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In this article, we will be comparing GHRP-6 and GHRP-2 to help you make an informed decision on why you should choose to buy either hexapeptide despite their many similarities. These two growth hormone-releasing peptides have been discussed in the blogs GHRP-6 and GHRP-2.

A BRIEF INTRODUCTION OF GHRPs

Growth hormone-releasing peptides GHRPs are synthetic, non-natural peptides equipped with potent stimulatory effects on Growth hormone secretion in animal test subjects. They have no structural resemblance with Growth Hormone-Releasing Hormone and act through specific receptors present either at the pituitary or hypothalamic level in animals. The GH-releasing activity of GHRPs is noticeable and dose-related after intravenous subcutaneous intranasal and oral administration.

Though the way GHRPs work is still a blur, available data postulates that they could act by counteracting somatostatinergic activity both at the pituitary and hypothalamic level and partially through a GHRH-mediated mechanism.

GHRP-6 is the first hexapeptide to be extensively studied in mammals. Recently, GHRP-2 was synthesized and also available for animal studies.

The activity of Growth Hormone Releasing Peptides is lower than Growth Hormone Releasing Hormone. It is affected by glucose, free fatty acids, glucocorticoids, and exogenous somatostatin, which suppresses the effect of GHRH.

STRUCTURAL DIFFERENCES BETWEEN GHRP6 AND GHRP2

DIFFERENCES	GHRP 6	GHRP2
STRUCTURE
AMINO ACID SEQUENCE	His-D-Trp-Ala-Trp-D-Phe-Lys-NH2	D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
MOLECULAR FORMULA	C46H56N12O6	C45H55N9O6
MOLECULAR WEIGHT	873 g/mol	817.9 g/mo

 MECHANISM OF ACTION

The mechanism of action of GHRP-6 and GHRP-2 on GH release was investigated on experimental animals. Both peptides are associated with the classic effects of growth hormone receptor secretagogue receptor activation significantly increasing growth hormone and insulin-like growth factor 1 in experimental animals. GHRP-2 was found to stimulate GH release from rat pituitary cells via the same receptor, with a slight variation when compared to GHRP-6. GHRP-2 increases intracellular adenosine 3,5-monophosphate cAMP concentration like that of Growth Releasing Factor (GRF) while GHRP-6 causes a decrease in cAMP levels.

COMPARING AND CONTRASTING THE EFFECTS OF GHRP-6 AND GHRP-2

GHRP-6 and GHRP-2 have similar effects on animal test subjects but differ structurally. They both act on the pituitary gland to release growth hormone. The main difference is the amount of growth hormone released by both hexapeptides. The other differences are listed in the table below.

	GHRP-6	GHRP-2
Effect on hunger	Increases hunger markedly	Increases hunger slightly
Effect on growth hormone release	Less potent	More potent
Effect on prolactin and cortisol release	Less control	Has better control
Potency	less	more
Half-life	Longer half-life	Shorter half-life

CONCLUSION

Choosing whether to purchase GHRP-6 or GHRP-2 would depend on the effect you want to achieve; Whatever your choice is Loti Labs assures you of the highest quality USA-made peptides.

LOOKING FOR WHERE TO BUY PEPTIDES

GHRP-6 and GHRP-2 can be purchased from Loti Labs. It is important to buy USA-made peptides to ensure the integrity of your research. GHRP-6 and GHRP-2 sold from Loti Labs are tested through HPLC and Mass spectrometry to ensure quality. Both of the peptides are commonly sold in 5mg vials. It is available in lyophilized powder form. Buy your peptides from us today!

References

1. Camanni, Franco & Ghigo, Ezio & Arvat, Emanuela. (1998). Growth Hormone-Releasing Peptides and Their Analogs. Frontiers in neuroendocrinology. 19. 47-72. 10.1006/frne.1997.0158.

1. Wu D, Chen C, Zhang J, Bowers CY, Clarke IJ. The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3′,5′-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs. J Endocrinol. 1996;148(2):197–205. doi:10.1677/joe.0.1480197

1. Cheng J, Wu TJ, Butler B, Cheng K. Growth hormone-releasing peptides: a comparison of the growth hormone-releasing activities of GHRP-2 and GHRP-6 in rat primary pituitary cells. Life Sci. 1997;60(16):1385–1392. doi:10.1016/s0024-3205(96)00655-8