CARDARINE (GW501516) Review | Buy Cardarine Liquid
Experimental studies of cardarine will open new possibilities in medicine. Additionally, research suggests that Cardarine may have positive effects on cardiovascular health by enhancing energy metabolism and endurance. Investigation of this research chemical demonstrates its potential to boost metabolism, increase fat burning, prevent obesity, and increase muscle growth in research studies. Loti Labs is your best choice to purchase the USA made cardarine if you are a scientist. It is strictly for research purposes and should NOT be used for human consumption.
In this review, we aim to consolidate existing clinical evidence of cardarine, highlighting its clinical prospects and challenges.
What is Cardarine (GW501516), How Does It Work, and Clinical Trials?
Cardarine is also known as GW501516, GW1516 or Endurobol, and is an aromatic ether that is phenoxy acetic acid. It is a synthetic Peroxisome Proliferator-Activated Receptor (PPAR) beta/delta Agonist. It is not a selective androgen receptor modulator (SARM), as previously thought in some circles, because it doesn’t act directly on androgen receptors.
PPARβ/δ is demonstrated in all tissues. It is abundant in the liver, intestine, kidney, abdominal adipose tissue, and skeletal muscle, all of which are involved in lipid and cholesterol metabolism. It takes part in fatty acid oxidation in skeletal and cardiac muscles, and regulating blood cholesterol concentrations, reducing adiposity and glucose levels, preventing obesity. In animal test subjects, PPARβ/δ is a regulator of fat consumption.
Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research and pharmaceutical discovery. Clinical implications of PPAR agonists span across a wide range of health conditions, including metabolic diseases, chronic inflammatory diseases, infections, autoimmune diseases, neurological and psychiatric disorders, and malignancies.
Cardarine reverses multiple abnormalities associated with the metabolic syndrome without increasing oxidative stress. This is consistent with PPARβ/δ being a potentially important target for providing cardiovascular protection in metabolic syndrome-like patients.
STRUCTURE OF CARDARINE and Cardiovascular Health
IUPAC Name: 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
Molecular Formula: C21H18 F3NO3S2
Molecular weight: 453.5 g/moll
CAS number: 317318-70-0
Understanding the Mechanism of Action of Cardarine (GW501516) and Peroxisome Proliferator Activated Receptor
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation.
Cardarine regulates glucose and lipid homeostasis. PPARβ/δ is expressed in most tissues in rodents such as the epithelia of the intestine, colon, and skin. It regulates fatty acid oxidation in these tissues increasing serum high-density lipoprotein cholesterol levels in insulin-resistant rats. It also decreases serum triglycerides, preventing high fat diet-induced obesity, increasing insulin sensitivity, and improving symptoms associated with metabolic syndrome through regulating the genes encoding fatty acid metabolizing enzymes in skeletal muscle, and the genes encoding lipogenic proteins in the liver.
Cardarine promotes terminal differentiation in keratinocytes, intestinal epithelium, oligodendrocytes, and osteoblasts, which is important for tumor development.
Research Context
Cardarine has garnered significant attention in the scientific community due to its potential benefits in various metabolic processes. As a potent agonist of the peroxisome proliferator-activated receptor delta (PPARδ), Cardarine plays a crucial role in regulating lipid metabolism, fatty acid oxidation, and glucose metabolism. These functions make it a valuable subject for laboratory research, particularly in understanding and potentially treating metabolic disorders.
Studies suggest that Cardarine can enhance energy metabolism, improve insulin resistance, and promote fat burning, making it a promising candidate for addressing conditions like obesity, diabetes, and cardiovascular diseases. Its ability to influence muscular endurance and physical endurance further underscores its potential applications in sports science and muscle building research. However, it is essential to note that Cardarine is strictly for research purposes and not for human consumption, as its long-term effects are still under investigation.
CARDARINE RESULTS: Fatty Acid Oxidation
Recently, studies in experimental animals demonstrated that cardarine plays a beneficial role in the treating of Metabolic syndrome, a disease characterized by multiple disorders, such as abdominal obesity, insulin resistance, hypertension, dyslipidemia, and atherosclerosis.
Glucose intolerance improves after treating with cardarine. The fasting blood glucose, and the serum high‐density lipoprotein cholesterol (HDL‐C) level is normalized. Postprandial blood glucose, serum insulin, leptin, free fatty acid (FFA) levels, and total cholesterol/HDL‐C ratio were also significantly decreased.
