GHRP-2 Review | Buy GHRP-2 5mg
02December 2, 2019
GHRP-2 Review | Buy GHRP-2 5mg
GHRP-2 is another USA-made peptide available for sale at Loti Labs, a pioneer research company that stands for quality when it comes to peptide formulations. We recognize that a vast amount of study has been carried out on the functionality of GHRP-2 and would like to state once again that it is only intended for scientific study on animal test subjects. Chronic administration of GHRP-2 in animal studies has shown consistent stimulation of growth hormone release, although a partial attenuation of the response over time has been observed.
Understanding GHRP-2: Benefits, Mechanism, and Uses in Research as a Growth Hormone Releasing Peptide
Growth Hormone Releasing Peptide-2, also referred to as Pralmorelin or KP-102, is a new 2nd generation synthetic hexapeptide and synthetic agonist based on the fact that it is made up of 6 amino acids D-Alanyl-3-(2-naphthalenyl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide.
It is a potent member of the Growth Hormone Releasing Peptide family that is closely related to GHRP-6, a hexapeptide of an earlier generation, shares many similar characteristics but has a stronger growth hormone-releasing action than GHRP-6 based on a study on cultured pituitary cells which showed a 10-fold increase in GH secretion.
Ghrelin, the endogenous ligand for the growth hormone secretagogue receptor, plays a crucial role in regulating growth hormone release and influencing food intake and energy balance.
It is a peptide that is also an agonist of ghrelin, the newly found gut peptide. It is a pure human growth hormone secretagogue that acts on the hypothalamus and pituitary gland to secrete growth hormone in animal test subjects with a slight effect on prolactin, adrenocorticotropic hormone (ACTH) and cortisol levels.
GHRP-2 has been studied for its potential in treating GH deficiency, particularly in children with short stature, by enhancing linear growth.
Studies have shown that ghrelin levels, which GHRP-2 can influence, fluctuate based on energy balance, with increased levels in conditions like anorexia and decreased levels in obesity.
Studies on GHRP-2 are still ongoing and it isn’t yet recommended for human consumption.
Definition of GHRP-2 and its Relation to Growth Hormone Release
GHRP-2, also known as Growth Hormone Releasing Peptide-2, is a synthetic peptide designed to stimulate the release of growth hormone (GH) from the anterior pituitary gland. This potent peptide acts as an agonist of the growth hormone secretagogue receptor (GHS-R), the same receptor that the natural ligand ghrelin binds to. By engaging this receptor, GHRP-2 triggers a signaling cascade that culminates in the release of GH.
The increase in GH release induced by GHRP-2 can lead to several beneficial effects on the body. One of the primary outcomes is the elevated production of insulin-like growth factor-1 (IGF-1), a crucial mediator of growth hormone’s effects. Additionally, GHRP-2 can improve body composition by promoting muscle growth and reducing fat mass. These attributes make GHRP-2 a valuable tool for studying GH physiology and pathophysiology in both humans and animals.
Improved Sleep Quality and its Impact on Overall Health
Quality sleep is a cornerstone of overall health and well-being, and GHRP-2 has shown promise in enhancing sleep quality in both humans and animals. Although the exact mechanism remains under investigation, it is believed that GHRP-2 may help regulate the body’s natural sleep-wake cycle, or circadian rhythm, by increasing the release of growth hormone and other sleep-promoting hormones.
Enhanced sleep quality can yield numerous health benefits, including:
Enhanced Physical Recovery and Muscle Growth: Adequate sleep is essential for muscle repair and growth, making it crucial for athletes and individuals undergoing physical training.
Improved Mental Health and Mood: Quality sleep supports cognitive function and emotional stability, reducing the risk of mood disorders.
Increased Energy Levels and Reduced Fatigue: Better sleep translates to higher energy levels and less daytime fatigue, improving overall productivity and quality of life.
Better Glucose Regulation and Insulin Sensitivity: Proper sleep helps maintain healthy blood sugar levels and improves insulin sensitivity, reducing the risk of metabolic disorders.
Enhanced Immune Function: Quality sleep strengthens the immune system, helping the body fend off infections and illnesses.
Understanding the Molecular Structure of GHRP-2 Peptide
Sequence: D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
Molecular Formula: C45H55N9O6
Molecular weight: 817.9 g/mol
CAS number: 158861-67-7
MECHANISM OF ACTION: GH Secretion
Studies on animal test subjects suggest that GHRP-2 рlау а rоlе аѕ аn аgоnіѕt of ghrelin, thе rесеntlу-fоund gut рерtіdе. Ghrеlіn рерtіdе bіndѕ tо thе ѕесrеtаgоguе rесерtоr оf grоwth hоrmоnе (GН) аnd stimulates appetite аѕ wеll аѕ ѕtоmасh еmрtуіng.
