been chemically altered with changed amino acids. It consists of 83 amino acids with a substitution of Arg(R) for the Glu(E) at position three, hence, the name R3. These alterations enable it to avoid binding to proteins in the body, which allows it to have a longer half-life.
Understanding the Mechanism of Action of Insulin Like Growth Factor IGF-1 LR3
IGF-1 LR3 (Insulin-like growth factor-1 LR3) is a major hormonal mediator of statural growth. Under regular circumstances, GH (growth hormone) binds to its receptor in the liver, and other tissues, and stimulates the synthesis/secretion of IGF-1. In target tissues, the type 1 IGF receptor, which is homologous to the insulin receptor, is activated by IGF-1 LR3 leading to intracellular signaling which stimulates multiple processes leading to statural growth. IGF-1 LR3 supports cell growth and differentiation, particularly in muscle cells.
IGF-1 LR3 metabolic actions are partly directed at stimulating the uptake of glucose, fatty acids, and amino acids so that metabolism supports growing tissues. The insulin growth factor plays a crucial role in enhancing physical performance and metabolic health. Additionally, human growth hormone (HGH) stimulates IGF-1 production, contrasting with the direct muscle growth effects of IGF-1 LR3.
IGF-1 LR3 also enhances glucose uptake and stimulates various anabolic processes within muscle cells.
Research suggests that IGF-1 LR3 is known for its anabolic properties, promoting muscle protein synthesis and preventing muscle protein breakdown.
Furthermore, research suggests IGF-1 LR3 plays a significant role in promoting muscle tissues, aiding muscle repair, and enhancing growth through muscle hypertrophy.
Benefits of IGF-1 LR3 for Athletic Performance
Research suggests that IGF-1 LR3 offers a multitude of benefits for athletic performance, making it a popular choice among athletes and bodybuilders. Here are some of the key advantages:
Increased Muscle Mass: Research suggests IGF-1 LR3 promotes muscle hypertrophy by stimulating the proliferation and differentiation of satellite cells, leading to increased muscle mass. This makes it an excellent option for those looking to achieve significant muscle gains.
Enhanced Muscle Growth: By facilitating the development of lean muscle mass, research suggests IGF-1 LR3 helps athletes and bodybuilders achieve their muscle growth goals more efficiently.
Improved Muscle Repair: Research suggests IGF-1 LR3 accelerates recovery by enhancing protein synthesis, allowing for faster repair of damaged muscle tissue. This is particularly beneficial for those who engage in intense training sessions.
Reduced Risk of Overtraining: With its ability to promote faster recovery, research suggests IGF-1 LR3 reduces the risk of overtraining and related injuries, enabling athletes to maintain a consistent training regimen.
Increased Fat Loss: Research suggests IGF-1 LR3 contributes to fat loss, making it an appealing option for those looking to improve their body composition and reduce body fat.
Improved Insulin Sensitivity: Research suggests IGF-1 LR3 has been shown to improve insulin sensitivity, which can help reduce the risk of developing type 2 diabetes and support overall metabolic health.
These potential benefits make IGF-1 LR3 a powerful tool for enhancing athletic performance and achieving fitness goals.
Conclusion
In conclusion, IGF-1 LR3 stands out as a potent synthetic variant of the naturally occurring insulin-like growth factor, offering a range of benefits for muscle growth, repair, and athletic performance. Its longer half-life and enhanced bioavailability make it a valuable tool for those seeking increased muscle mass, improved recovery, and optimized metabolic health. However, it’s crucial to approach its use with caution and under the guidance of healthcare professionals to mitigate potential side effects and ensure safe usage. As research continues to explore its full potential, IGF-1 LR3 remains a significant focus in the realm of growth factors and performance enhancement.
[How to acquire IGF-1 LR3 with Longer Half Life](https://lotilabs.com/peptides/igf-1-lr3.html)
Insulin-like growth factor-1 LR3 can be acquired from labs. It undergoes top-notch quality control and is tested with high power liquid chromatography (HPLC) and mass spectrometry to ensure it is of the highest purity. IGF-1 LR3 is usually sold in lyophilized powder form as 1mg vials.
References
Tomas FM, Lemmey AB, Read LC, Ballard FJ (1996). “Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection”. J. Endocrinol. 150 (1): 77–84. doi:10.1677/joe.0.1500077. PMID 8708565.
Mohan S, Baylink DJ (2002). “IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms”. J. Endocrinol. 175 (1): 19–31. doi:10.1677/joe.0.1750019. PMID 12379487.
Tomas FM, Knowles SE, Owens PC, Chandler CS, Francis GL, Read LC, Ballard FJ (1992). “Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats”. Biochem. J. 282 ( Pt 1): 91–7. doi:10.1042/bj2820091. PMC 1130894. PMID 1371669.
Von der Thüsen JH, Borensztajn KS, Moimas S, van Heiningen S, Teeling P, van Berkel TJ, Biessen EA (2011). “IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype”. Am. J. Pathol. 178 (2): 924–34. doi:10.1016/j.ajpath.2010.10.007. PMC 3069834. PMID 21281823.
Mario Thevis (2010). Mass Spectrometry in Sports Drug Testing: Characterization of Prohibited Substances and Doping Control Analytical Assays. John Wiley & Sons. pp. 252–. ISBN 978-1-118-03514-6.