Semiquantitative reverse transcription-polymerase chain reaction results indicated that the above arrangements might be due to:
(i) Enhancement of fatty acid oxidation in muscle, adipose tissue, and the liver.
(ii) Improvement of insulin‐stimulated glucose transport in skeletal muscle, and adipose tissue.
(iii) Reduced local glucocorticoid synthesis.
Therefore, cardarine could significantly ameliorate dyslipidemia and insulin resistance in monosodium l‐glutamate mice, and activation of PPARδ could be envisioned as a useful strategy against human metabolic syndrome and related diseases such as diabetic cardiomyopathy.
Potential Side Effects
While Cardarine shows promise in various research applications, it is not without potential side effects. Some studies have raised concerns about its safety profile, particularly with prolonged use. Animal studies have indicated possible risks, including liver damage and an increased likelihood of developing certain cancers. These findings highlight the need for further research to fully understand the implications of Cardarine use.
In addition to these serious concerns, other potential side effects may include gastrointestinal discomfort, headaches, and changes in blood sugar levels. Given these risks, it is crucial for researchers to approach Cardarine studies with caution, ensuring that all experiments are conducted under strict ethical guidelines and regulatory oversight. The need for comprehensive clinical trials is evident to determine the safety and efficacy of Cardarine for any potential therapeutic use.
World Anti-Doping Agency (WADA) Status
The World Anti-Doping Agency (WADA) has classified Cardarine as a prohibited substance, reflecting its potential for misuse in sports. Athletes are banned from using Cardarine due to its performance-enhancing effects, which can provide an unfair advantage in terms of endurance and muscle building. This classification underscores the importance of drug test analysis in maintaining fair play in competitive sports.
WADA’s stance on Cardarine is based on its ability to significantly alter energy metabolism and improve physical performance, which can compromise the integrity of athletic competitions. As a result, athletes found using Cardarine face severe penalties, including disqualification and suspension. This prohibition also serves as a reminder of the ongoing need for vigilance and regulation in the use of performance-enhancing substances in sports.
LOOKING FOR WHERE TO BUY RESEARCH LIQUIDS
You can purchase cadarine from Loti Labs. It is important to buy research liquids which are USA-made, to ensure the integrity of your research. Cardarine is tested to ensure quality. It is available in liquid form and is commonly sold at a concentration of 10mg per ml.
Conclusion
In summary, Cardarine (GW501516) presents a promising avenue for research in metabolic regulation, cardiovascular health, and athletic performance. Its role as a potent agonist of the peroxisome proliferator-activated receptor delta (PPARδ) highlights its potential to enhance fatty acid oxidation, improve glucose metabolism, and promote overall energy balance. Although the compound shows great results in experimental settings, it is crucial to approach its study with caution due to potential side effects such as liver damage and cancer risks observed in animal studies. The World Anti-Doping Agency’s classification of Cardarine as a prohibited substance underscores the importance of responsible research and the need for further clinical trials to ensure its safety for any potential therapeutic use. As scientists continue to explore the depths of Cardarine’s capabilities, it remains a significant subject of interest for laboratory research, with the potential to impact future medical and sports science advancements.
References:
National Center for Biotechnology Information. PubChem Database. Endurobol, CID=9803963, https://pubchem.ncbi.nlm.nih.gov/compound/Endurobol (accessed on Dec. 8, 2019)
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Grygiel-Górniak B. Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications–a review. Nutr J. 2014;13:17. Published 2014 Feb 14. doi:10.1186/1475-2891-13-17
Marjorie A. Peraza, Andrew D. Burdick, Holly E. Marin, Frank J. Gonzalez, Jeffrey M. Peters, The Toxicology of Ligands for Peroxisome Proliferator-Activated Receptors (PPAR), Toxicological Sciences, Volume 90, Issue 2, April 2006, Pages 269–295, https://doi.org/10.1093/toxsci/kfj062
Oliver WR Jr, Shenk JL, Snaith MR, et al. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U S A. 2001;98(9):5306–5311. doi:10.1073/pnas.091021198
Dressel U, Allen TL, Pippal JB, Rohde PR, Lau P, Muscat GE. The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol Endocrinol. 2003;17(12):2477–2493. doi:10.1210/me.2003-0151
Chen W, Gao R, Xie X, et al. A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice. Sci Rep. 2015;5:9884. Published 2015 May 6. doi:10.1038/srep09884
