CJC-1295 w/DAC Review | Buy CJC-1295 Peptide
27NovNovember 27, 2019
CJC-1295 is a synthetic peptide that has gained popularity for its potential to increase growth hormone levels. It is a long-acting analog of GH-releasing hormone, which stimulates the secretion of growth hormone and insulin-like growth factor I. Clinical trials have shown that CJC-1295 can sustain these effects over a prolonged period, making it a promising option for enhancing growth hormone levels in healthy adults.
What is CJC-1295?
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) designed to stimulate growth hormone (GH) production in the human body. This 30-amino acid peptide mimics the natural pulses of GH released by the pituitary gland, leading to an increase in both GH and insulin-like growth factor-1 (IGF-1) levels. By enhancing these natural processes, CJC-1295 supports various physiological functions, including muscle growth and fat metabolism. Often, CJC-1295 is combined with Ipamorelin, a growth hormone-releasing peptide (GHRP), to amplify its effects, making it a popular choice in peptide therapy for those looking to optimize their growth hormone levels.
How CJC-1295 Works
CJC-1295 operates by binding to the growth hormone-releasing hormone (GHRH) receptor on the anterior pituitary gland. This interaction stimulates the release of growth hormone (GH), which then prompts the liver to produce insulin-like growth factor-1 (IGF-1). The increase in GH and IGF-1 levels promotes muscle growth, fat loss, and other anabolic effects beneficial to the human body. One of the standout features of CJC-1295 is its prolonged half-life, achieved through the addition of a drug affinity complex (DAC). This modification allows for less frequent dosing while ensuring a steady increase in GH and IGF-1 levels, providing prolonged stimulation and consistent benefits over time.
CJC-1295 w/Drug Affinity Complex Review | Buy CJC-1295 Peptide
What is CJC-1295 with DAC?
CJC 1295 with DAC
CJC-1295 is a synthetically modified and tetrasubstituted form of Growth Hormone-Releasing Hormone (GHRH1-29). The substitution of four amino acids from the core moiety makes CJC-1295 peptide more resistant to cleaving by proteolytic enzymes.
It contains a chain of 30 amino acids, a molecular weight of 3368.7, and molecular formula of C152H252N44O42 . CJC-1295 works by binding to serum albumin a, the addition of Drug Affinity Complex or DAC prolongs the half-life of CJC-1295 as well as the duration of action in animal test subjects.
Mechanism of Action of CJC-1295 with DAC
Studies of CJC-1295 peptide using animal test subjects and research studies in the field of growth horm igf res show how this peptide works by interacting with the Growth Hormone (GH), Insulin-like Growth Factor 1 (IGF-1), and Dipeptidyl Amino Peptidase-IV (DPP-IV) enzyme.
DPP-IV is an antigenic enzyme involved for things such as signal transduction, apoptosis or programmed cell death, and immune system regulation. It has also a direct effect on the half-life of Growth Hormone (GH) cutting it to just under seven minutes.
CJC-1295 has shown to reduce the production of the DPP-IV enzyme. This results in a feedback loop where the half-life GH and IGF-1 is prolonged and last more than seven days after administration on animal test subjects.
CJC-1295 Effects
The mechanism of action of CJC-1295 peptide shows how it can dramatically increase Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1)’s half-life which in turn elevates the processes which involves GH and IGF-1. Below are some of these effects:
Increased Protein Synthesis. The prolonged half-life of GH and IGF-1 caused by CJC-1295 has been found to increase the rate of protein synthesis in animal subjects. This results to a significant growth in their muscle size and muscle mass over time.
Increased Bone Density. The increase in protein synthesis has been found to have a role in boosting bone density. Animal subjects has shown to have higher mineral matter per square centimeter in their bones after they are given CJC-1295.
Decreased Body Fat. The effect of CJC-1295 on DPP-IV and GHRH has also been found to play an important role in lipolysis or the reduction of body fat. It has been found to increase lipolysis in test subjects thus reducing their total body fat.
Improves Quality of Sleep. Although there is no way to quantitatively measure the quality of sleep animal subjects gets, this effect is based on the reasoning that the elevated rate of protein synthesis is compensated by elevated amount of deep sleep as well.
CJC-1295 without DAC vs CJC-1295 with DAC
When buying peptides, it is important to know the effects of these peptides and how the addition of certain compounds can alter its properties. The market offers a variety of options for those who are looking to buy peptides.
Although unmodified CJC-1295 has shown to exhibit the effects discussed above, the addition of DAC is said to improve its overall effect. Animal tests also shows that CJC-1295 with DAC has higher protein synthesis effects, faster recovery time, higher increase in bone density, and higher muscle growth effects compared to that with the unmodified CJC-1295. Peptides like Sermorelin and Modified GRF 1-29 have a very short half-life, producing rapid pulses of growth hormone, which is viewed as a more natural approach compared to CJC-1295 + DAC, which has a significantly longer half-life. (Reference 1)
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References:
Benquet C, Castaigne J-P, Pham K, Robitaille M, Frohman LA, CJC-1295 (DAC-GRF), a long acting GRF analog, enhances pulsatile GH secretion, increases IGF-I levels, and restores linear growth. Program of the 86th Annual Meeting of The Endocrine Society, New Orleans, LA, 2004, p 491 (Abstract P3-109)
