Ligandrol Sarm Review | Buy LGD-4033 Liquid
What is LGD-4033?
LGD-4033, also known as Ligandrol, is a selective androgen receptor modulator (SARM) that has garnered significant attention in the fitness and bodybuilding communities. Unlike anabolic steroids, which can affect multiple tissues indiscriminately, LGD-4033 is a nonsteroidal SARM that acts as an agonist of the androgen receptor (AR) with a high degree of selectivity. This means it can target specific tissues, such as muscle and bone, to exert its anabolic effects while minimizing unwanted side effects in other tissues like the prostate gland.
In preclinical studies, LGD-4033 has demonstrated a dissociation of effects between different tissues. It shows strong agonistic and anabolic effects in muscle and bone, promoting muscle growth and increasing bone mineral density. Conversely, it exhibits partially agonistic or even antagonistic effects in the prostate gland, which helps reduce the risk of prostate-related side effects commonly associated with traditional anabolic steroids like testosterone and dihydrotestosterone (DHT).
Ligandrol Sarm Review | Buy LGD-4033 Liquid for Muscle Wasting
LGD-4033 commonly also referred to as ligandrol is an investigational selective androgen receptor modulator (SARM) used in the treatment of muscle wasting, muscular dystrophy, osteoporosis and other similar conditions. Dosage recommendations for LGD-4033 often take into account an individual’s body weight to optimize its performance-enhancing effects. It was discovered by Ligand Pharmaceuticals based in San Diego and is currently being developed by Viking Therapeutics.
LGD-4033 and other SARMs compounds has been subjected to a lot of clinical research in the past two decades. LGD-4033 binds to androgen receptors with great affinity and precision, this simply means that it binds in a strong and targeted manner. Although LGD-4033 is compatible with most of the receptors, it isn’t compatible receptors found along the eyes and other areas with high androgen density.
Ligandrol is best known for the anabolic benefits it has on bones, muscles, and prostate glands.
Studies have revealed that LGD-4034 is expected to offer the same therapeutic benefits as testosterone but with improved tolerability and acceptance by patients, particularly in enhancing lean muscle mass.
Structure of LGD-4033: A Selective Androgen Receptor Modulator
Comprehensive Analysis of LGD-4033 Results and Benefits: Increased Muscle Mass
Studies on animal based subjects revealed the compound was well tolerated. There was no result of serious adverse effects related to the use of the compound. Frequency of adverse events was almost identical when compared in active and placebo groups. There was no significant change in hemoglobin, prostate-specific antigen, aspartate aminotransferase, alanine aminotransferase, or QT intervals at different concentrations of administration. Research indicated that the compound had a long elimination half-life and dose-proportional accumulation when multiple doses were administered to animal subjects. LGD-4033 administration was linked with changes such as; dose-dependent suppression of total testosterone, sex hormone–binding globulin, high density lipoprotein cholesterol, and triglyceride levels. Administration of little quantities of the compound caused a significant suppression of follicle-stimulating hormone and free testosterone. There was also a visible and significant increase in lean body mass, although fat mass did not change significantly. The compound has also been linked to increased muscle mass, making it a popular choice for those looking to enhance their physical performance. Hormone levels and lipids returned to baseline after administration of the compound was ceased.
There was conclusive evidence of the compound’s androgenic activity, as indicated by the increase in LBM, notable suppression of testosterone, sex hormone–binding globulin, and HDL cholesterol levels even when the compound was used over a short period. Despite the demonstrable androgenic activity, serum prostate-specific antigen was not significantly affected.
Ligandrol has numerous attractive PK features. Because of its long elimination half life, it can be administered once daily or even less frequently. Daily administration of the compound resulted in dose-proportional increases in systemic exposure which led to predictable accumulation upon multiple dosing.