However, it does more than this, it strongly stimulates the growth hormone secretion, with a slight simulator effect on Prolactin, ACTH and Cortisol levels, by a two-fold mechanism of action through improving the secretion of growth hormone-releasing hormone from the pituitary gland and reducing the impact of the hormone somatostatin (SRIF), which impairs the natural release of growth hormone. Consequently, GHRP-2 increases growth hormone levels and enhances growth performance in animal test subjects. The effects of GHRP-2 on GH responses have been observed in various species, with single and repeated administrations leading to increased GH levels and enhanced growth performance.
GHRP-2 EFFECTS on Insulin Like Growth Factor
It is a hexapeptide with strong attributes that tends to mimic that of endogenous growth hormone due to its ability to stimulate the production of ghrelin, otherwise known as the hunger hormone. Research has shown that GHRP-2 can influence body weight by affecting food intake and energy balance, with specific measurements provided per kilogram of body weight in animal studies. The theoretical benefits of GHRP-2 on animal test subjects show that it:
Decreases fat through lipolysis
Increases muscle mass
Speeds up wound healing
Promotes heart health
Decreases inflammation of the liver
Offers some form of pain relief
Improves lung injury
Improves sleep
Increases bone density
Improves immunity
Clinical Applications of GHRP-2 in Various Medical Fields
GHRP-2 holds potential for various clinical applications across multiple medical fields:
Growth Hormone Deficiency (GHD): GHRP-2 can be used as a diagnostic tool to assess GH release in patients suspected of having GHD. By stimulating GH release, it helps in evaluating the pituitary gland’s function.
Obesity and Metabolic Disorders: GHRP-2 may aid in improving body composition and glucose regulation in patients with obesity and metabolic disorders. Its ability to enhance GH release can lead to better fat metabolism and muscle growth.
Muscle Wasting Diseases: Conditions like muscular dystrophy, which involve muscle wasting, could benefit from GHRP-2’s muscle growth-promoting effects. It can help improve muscle mass and strength in affected patients.
Sleep Disorders: For patients suffering from sleep disorders such as insomnia, GHRP-2 may offer a solution by improving sleep quality and regulating the sleep-wake cycle.
Comparison with Other Peptides
Comparison of GHRP-2 with GHRP-6: Mechanisms and Benefits
GHRP-2 and GHRP-6 are both synthetic peptides that stimulate the release of growth hormone from the anterior pituitary gland, but they differ in their mechanisms and benefits.
GHRP-2 is a more potent agonist of the growth hormone secretagogue receptor (GHS-R) compared to GHRP-6. This means that GHRP-2 can stimulate GH release at lower doses, making it more efficient. Additionally, GHRP-2 has a faster onset of action, with peak GH levels reached within 15-30 minutes after administration.
On the other hand, GHRP-6 has a longer half-life, providing a more sustained increase in GH release over time. GHRP-6 also has a more pronounced effect on appetite and food intake, which can be beneficial for patients with muscle wasting diseases who need to increase their caloric intake.
Both peptides offer significant benefits, including improved body composition, increased muscle growth and strength, and enhanced sleep quality. However, GHRP-2 may be more effective for boosting GH release and IGF-1 production, while GHRP-6 may be better suited for increasing appetite and food intake.
Ultimately, the choice between GHRP-2 and GHRP-6 will depend on the individual patient’s needs and goals, with each peptide offering unique advantages based on its specific properties.
LOOKING FOR WHERE TO BUY PEPTIDES
GHRP-2 can be purchased from Loti Labs. It is important to buy peptides which are USA-made to ensure the integrity of your research. GHRP-2 sold from Loti Labs is tested through HPLC and Mass spectrometry to ensure quality. GHRP-2 is commonly sold in 5mg vials. It is available in lyophilized powder form.
References:
Argente J, García-Segura LM, Pozo J, Chowen JA. Growth hormone-releasing peptides: clinical and basic aspects. Horm Res. 1996;46(4-5):155–159. doi:10.1159/000185015
Ghigo E, Arvat E, Muccioli G, Camanni F. Growth hormone-releasing peptides. Eur J Endocrinol. 1997;136(5):445–460. doi:10.1530/eje.0.1360445
Peroni CN, Hayashida CY, Nascimento N, et al. Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient little mice. Clinics (Sao Paulo). 2012;67(3):265–272. doi:10.6061/clinics/2012(03)11
Liu C, Huang J, Li H, et al. Ghrelin accelerates wound healing through GHS-R1a-mediated MAPK-NF-κB/GR signaling pathways in combined radiation and burn injury in rats. Sci Rep. 2016;6:27499. Published 2016 Jun 7. doi:10.1038/srep27499
Hirotani, C., Oki, Y., Ukai, K. et al. Naunyn-Schmiedeberg’s Arch Pharmacol (2005) 371: 54. https://doi.org/10.1007/s00210-004-1009-3
