Tamoxifen Review | Buy Nolvadex Liquid
05December 5, 2019
Tamoxifen Review | Buy Nolvadex Liquid
Clinical research is significant and should be considered a priority in the health sector as its findings to introduce safe and effective medicine into the health system.
With further clinical evaluation, the most effective and safest medicine are discovered and authorized for healthy administration.
What is Tamoxifen Citrate?
The product was initially produced by chemist Dora Richardson in 1962. Tamoxifen also is known as Tamoxifen Citrate, or just TMX
Chemical and Physical Data of Tamoxifen
Tamoxifen is a nonsteroidal antiestrogen medication widely used in the treatment of breast cancer. Its chemical name is (Z)-2-[4-(1,2-diphenylbut-1-enyl)phenyl]-5-methyl-1,3-benzothiazol-3-ium, and it has a molecular formula of C26H29NO with a molecular weight of 371.51 g/mol. This compound appears as a white or off-white crystalline powder, which is soluble in ethanol and methanol. Tamoxifen is available in both tablet and oral solution forms, making it versatile for different treatment protocols.
Chemical and physical data Tamoxifen
Molecular formula: C2629NO
Molecular mass: 371.515 g/mol
563.638 g/mol (citrate salt) g.mol-1
Identifier
CAS number: 10540-29-1
Uses of Tamoxifen
Early Breast Cancer
Tamoxifen is one of the most effective compounds for the prevention of breast cancer and, it’s currently being investigated for other kinds of cancer. Tamoxifen has been evaluated in various clinical trials specifically targeted toward advanced breast cancer, detailing its efficacy compared to other therapies and its role in improving patient outcomes. For effective prevention of breast cancer, it typically takes five years of oral consumption or any other effective means such as the use of injection in animals for research purposes. Key clinical trials and meta-analyses have established tamoxifen’s role in reducing recurrence and mortality rates for early-stage breast cancer, setting a standard for treatment protocols. Tamoxifen’s significance in treating male breast cancer has also been emphasized, with its effectiveness validated through scientific methods.
Male Breast Cancer
Since its approval in 1998, the compound has been used for Albright Syndrome to treat premature puberty. It is popularly called McCune-Albright Syndrome (MAS). MAS is a disorder that affects the skin, bones, and endocrine or hormones-producing tissues.
Animal studies/research
Besides cancer and MAS treatments, Tamoxifen can be used for animal studies. It is administered into animals, the test subjects, as a research instrument to initiate tissue-specific gene expression in many conditional expression constructs of genetically modified animals.
Such administration into animals should be appropriately carried out in an LASC chemical housing room considering ABSL-2 type PPE (Personal Protective Equipment).
Administration of Tamoxifen in test subject (animals) can either be acute or chronic. Whatever the case may be, the use of an IP injection may be needed for a successful administration. The injection procedures for the administration should remain the same in both acute and chronic.
After successful administration, it is advisable for the test subject to be kept indoors in ABSL-2 for about three days.
Effects of Tamoxifen in Breast Cancer Prevention
Tamoxifen is one of the most used selective estrogen receptor modulator (SERM) or a partial agonist of the estrogen receptors (ER) and, it’s widely recommended for breast cancer and McCune-Albright Syndrome. Clinical studies focusing on tamoxifen treatment have shown its efficacy as an adjuvant therapy for early breast cancer, highlighting the benefits of extended treatment durations in reducing recurrence and mortality rates. There are several benefits that are derived from Tamoxifen.
Tamoxifen helps to:
Reduce the risk of breast cancer
Funk large hormone-receptor-positive before surgery
However, it will be a futile effort to use Tamoxifen for hormone-receptor-negative breast cancer as it only has used for hormone-receptor-positive breast cancer. As SERM, Tamoxifen has other benefits beyond using it for cancer and MAS treatment:
Regulate cholesterol levels
Stop the loss of bone (after menopause)
Prevent osteoporosis
Infertility treatment
Comprehensive Overview of Tamoxifen Uses in Metastatic Breast Cancer Treatment
The mechanism of action Tamoxifen or Tamoxifen/TMX is complex. It has been successful in rats. Furthermore, animal studies/research carried out using rats with the use of nitrosomethylurea and dimethylbenzanthracene (DMBA) as carcinogens revealed Tamoxifen was tremendously effective for the prevention of the development of experimental breast cancer.
The breast cancer index is a crucial tool in risk prediction programs that identify women at high risk of developing breast cancer. By considering factors such as mammographic density and genetic markers, these indices help tailor prevention strategies and screening approaches for breast cancer.
Tamoxifen in Breast Cancer Treatment
Tamoxifen is a cornerstone in the treatment of breast cancer for both men and women. It is highly effective in managing early-stage breast cancer and is also used to treat metastatic breast cancer, where the disease has spread to other parts of the body. As an adjuvant treatment, Tamoxifen significantly reduces the risk of breast cancer recurrence, providing a crucial line of defense post-surgery and radiation treatment. Often, it is used in combination with other treatments to enhance its efficacy and provide a comprehensive approach to battling breast cancer.
Tamoxifen for Breast Cancer Prevention
Tamoxifen plays a pivotal role in breast cancer prevention, particularly for women at high risk. It has been shown to reduce the risk of both invasive and non-invasive breast cancer. Additionally, for women who have already been diagnosed with breast cancer, Tamoxifen helps lower the risk of developing contralateral breast cancer. This preventive measure is often part of a broader strategy that includes regular mammograms and breast exams, ensuring a proactive approach to breast cancer risk reduction.
How Tamoxifen Works
Tamoxifen works by binding to estrogen receptors in breast cancer cells, effectively blocking the action of estrogen, which can promote the growth of these cells. This anti-estrogenic effect extends to other tissues, such as the uterus and bones, contributing to its overall therapeutic profile. However, this mechanism can also lead to side effects like hot flashes and other menopausal symptoms in some women. Tamoxifen is metabolized by the liver and excreted in the urine, ensuring that it is processed and eliminated efficiently from the body.
Where to buy Tamoxifen
Tamoxifen can be purchased in research form from Loti Labs. Tamoxifen generally is sold in liquid form in a concentration of 20mg per ml. Be sure that when purchasing tamoxifen you do so from a reputable online vendor that uses 3rd party testing on their products.
Reference
Tamoxifen Citrate. NCI. August 26, 2015. Archived from the original on 4 January 2016.Retrieved 28 November 2015.
Selective estrogen receptor modulators. Archived from the original on the 9 December 2013. I have retrieved 28 November 2015.
Jordan VC (January 2006). Tamoxifen (ICI46,474) as a therapy which was produced to treat and prevent breast cancer. British Journal of Pharmacology. 147 Suppl 1 (Suppl 1): S269-76.
Future Directions in Tamoxifen Research
The future of Tamoxifen research is promising, with ongoing studies exploring new ways to enhance its effectiveness in treating breast cancer. Researchers are investigating the potential of combining Tamoxifen with other medications to improve outcomes. Additionally, there is significant interest in using Tamoxifen for breast cancer prevention in high-risk women. Beyond breast cancer, studies are examining its efficacy in treating other cancers, such as ovarian and endometrial cancer. Innovative formulations, including topical creams and gels, are also being developed to provide more options for patients and potentially reduce side effects.
By following this structured approach, the new sections will provide a comprehensive and detailed overview of Tamoxifen, maintaining the informative and technical tone of the existing article.