As with all androgens, LGD-4033 was associated with significant suppression of HDL cholesterol. There was also a decrease in triglyceride levels, although LDL cholesterol was unaffected. In animal tests, the amount of anti-atherogenic effect of HDL cholesterol is influenced more by the mechanism of HDL modification than by the changes in HDL levels. In conclusion, the significance of the HDL decrease associated with oral androgens isn’t completely clear. Longer researches are required to shed more light on the cardiovascular risks associated with long-term SARM administration. For now, the first trials are likely to be centered on acute or subacute indications like cancer cachexia and functional limitations linked with acute illness or hip fracture, where the short-term changes in HDL cholesterol may not be of clinical use.
It is important to note that LGD-4033 is included on the World Anti-Doping Agency’s list of prohibited substances, highlighting its prevalence in sports and fitness circles as a performance-enhancing drug.
Clinical Research and Studies
Clinical research on LGD-4033 has shown promising results, particularly in its ability to improve lean body mass and muscle strength. Preliminary clinical trials have reported that LGD-4033 can dose-dependently enhance lean body mass, making it a potential candidate for treating conditions like muscle wasting and cachexia sarcopenia muscle. The drug is administered orally and has been found to have a long elimination half-life, which allows for convenient dosing schedules.
One of the standout features of LGD-4033 is its favorable pharmacokinetic profile. It is well tolerated by subjects and leads to predictable accumulation in the body upon multiple dosing. Even during short-term use, LGD-4033 has been shown to increase lean body mass without causing significant changes in prostate-specific antigen levels, which is a marker often monitored for prostate health.
Safety and Side Effects
While LGD-4033 is generally well tolerated, it is not without potential side effects. Some users have reported experiencing headaches, dry mouth, and adverse changes in lipid profiles, such as decreased HDL cholesterol levels. Additionally, changes in sex hormone concentrations, elevated liver enzymes, and liver toxicity have been observed in some cases.
One of the most commonly reported side effects of LGD-4033 is the suppression of natural testosterone production. This suppression can lead to a decrease in endogenous testosterone levels, which is why many users incorporate post-cycle therapy (PCT) after completing a cycle of LGD-4033. PCT helps restore natural testosterone levels and mitigate the hormonal imbalances caused by the SARM.
Dosage and Administration
The typical dosage of LGD-4033 ranges between 5-10 mg per day, taken orally. The duration of a cycle usually spans 8-12 weeks, with longer cycles generally not recommended due to the potential for significant suppression of natural testosterone production. It is crucial to follow a post-cycle therapy (PCT) protocol after completing a cycle of LGD-4033 to help restore natural testosterone levels and maintain the gains achieved during the cycle.
Legal Status and Availability
LGD-4033 is not approved for human consumption and is intended solely for research purposes. It is listed on the World Anti-Doping Agency’s list of prohibited substances, making it illegal for use in competitive sports. Despite this, LGD-4033 is often sold by black-market Internet suppliers for physique- and performance-enhancing purposes. However, many products sold online that claim to be LGD-4033 either contain none of the compound or contain other unrelated substances.
To ensure the purchase of genuine LGD-4033, it is essential to buy from reputable suppliers that provide detailed information about product purity and potency, backed by third-party lab testing. This ensures that the product meets the highest quality standards and is safe for research purposes.
Where to buy LGD-4033
LGD-4033 liquid for sale can be purchased from Loti Labs. Ligandrol purchased from Loti Labs meets the highest US quality standards by passing through testing by high power liquid chromatography (HPLC) and mass spectrometry. LGD-4033 is sold in a concentration of 10mg per ml.
REFERENCES
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Mazer NA. A novel spreadsheet method for calculating the free serum concentrations of testosterone, dihydrotestosterone, estradiol, estrone and cortisol: with illustrative examples from male and female populations. Steroids. 2009
Baumgartner RN, Waters DL, Gallagher D, Morley JE, Garry PJ. Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev. 1999
Orwoll E, Lambert LC, Marshall LM, et al. Endogenous testosterone levels, physical performance, and fall risk in older men. Arch Intern Med. 2006
