BPC-157 vs TB-500 | Buy BPC-157 & TB-500

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The role of peptides in many biological processes – whether by initiating a reaction, speeding processes up, stopping the action of catalytic enzymes, or stimulating the release of hormones – varies and highly dependent on their individual mechanisms of action.

Today, we will be comparing BPC-157 and TB-500, in terms of their chemistry, mechanism of action, and their effect.

Chemistry of BPC-157 and TB-500

Both BPC-157 and TB-500 are synthetic peptides in a sense that they are not found in nature and doesn’t share homology with natural peptides.

BPC-157 is a pentadecapeptide of BPC or Body Protection Compound that is found and isolated in the gastric juice of humans. It is a partial sequence of BPC and contains a chain of 15 amino acids.

TB-500, on the other hand, is also a synthetic form of Thymosin Beta 4 which is a water-soluble and regenerative compound found in tears, saliva, and cerebrospinal fluid. TB-500 is the isolated (17)LKKTETQ(23) segment of Thymosin Beta 4 which is the segment responsible for its effects.

Mechanism of Action

In terms of their mechanism of action, BPC-157 and TB-500 doesn’t differ that much. Both of their MOA are still poorly understood and researches are still underway to establish them.

Studies suggest that BPC-157 produces its effect by upregulating growth hormones, modulating Nitric Oxide synthesis, increase blood vessel production, and affect collagen production as well as bone proteins.

TB-500 mainly binds to actin, promote cellular migration and regeneration, and block inflammatory chemokines and cytokines.

Effects of BPC-157 and TB-500

Both peptides have demonstrated positive effects in several animal studies and in-vivo experiments.

BPC-157 The effect of BPC-157 generally revolves around its ability to increase angiogenesis or the production of blood vessels by affecting the expression of Vascular Endothelial Growth Factor 2 (VEGFR2). This increase in angiogenesis, sets off a cascade of different effects from faster wound healing, improved tendon and bone repair, and tissue regeneration in research subjects.

Another notable effect of BPC-157 is its ability to speed up tendon repair process and shorten the recovery time needed for damaged tendons to go back to its original strength.

BPC-157 also shows cytoprotective effect especially in the gastric mucosa, as well as the liver, pancreas, heart, and neurons of the brain. It currently being studied for its effect on treating Inflammatory Bowel Syndrome (IBS), anxiety, depression, Parkinson’s, and multiple sclerosis.

TB-500  The effects of TB-500, on the other hand, revolves around its ability to bind with actin and improve tissue regeneration and formation and wound healing. It also increases several factors such as cell migration, re-epithelialization, and angiogenesis that are important in tissue repair and wound healing.

TB-500 also exhibits anti-inflammatory effect by downregulating the release of chemokines and cytokines that are responsible for inflammation. It is currently being studied for its cardioprotective and neuroprotective potentials.

In-vitro and in-vivo tests in animals also show the ability of TB-500 to inhibit premature apoptosis or cell death in the heart and the hippocampal region of the brain.

Bottomline

In theory and based on the presented effects, both peptides are useful in wound healing and tissue formation. They both exhibit angiogenesis and cytoprotective effects, although they affect different factors in the process.

The difference is that BPC-157 has an effect on tendons and bone repair while TB-500 doesn’t. This means that it could potentially be more useful in injuries that involves tendons, ligaments, and bones. It also has more neurological effects compared to the latter.

TB-500 on the other hand has anti-inflammatory, cardioprotective, and neuroprotective effects that the other one lacks.